Psca MGI Mouse Gene Detail - MGI:1919623 - prostate stem cell antigen

Symbol

Psca
Name

prostate stem cell antigen
Synonyms

2210408B04Rik

Feature Type

protein coding gene
IDs

MGI:1919623
NCBI Gene: 72373
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr15:74586688-74588914 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 34.26 cM
Mapping Data

2 experiments

SNPs within 2kb

195 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919623	protein coding gene	Chr15:74586688-74588918 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021931	protein coding gene	Chr15:74497302-74499522 (+)
A/J	MGP_AJ_G0021890	protein coding gene	Chr15:71838730-71840960 (+)
AKR/J	MGP_AKRJ_G0021872	protein coding gene	Chr15:73679307-73681537 (+)
BALB/cJ	MGP_BALBcJ_G0021897	protein coding gene	Chr15:71846050-71848280 (+)
C3H/HeJ	MGP_C3HHeJ_G0021670	protein coding gene	Chr15:73832356-73834586 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022337	protein coding gene	Chr15:77311178-77313408 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019873	protein coding gene	Chr15:68250744-68253072 (+)
CAST/EiJ	MGP_CASTEiJ_G0021189	protein coding gene	Chr15:74653479-74655709 (+)
CBA/J	MGP_CBAJ_G0021636	protein coding gene	Chr15:79847067-79849297 (+)
DBA/2J	MGP_DBA2J_G0021761	protein coding gene	Chr15:71437032-71439262 (+)
FVB/NJ	MGP_FVBNJ_G0021743	protein coding gene	Chr15:70479765-70481995 (+)
LP/J	MGP_LPJ_G0021833	protein coding gene	Chr15:74556625-74558855 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021766	protein coding gene	Chr15:85162779-85165009 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022358	protein coding gene	Chr15:74067181-74069411 (+)
PWK/PhJ	MGP_PWKPhJ_G0020930	protein coding gene	Chr15:71542753-71544973 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020771	protein coding gene	Chr15:73956252-73958485 (+)
WSB/EiJ	MGP_WSBEiJ_G0021241	protein coding gene	Chr15:74077478-74079708 (+)

Human Ortholog

PSCA, prostate stem cell antigen

Vertebrate Orthologs

1

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PSCA, prostate stem cell antigen
Synonyms

lncPSCA, PRO232
Links

HGNC:9500

NCBI Gene ID: 8000

neXtProt AC: NX_O43653

UniProt: O43653
Chr Location

8q24.3; chr8:142670297-142682725 (+) GRCh38

MGI Vertebrate Homology

Psca stringent orthology
1 human;1 mouse
HCOP

vertebrate homology predictions: PSCA
Gene Tree

Psca

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References

1 with disease annotations

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
3 phenotypes from multigenic genotypes
32 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

3
Endonuclease-mediated

4
Radiation induced

2
Targeted

4
Genomic Mutations

5 involving Psca
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygous null mice are viable and fertile and show no significant differences in spontaneous or radiation-induced primary epithelial tumor formation relative to wild-type littermates.

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All GO Annotations

13
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

740
Tissues

24
cDNA Data

16
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

29
RefSeq

2
UniProt

1
CCDS

CCDS27526.1

Ensembl

ENSMUSG00000022598 (Evidence)
NCBI Gene

72373

			Length	Strain/Species	Flank
genomic	72373	NCBI Gene Model \| MGI Sequence Detail	2227	C57BL/6J	± kb
transcript	NM_028216	RefSeq \| MGI Sequence Detail	876	C57BL/6
polypeptide	P57096	UniProt \| EBI \| MGI Sequence Detail	123	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000013340 prostate stem cell antigen

(term hierarchy)
InterPro Domains

IPR018363 CD59 antigen, conserved site

IPR016054 Ly-6 antigen/uPA receptor-like

IPR051110 Ly-6/neurotoxin-like and GPI-anchored

IPR045860 Snake toxin-like superfamily
GlyGen

P57096 1 site

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All nucleic 18

cDNA 16

Primer pair 2

Microarray probesets 2

Summaries

All 58

Developmental Gene Expression 3

Diseases 1

Gene Ontology 6

Phenotypes 32
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Psca:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr131573	Chr15:74586681-74586697 (+)	1 bp
Tssr131574	Chr15:74587863-74587881 (+)	1,184 bp
Tssr131575	Chr15:74587883-74587893 (+)	1,200 bp
Tssr131576	Chr15:74588310-74588320 (+)	1,627 bp
Tssr131577	Chr15:74588363-74588366 (+)	1,677 bp
Tssr131578	Chr15:74588451-74588457 (+)	1,766 bp
Tssr131579	Chr15:74588479-74588509 (+)	1,806 bp
Tssr131580	Chr15:74588515-74588525 (+)	1,832 bp
Tssr131581	Chr15:74588554-74588568 (+)	1,873 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24