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Strada Gene Detail
Summary
  • Symbol
    Strada
  • Name
    STE20-related kinase adaptor alpha
  • Synonyms
    2610019A05Rik, 6030402H20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919399
    NCBI Gene: 72149
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:106053739-106084460 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 68.89 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    631 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919399
 protein coding gene Chr11:106053739-106092994 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019296
 protein coding gene Chr11:109443236-109484766 (-)
A/J MGP_AJ_G0019264
 protein coding gene Chr11:104788200-104829473 (-)
AKR/J MGP_AKRJ_G0019233
 protein coding gene Chr11:107914777-107953900 (-)
BALB/cJ MGP_BALBcJ_G0019238
 protein coding gene Chr11:105190204-105229216 (-)
C3H/HeJ MGP_C3HHeJ_G0019047
 protein coding gene Chr11:108202298-108244357 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019688
 protein coding gene Chr11:112795985-112840808 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017312
 protein coding gene Chr11:102065624-102108046 (-)
CAST/EiJ MGP_CASTEiJ_G0018600
 protein coding gene Chr11:109260632-109299571 (-)
CBA/J MGP_CBAJ_G0019016
 protein coding gene Chr11:117492943-117536432 (-)
DBA/2J MGP_DBA2J_G0019128
 protein coding gene Chr11:104257689-104297058 (-)
FVB/NJ MGP_FVBNJ_G0019119
 protein coding gene Chr11:103758563-103798739 (-)
LP/J MGP_LPJ_G0019198
 protein coding gene Chr11:109890517-109930012 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019149
 protein coding gene Chr11:116780221-116820860 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019725
 protein coding gene Chr11:108402734-108446552 (-)
PWK/PhJ MGP_PWKPhJ_G0018365
 protein coding gene Chr11:105352531-105392790 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018156
 protein coding gene Chr11:108167458-108210132 (-)
WSB/EiJ MGP_WSBEiJ_G0018651
 protein coding gene Chr11:108366437-108409461 (-)



Homology
more
  • Human Ortholog
    STRADA, STE20 related adaptor alpha
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STRADA, STE20 related adaptor alpha
  • Synonyms
    LYK5, NY-BR-96, PMSE, Stlk, STRAD, STRAD alpha
  • Links
    NCBI Gene ID: 92335
    neXtProt AC: NX_Q7RTN6
    UniProt: Q7RTN6

  • Chr Location
    17q23.3; chr17:63682336-63741986 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human STRADA associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit incomplete postnatal lethality, decreased body size, domed skulls, malocclusion of incisors, hypotonia, tremors, enlarged brain ventricles, and abnormal neuron migration with ectopic neurons.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    715
  • Tissues
    5
  • cDNA Data
    60
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 72149 NCBI Gene Model | MGI Sequence Detail 30722 C57BL/6J ±  kb
    transcript NM_001252448 RefSeq | MGI Sequence Detail 2578 C57BL/6  
    polypeptide Q3UUJ4 UniProt | EBI | MGI Sequence Detail 431 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000015774 STE20-related kinase adapter protein alpha
      (term hierarchy)
    • InterPro Domains
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR047173 STE20-related kinase adapter protein alpha/beta-like
    • GlyGen
      Q3UUJ4 2 sites, 2 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 61
      cDNA 61

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:2144190, MGI:2443040
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 4
      Gene Ontology 8
      Phenotypes 12
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory