Kcnmb2 MGI Mouse Gene Detail - MGI:1919663 - potassium large conductance calcium-activated channel, subfamily M, beta member 2

Symbol

Kcnmb2
Name

potassium large conductance calcium-activated channel, subfamily M, beta member 2
Synonyms

2700049B16Rik, 3110031N04Rik, MGC:57945

Feature Type

protein coding gene
IDs

MGI:1919663
NCBI Gene: 72413
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr3:31956656-32254329 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 15.48 cM
Mapping Data

2 experiments

SNPs within 2kb

9079 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919663	protein coding gene	Chr3:31956021-32254329 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027134	protein coding gene	Chr3:29471549-29776118 (+)
A/J	MGP_AJ_G0027094	protein coding gene	Chr3:29090597-29403718 (+)
AKR/J	MGP_AKRJ_G0027063	protein coding gene	Chr3:29542291-29848933 (+)
BALB/cJ	MGP_BALBcJ_G0027106	protein coding gene	Chr3:28742000-29038353 (+)
C3H/HeJ	MGP_C3HHeJ_G0026849	protein coding gene	Chr3:29549227-29854435 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027552	protein coding gene	Chr3:30997964-31298275 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024913	protein coding gene	Chr3:26955895-27235913 (+)
CAST/EiJ	MGP_CASTEiJ_G0026302	protein coding gene	Chr3:29397345-29718063 (+)
CBA/J	MGP_CBAJ_G0026826	protein coding gene	Chr3:31807365-32111473 (+)
DBA/2J	MGP_DBA2J_G0026960	protein coding gene	Chr3:28569226-28858576 (+)
FVB/NJ	MGP_FVBNJ_G0026928	protein coding gene	Chr3:28041770-28336683 (+)
LP/J	MGP_LPJ_G0027072	protein coding gene	Chr3:30237161-30557954 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026948	protein coding gene	Chr3:34336684-34646510 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027611	protein coding gene	Chr3:29301837-29604819 (+)
PWK/PhJ	MGP_PWKPhJ_G0026035	protein coding gene	Chr3:28110099-28400944 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025847	protein coding gene	Chr3:28746906-29035749 (+)
WSB/EiJ	MGP_WSBEiJ_G0026376	protein coding gene	Chr3:29342850-29633243 (+)

Human Ortholog

KCNMB2, potassium calcium-activated channel subfamily M regulatory beta subunit 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KCNMB2, potassium calcium-activated channel subfamily M regulatory beta subunit 2
Links

HGNC:6286

NCBI Gene ID: 10242

neXtProt AC: NX_Q9Y691

UniProt: Q9Y691
Chr Location

3q26.32; chr3:178272932-178844429 (+) GRCh38

MGI Vertebrate Homology

Kcnmb2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: KCNMB2
Gene Tree

Kcnmb2

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References

1 with disease annotations

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Endonuclease-mediated

1
Gene trapped

7
Radiation induced

1
Targeted

4
Genomic Mutations

1 involving Kcnmb2
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

17 strains or lines available

Homozygous inactivation of this gene abolishes inactivation of BK currents in mouse adrenal chromaffin cells and results in slow-wave burst activity.

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All GO Annotations

17
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

2
cDNA Data

8
Literature Summary

2

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase kcnmb2

ZFIN kcnmb2a

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All Sequences

56
RefSeq

14
UniProt

4
CCDS

CCDS17292.1

Ensembl

ENSMUSG00000037610 (Evidence)
NCBI Gene

72413

			Length	Strain/Species	Flank
genomic	ENSMUSG00000037610	Ensembl Gene Model \| MGI Sequence Detail	297674	C57BL/6J	± kb
transcript	ENSMUST00000192429	Ensembl \| MGI Sequence Detail	2357	Not Applicable
polypeptide	ENSMUSP00000141656	Ensembl \| MGI Sequence Detail	235	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000009267 calcium-activated potassium channel subunit beta-2

(term hierarchy)
InterPro Domains

IPR015382 KCNMB2, ball/chain domain

IPR037096 KCNMB2, ball/chain domain superfamily

IPR003930 Potassium channel, calcium-activated, BK, beta subunit
GlyGen

Q9CZM9 3 sites

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All nucleic 9

cDNA 8

Primer pair 1

Microarray probesets 3

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MGI:1920369

Summaries

All 33

Developmental Gene Expression 2

Diseases 1

Gene Ontology 5

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:305429 Kaiser M, et al., Regulation of otocyst patterning by Tbx2 and Tbx3 is required for inner ear morphogenesis in the mouse. Development. 2021 Apr 15;148(8):dev195651

TSS for Kcnmb2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr28733	Chr3:31956797-31956808 (+)	147 bp
Tssr28734	Chr3:31956815-31956829 (+)	166 bp
Tssr28738	Chr3:32038361-32038379 (+)	81,714 bp
Tssr28739	Chr3:32121425-32121458 (+)	164,786 bp
Tssr28740	Chr3:32128244-32128250 (+)	171,591 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24