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Kifbp Gene Detail
Summary
  • Symbol
    Kifbp
  • Name
    kinesin family binding protein
  • Synonyms
    0710007C18Rik, 2510003E04Rik, Kif1bp, mKIAA1279
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919570
    NCBI Gene: 72320
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:62394249-62414846 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 32.43 cM, cytoband B4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    654 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919570
 protein coding gene Chr10:62374405-62414846 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017301
 protein coding gene Chr10:61971025-62019442 (-)
A/J MGP_AJ_G0017279
 protein coding gene Chr10:60077631-60116821 (-)
AKR/J MGP_AKRJ_G0017239
 protein coding gene Chr10:61642623-61684048 (-)
BALB/cJ MGP_BALBcJ_G0017239
 protein coding gene Chr10:60160573-60199957 (-)
C3H/HeJ MGP_C3HHeJ_G0017062
 protein coding gene Chr10:61562400-61605155 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017697
 protein coding gene Chr10:64190824-64233088 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015387
 protein coding gene Chr10:57042955-57086302 (-)
CAST/EiJ MGP_CASTEiJ_G0016633
 protein coding gene Chr10:61613601-61661550 (-)
CBA/J MGP_CBAJ_G0017034
 protein coding gene Chr10:66603388-66648319 (-)
DBA/2J MGP_DBA2J_G0017139
 protein coding gene Chr10:59349173-59389127 (-)
FVB/NJ MGP_FVBNJ_G0017133
 protein coding gene Chr10:58620807-58661150 (-)
LP/J MGP_LPJ_G0017213
 protein coding gene Chr10:62359909-62402565 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017161
 protein coding gene Chr10:68822984-68866317 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017735
 protein coding gene Chr10:61479794-61528602 (-)
PWK/PhJ MGP_PWKPhJ_G0016416
 protein coding gene Chr10:59220110-59266739 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016198
 protein coding gene Chr10:60853690-60895215 (-)
WSB/EiJ MGP_WSBEiJ_G0016697
 protein coding gene Chr10:61418658-61463745 (-)



Homology
more
  • Human Ortholog
    KIFBP, kinesin family binding protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KIFBP, kinesin family binding protein
  • Synonyms
    KBP, KIAA1279, KIF1BP, TTC20
  • Links
    NCBI Gene ID: 26128
    neXtProt AC: NX_Q96EK5
    UniProt: Q96EK5

  • Chr Location
    10q22.1; chr10:68988803-69043544 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Kifbp mouse models; 1 with human KIFBP associations

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    40 phenotypes from 3 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous KO mice die shortly after birth from respiratory failure. Knockout affects innervation of the digestive tract, and the development of the olfactory bulb and the anterior commissure in the brain.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    731
  • Tissues
    18
  • cDNA Data
    13
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 72320 NCBI Gene Model | MGI Sequence Detail 20598 C57BL/6J ±  kb
    transcript NM_028197 RefSeq | MGI Sequence Detail 2535 C57BL/6  
    polypeptide Q6ZPU9 UniProt | EBI | MGI Sequence Detail 617 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 13
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1915665, MGI:6368823
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 7
      Phenotypes 18
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:350444 Martinez-Mayer J, et al., Knockout mice with pituitary malformations help identify human cases of hypopituitarism. Genome Med. 2024 May 31;16(1):75
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory