Lsm11 MGI Mouse Gene Detail - MGI:1919540 - U7 snRNP-specific Sm-like protein LSM11

Symbol

Lsm11
Name

U7 snRNP-specific Sm-like protein LSM11
Synonyms

2210404M20Rik

Feature Type

protein coding gene
IDs

MGI:1919540
NCBI Gene: 72290
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr11:45819096-45835762 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 27.46 cM
Mapping Data

2 experiments

SNPs within 2kb

733 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919540	protein coding gene	Chr11:45819096-45835762 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018185	protein coding gene	Chr11:44812682-44829346 (-)
A/J	MGP_AJ_G0018157	protein coding gene	Chr11:43095312-43111976 (-)
AKR/J	MGP_AKRJ_G0018121	protein coding gene	Chr11:44336452-44353120 (-)
BALB/cJ	MGP_BALBcJ_G0018126	protein coding gene	Chr11:43260518-43277182 (-)
C3H/HeJ	MGP_C3HHeJ_G0017940	protein coding gene	Chr11:44383403-44400067 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018580	protein coding gene	Chr11:46155352-46172018 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016235	protein coding gene	Chr11:41094065-41108731 (-)
CAST/EiJ	MGP_CASTEiJ_G0017503	protein coding gene	Chr11:44456623-44504270 (-)
CBA/J	MGP_CBAJ_G0017912	protein coding gene	Chr11:48309157-48325821 (-)
DBA/2J	MGP_DBA2J_G0018022	protein coding gene	Chr11:42848160-42864826 (-)
FVB/NJ	MGP_FVBNJ_G0018016	protein coding gene	Chr11:42527280-42543943 (-)
LP/J	MGP_LPJ_G0018094	protein coding gene	Chr11:45062245-45078994 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018040	protein coding gene	Chr11:49857981-49874649 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018619	protein coding gene	Chr11:44505000-44521670 (-)
PWK/PhJ	MGP_PWKPhJ_G0017283	protein coding gene	Chr11:42924434-42940854 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017076	protein coding gene	Chr11:44286816-44303786 (-)
WSB/EiJ	MGP_WSBEiJ_G0017553	protein coding gene	Chr11:44198706-44214613 (-)

Human Ortholog

LSM11, LSM11, U7 small nuclear RNA associated

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LSM11, LSM11, U7 small nuclear RNA associated
Synonyms

AGS8
Links

HGNC:30860

NCBI Gene ID: 134353

neXtProt AC: NX_P83369

UniProt: P83369
Chr Location

5q33.3; chr5:157743712-157760709 (+) GRCh38

MGI Vertebrate Homology

Lsm11 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LSM11
Gene Tree

Lsm11

Diseases

1 with human LSM11 associations

				Human Disease	Mouse Models
				Aicardi-Goutieres syndrome IDs Aicardi-Goutieres syndrome DOID:0050629 ICD10CM:G31.8 OMIM:225750 OMIM:610181 OMIM:610329 OMIM:610333 OMIM:612952 OMIM:615010 OMIM:615846 OMIM:PS225750 ORDO:51

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

2
Genomic Mutations

1 involving Lsm11
Incidental Mutations

APF
Find Mice (IMSR)

18 strains or lines available

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All GO Annotations

26
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

755
Tissues

5
cDNA Data

52
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lsm11

ZFIN lsm11

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All Sequences

42
RefSeq

2
UniProt

3
CCDS

CCDS36131.1

Ensembl

ENSMUSG00000044847 (Evidence)
NCBI Gene

72290

			Length	Strain/Species	Flank
genomic	72290	NCBI Gene Model \| MGI Sequence Detail	16667	C57BL/6J	± kb
transcript	NM_028185	RefSeq \| MGI Sequence Detail	6453	C57BL/6
polypeptide	Q8BUV6	UniProt \| EBI \| MGI Sequence Detail	361	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000009956 U7 snRNA-associated Sm-like protein LSm11

(term hierarchy)
InterPro Domains

IPR010920 LSM domain superfamily

IPR047575 Sm domain

IPR001163 Sm domain, eukaryotic/archaea-type

IPR034109 Sm-like protein Lsm11, middle domain

IPR039267 U7 snRNA-associated Sm-like protein Lsm11

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All nucleic 53

Genomic 1

cDNA 52

Microarray probesets 5

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MGI:2144458

Summaries

All 37

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 8
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Lsm11:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr107577	Chr11:45835737-45835787 (-)	0 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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