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Fryl Gene Detail
Summary
  • Symbol
    Fryl
  • Name
    FRY like transcription coactivator
  • Synonyms
    2310004H21Rik, 2510002A14Rik, 9030227G01Rik, mKIAA0826
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919563
    NCBI Gene: 72313
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:73177534-73414042 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 38.44 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6931 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919563
 protein coding gene Chr5:73177330-73414042 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029622
 protein coding gene Chr5:73000751-73247562 (-)
A/J MGP_AJ_G0029590
 protein coding gene Chr5:70268764-70506247 (-)
AKR/J MGP_AKRJ_G0029538
 protein coding gene Chr5:72543731-72786936 (-)
BALB/cJ MGP_BALBcJ_G0029599
 protein coding gene Chr5:70976893-71224611 (-)
C3H/HeJ MGP_C3HHeJ_G0029322
 protein coding gene Chr5:72906801-73191307 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030053
 protein coding gene Chr5:75987513-76260571 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027293
 protein coding gene Chr5:65968315-66201952 (-)
CAST/EiJ MGP_CASTEiJ_G0028730
 protein coding gene Chr5:71978635-72250123 (-)
CBA/J MGP_CBAJ_G0029289
 protein coding gene Chr5:78435908-78745993 (-)
DBA/2J MGP_DBA2J_G0029436
 protein coding gene Chr5:70319965-70585643 (-)
FVB/NJ MGP_FVBNJ_G0029397
 protein coding gene Chr5:69485162-69722187 (-)
LP/J MGP_LPJ_G0029522
 protein coding gene Chr5:73435054-73685691 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029424
 protein coding gene Chr5:81786720-82043782 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030086
 protein coding gene Chr5:72092168-72335335 (-)
PWK/PhJ MGP_PWKPhJ_G0028453
 protein coding gene Chr5:69286877-69551305 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028288
 protein coding gene Chr5:71443634-71684803 (-)
WSB/EiJ MGP_WSBEiJ_G0028810
 protein coding gene Chr5:72370224-72626147 (-)



Homology
more
  • Human Ortholog
    FRYL, FRY like transcription coactivator
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FRYL, FRY like transcription coactivator
  • Synonyms
    AF4p12, KIAA0826, MOR2
  • Links
    NCBI Gene ID: 285527
    neXtProt AC: NX_O94915
    UniProt: O94915

  • Chr Location
    4p11; chr4:48497357-48780322 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 3 alleles in 3 genetic backgrounds
    376 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Most mice homozygous for a knock-out allele exhibit postnatal lethality and defects in kidney development; rare survivors display growth retardation, decreased body weight, and premature death associated with chronic hydronephrosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    746
  • Tissues
    11
  • cDNA Data
    144
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 72313 NCBI Gene Model | MGI Sequence Detail 236509 C57BL/6J ±  kb
    transcript NM_028194 RefSeq | MGI Sequence Detail 11488 C57BL/6  
    polypeptide NP_082470 RefSeq | MGI Sequence Detail 3007 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      15 Sequences
    • InterPro Domains
      IPR016024 Armadillo-type fold
      IPR029473 Cell morphogenesis central region
      IPR025481 Cell morphogenesis protein C-terminal
      IPR025614 Cell morphogenesis protein N-terminal
      IPR045842 Protein furry, C-terminal
      IPR039867 Protein furry/Tao3/Mor2
    • GlyGen
      F8VQ05 2 sites, 2 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 145
      cDNA 145

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1914271, MGI:1922825, MGI:2141007, MGI:2443838
    References
    more
    • Summaries
      All 402
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 2
      Phenotypes 376
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:358639 Su Y, et al., Brainstem Dbh(+) neurons control allergen-induced airway hyperreactivity. Nature. 2024 Jul;631(8021):601-609
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory