Tmem158 Gene Detail

Summary

• Symbol
  Tmem158
• Name
  transmembrane protein 158
• Synonyms
  2310037P21Rik, Ris1

• Feature Type
  protein coding gene
• IDs
  MGI:1919559
  NCBI Gene: 72309
• Alliance
  gene page
• Transcription Start Sites
  3 TSS

Location &
Maps

• Sequence Map
  Chr9:123088118-123089829 bp, - strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 9, 73.92 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  124 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919559	protein coding gene	Chr9:123088118-123089854 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0035475	protein coding gene	Chr9:126288599-126290330 (-)
A/J	MGP_AJ_G0035456	protein coding gene	Chr9:121459904-121461635 (-)
AKR/J	MGP_AKRJ_G0035389	protein coding gene	Chr9:124718475-124720206 (-)
BALB/cJ	MGP_BALBcJ_G0035452	protein coding gene	Chr9:121384004-121385735 (-)
C3H/HeJ	MGP_C3HHeJ_G0035159	protein coding gene	Chr9:125164025-125165756 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0035975	protein coding gene	Chr9:129783216-129784947 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032857	protein coding gene	Chr9:118590619-118592344 (-)
CAST/EiJ	MGP_CASTEiJ_G0034464	protein coding gene	Chr9:125196752-125198481 (-)
CBA/J	MGP_CBAJ_G0035127	protein coding gene	Chr9:134492630-134494361 (-)
DBA/2J	MGP_DBA2J_G0035286	protein coding gene	Chr9:120909793-120911524 (-)
FVB/NJ	MGP_FVBNJ_G0035233	protein coding gene	Chr9:119814307-119816038 (-)
LP/J	MGP_LPJ_G0035365	protein coding gene	Chr9:126627136-126628867 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035274	protein coding gene	Chr9:135336568-135338299 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035994	protein coding gene	Chr9:125178585-125180316 (-)
PWK/PhJ	MGP_PWKPhJ_G0034168	protein coding gene	Chr9:121357755-121359484 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0034005	protein coding gene	Chr9:125279112-125280845 (-)
WSB/EiJ	MGP_WSBEiJ_G0034584	protein coding gene	Chr9:125020352-125022084 (-)

Homology

• Human Ortholog
  TMEM158, transmembrane protein 158

• Vertebrate Orthologs
  2

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  TMEM158, transmembrane protein 158
  
• Synonyms
  BBP, p40BBP, RIS1
• Links
  HGNC:30293

  NCBI Gene ID: 25907

  neXtProt AC: NX_Q8WZ71

  UniProt: Q8WZ71

  
  
• Chr Location
  3p21.31; chr3:45224466-45226287 (-)  GRCh38

---

• MGI Vertebrate Homology
  Tmem158 stringent orthology
  1 human;1 mouse;1 rat
  
• HCOP
  vertebrate homology predictions: TMEM158
• Gene Tree
  Tmem158
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  6 phenotype references
  

• All Mutations and Alleles
  6
• Endonuclease-mediated
  3
• Targeted
  3
• Incidental Mutations
  CvDC
• Find Mice (IMSR)
  14 strains or lines available

Mice homozygous for a knock-out allele are viable, fertile and developmentally normal, and exhibit a normal lifespan and no predisposition to spontaneous or chemically-induced tumors.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  4
• GO References
  4

Expression

• Assay Results
  736
• Tissues
  22
• cDNA Data
  21
• Literature Summary
  1

Images

Tissue x Stage Matrix

• Other Mouse Links
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  36
• RefSeq
  2
• UniProt
  2
• CCDS
  CCDS23658.1

• Ensembl
  ENSMUSG00000054871 (Evidence)
• NCBI Gene
  72309

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000054871	Ensembl Gene Model | MGI Sequence Detail	1712	C57BL/6J
transcript	ENSMUST00000068140	Ensembl | MGI Sequence Detail	1712	Not Applicable
polypeptide	ENSMUSP00000069161	Ensembl | MGI Sequence Detail	286	Not Applicable

Protein
Information

• UniProt
  2 Sequences
• Protein Ontology
  PR:000016415 transmembrane protein 158
  (term hierarchy)
• InterPro Domains
  IPR038962 Transmembrane protein 158
• GlyGen
  Q6F5E0 1 site, 3 N-linked glycans (1 site)

Molecular
Reagents

• All nucleic 23

  cDNA 21

  Primer pair 1

  Other 1

  
  

  Microarray probesets 6

References

• Summaries
  All 26

  Developmental Gene Expression 1

  Gene Ontology 4

  Phenotypes 6
• Earliest
  J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
• Latest
  J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Tmem158:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr92136	Chr9:123089879-123089887 (-)	-54 bp
Tssr92135	Chr9:123089841-123089868 (-)	-26 bp
Tssr92134	Chr9:123089821-123089838 (-)	-1 bp