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Palld Gene Detail
Summary
  • Symbol
    Palld
  • Name
    palladin, cytoskeletal associated protein
  • Synonyms
    2410003B16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919583
    NCBI Gene: 72333
  • Alliance
    gene page
  • Transcription Start Sites
    28 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:61964467-62355724 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 31.23 cM, cytoband B3.3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    10409 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919583
 protein coding gene Chr8:61964465-62355741 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033636
 protein coding gene Chr8:61436197-61848746 (-)
A/J MGP_AJ_G0033618
 protein coding gene Chr8:58816971-59213435 (-)
AKR/J MGP_AKRJ_G0033543
 protein coding gene Chr8:60509526-60924161 (-)
BALB/cJ MGP_BALBcJ_G0033614
 protein coding gene Chr8:59069362-59462078 (-)
C3H/HeJ MGP_C3HHeJ_G0033324
 protein coding gene Chr8:61177369-61585261 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034131
 protein coding gene Chr8:63771125-64178320 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031079
 protein coding gene Chr8:54063757-54446694 (-)
CAST/EiJ MGP_CASTEiJ_G0032649
 protein coding gene Chr8:60594678-60996365 (-)
CBA/J MGP_CBAJ_G0033302
 protein coding gene Chr8:66083703-66534736 (-)
DBA/2J MGP_DBA2J_G0033456
 protein coding gene Chr8:58569715-58961068 (-)
FVB/NJ MGP_FVBNJ_G0033397
 protein coding gene Chr8:57873890-58266653 (-)
LP/J MGP_LPJ_G0033544
 protein coding gene Chr8:61408838-61818070 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033441
 protein coding gene Chr8:68183571-68603535 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034149
 protein coding gene Chr8:60764025-61175218 (-)
PWK/PhJ MGP_PWKPhJ_G0032358
 protein coding gene Chr8:57878148-58270516 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032194
 protein coding gene Chr8:59730079-60125065 (-)
WSB/EiJ MGP_WSBEiJ_G0032766
 protein coding gene Chr8:61093352-61496750 (-)



Homology
more
  • Human Ortholog
    PALLD, palladin, cytoskeletal associated protein
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PALLD, palladin, cytoskeletal associated protein
  • Synonyms
    CGI-151, CGI151, MYN, PNCA1, SIH002
  • Links
    NCBI Gene ID: 23022
    neXtProt AC: NX_Q8WX93
    UniProt: Q8WX93

  • Chr Location
    4q32.3; chr4:168497052-168928457 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PALLD associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
All homozygous null embryos die around E15.5 displaying exencephaly derived from neural tube closure defects, and herniation of the intestine and liver due to ventral closure defects. Mutant MEFs show impaired formation of actin stress fibers, reduced migration and decreased adhesion to fibronectin.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    990
  • Tissues
    67
  • cDNA Data
    15
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000058056 Ensembl Gene Model | MGI Sequence Detail 391258 C57BL/6J ±  kb
    transcript ENSMUST00000121785 Ensembl | MGI Sequence Detail 6349 Not Applicable  
    polypeptide ENSMUSP00000112442 Ensembl | MGI Sequence Detail 1408 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      cDNA 21
      Primer pair 10
      Other 1

      Microarray probesets 8
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 10
      Gene Ontology 11
      Phenotypes 15
    • Earliest
      J:282685 Parast MM, et al., Characterization of palladin, a novel protein localized to stress fibers and cell adhesions. J Cell Biol. 2000 Aug 7;150(3):643-56
    • Latest
      J:350307 Mastrototaro G, et al., Ablation of palladin in adult heart causes dilated cardiomyopathy associated with intercalated disc abnormalities. Elife. 2023 Mar 16;12
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory