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Tram1 Gene Detail
Summary
  • Symbol
    Tram1
  • Name
    translocating chain-associating membrane protein 1
  • Synonyms
    1810049E02Rik, MGC:1174, TRAMP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919515
    NCBI Gene: 72265
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:13634922-13660134 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 4.18 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    788 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919515
 protein coding gene Chr1:13634917-13660134 (-)
129S1/SvImJ MGP_129S1SvImJ_G0015842
 protein coding gene Chr1:10925825-10958289 (-)
A/J MGP_AJ_G0015824
 protein coding gene Chr1:10882561-10908436 (-)
AKR/J MGP_AKRJ_G0015783
 protein coding gene Chr1:10816867-10842103 (-)
BALB/cJ MGP_BALBcJ_G0015780
 protein coding gene Chr1:10590679-10615914 (-)
C3H/HeJ MGP_C3HHeJ_G0015614
 protein coding gene Chr1:10788033-10817253 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016234
 protein coding gene Chr1:11459828-11486465 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0013955
 protein coding gene Chr1:9506121-9534080 (-)
CAST/EiJ MGP_CASTEiJ_G0015194
 protein coding gene Chr1:10990269-11017426 (-)
CBA/J MGP_CBAJ_G0015587
 protein coding gene Chr1:11695676-11723942 (-)
DBA/2J MGP_DBA2J_G0015686
 protein coding gene Chr1:10501740-10527111 (-)
FVB/NJ MGP_FVBNJ_G0015691
 protein coding gene Chr1:10311792-10337535 (-)
LP/J MGP_LPJ_G0015758
 protein coding gene Chr1:11119670-11152628 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015710
 protein coding gene Chr1:12423237-12448617 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016281
 protein coding gene Chr1:10727578-10757910 (-)
PWK/PhJ MGP_PWKPhJ_G0014978
 protein coding gene Chr1:10310884-10336969 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014759
 protein coding gene Chr1:10953553-10983435 (-)
WSB/EiJ MGP_WSBEiJ_G0015258
 protein coding gene Chr1:10738015-10769262 (-)



Homology
more
  • Human Ortholog
    TRAM1, translocation associated membrane protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRAM1, translocation associated membrane protein 1
  • Synonyms
    PNAS8, TRAM, TRAMP
  • Links
    NCBI Gene ID: 23471
    neXtProt AC: NX_Q15629
    UniProt: Q15629

  • Chr Location
    8q13.3; chr8:70573218-70608416 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    5
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    226
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025935 Ensembl Gene Model | MGI Sequence Detail 25213 C57BL/6J ±  kb
    transcript ENSMUST00000027068 Ensembl | MGI Sequence Detail 2938 Not Applicable  
    polypeptide ENSMUSP00000027068 Ensembl | MGI Sequence Detail 374 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000001745 translocation-associated membrane protein 1
      (term hierarchy)
    • InterPro Domains
      IPR006634 TRAM/LAG1/CLN8 homology domain
      IPR016447 Translocation associated membrane protein
    • GlyGen
      Q91V04 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 226
      cDNA 226

      Microarray probesets 5
    References
    more
    • Summaries
      All 33
      Gene Ontology 5
      Phenotypes 7
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory