Aif1l MGI Mouse Gene Detail - MGI:1919598 - allograft inflammatory factor 1-like

Symbol

Aif1l
Name

allograft inflammatory factor 1-like
Synonyms

2810003C17Rik

Feature Type

protein coding gene
IDs

MGI:1919598
NCBI Gene: 108897
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr2:31840315-31863454 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 21.95 cM
Mapping Data

2 experiments

SNPs within 2kb

571 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919598	protein coding gene	Chr2:31840151-31863454 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025593	protein coding gene	Chr2:30344722-30372135 (+)
A/J	MGP_AJ_G0025571	protein coding gene	Chr2:29086333-29109618 (+)
AKR/J	MGP_AKRJ_G0025540	protein coding gene	Chr2:30083753-30106454 (+)
BALB/cJ	MGP_BALBcJ_G0025567	protein coding gene	Chr2:29210184-29233744 (+)
C3H/HeJ	MGP_C3HHeJ_G0025328	protein coding gene	Chr2:30005231-30028305 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026012	protein coding gene	Chr2:31294802-31315794 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023420	protein coding gene	Chr2:27824340-27847717 (+)
CAST/EiJ	MGP_CASTEiJ_G0024790	protein coding gene	Chr2:29946615-29969876 (+)
CBA/J	MGP_CBAJ_G0025305	protein coding gene	Chr2:32446900-32479204 (+)
DBA/2J	MGP_DBA2J_G0025438	protein coding gene	Chr2:28856742-28879992 (+)
FVB/NJ	MGP_FVBNJ_G0025401	protein coding gene	Chr2:28708736-28735318 (+)
LP/J	MGP_LPJ_G0025524	protein coding gene	Chr2:30235681-30258884 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025431	protein coding gene	Chr2:32153005-32177580 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026070	protein coding gene	Chr2:30002525-30025759 (+)
PWK/PhJ	MGP_PWKPhJ_G0024537	protein coding gene	Chr2:28748700-28772437 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024337	protein coding gene	Chr2:30141733-30169333 (+)
WSB/EiJ	MGP_WSBEiJ_G0024858	protein coding gene	Chr2:30175968-30200436 (+)

Human Ortholog

AIF1L, allograft inflammatory factor 1 like

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AIF1L, allograft inflammatory factor 1 like
Synonyms

C9orf58, IBA2
Links

HGNC:28904

NCBI Gene ID: 83543

neXtProt AC: NX_Q9BQI0

UniProt: Q9BQI0
Chr Location

9q34.12-q34.13; chr9:131096476-131123152 (+) GRCh38

MGI Vertebrate Homology

Aif1l stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: AIF1L
Gene Tree

Aif1l

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

2
Gene trapped

2
Targeted

4
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

17
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

774
Tissues

20
cDNA Data

10
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA C9ORF58

Xenbase aif1l

ZFIN aif1l

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All Sequences

50
RefSeq

2
UniProt

3
CCDS

CCDS15904.1

Ensembl

ENSMUSG00000001864 (Evidence)
NCBI Gene

108897

			Length	Strain/Species	Flank
genomic	108897	NCBI Gene Model \| MGI Sequence Detail	23140	C57BL/6J	± kb
transcript	NM_145144	RefSeq \| MGI Sequence Detail	2967	FVB/N
polypeptide	Q9EQX4	UniProt \| EBI \| MGI Sequence Detail	150	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000003867 allograft inflammatory factor 1-like

(term hierarchy)
InterPro Domains

IPR042433 Allograft inflammatory factor 1

IPR049025 Allograft inflammatory factor 1-like, EF-hand domain pair

IPR002048 EF-hand domain

IPR011992 EF-hand domain pair

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All nucleic 10

cDNA 10

Microarray probesets 7

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MGI:2138829, MGI:2139534

Summaries

All 45

Developmental Gene Expression 5

Gene Ontology 8

Phenotypes 13
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Aif1l:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr17219	Chr2:31840269-31840293 (+)	-34 bp
Tssr17220	Chr2:31840302-31840313 (+)	-7 bp
Tssr17221	Chr2:31840319-31840327 (+)	8 bp
Tssr17222	Chr2:31840340-31840350 (+)	30 bp
Tssr17223	Chr2:31852026-31852036 (+)	11,716 bp
Tssr17224	Chr2:31852074-31852084 (+)	11,764 bp
Tssr17225	Chr2:31852192-31852209 (+)	11,886 bp
Tssr17226	Chr2:31852213-31852254 (+)	11,919 bp
Tssr459	Chr2:31855694-31855697 (+)	15,381 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24