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Lypd3 Gene Detail
Summary
  • Symbol
    Lypd3
  • Name
    Ly6/Plaur domain containing 3
  • Synonyms
    2310061G07Rik, C4.4A
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919684
    NCBI Gene: 72434
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:24335995-24340543 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 11.95 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    205 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919684
 protein coding gene Chr7:24335975-24340543 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031838
 protein coding gene Chr7:22972806-22977348 (+)
A/J MGP_AJ_G0031817
 protein coding gene Chr7:22436347-22440911 (+)
AKR/J MGP_AKRJ_G0031746
 protein coding gene Chr7:22938186-22942740 (+)
BALB/cJ MGP_BALBcJ_G0031823
 protein coding gene Chr7:22655307-22659807 (+)
C3H/HeJ MGP_C3HHeJ_G0031543
 protein coding gene Chr7:23359049-23363585 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032286
 protein coding gene Chr7:23726820-23731322 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029344
 protein coding gene Chr7:23906369-23910852 (+)
CAST/EiJ MGP_CASTEiJ_G0030884
 protein coding gene Chr7:16859713-16865054 (+)
CBA/J MGP_CBAJ_G0031508
 protein coding gene Chr7:24617235-24624353 (+)
DBA/2J MGP_DBA2J_G0031662
 protein coding gene Chr7:22351038-22355588 (+)
FVB/NJ MGP_FVBNJ_G0031615
 protein coding gene Chr7:22319556-22324108 (+)
LP/J MGP_LPJ_G0031741
 protein coding gene Chr7:23334049-23338716 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031652
 protein coding gene Chr7:24384106-24388577 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032318
 protein coding gene Chr7:22677115-22681755 (+)
PWK/PhJ MGP_PWKPhJ_G0030608
 protein coding gene Chr7:17245893-17250483 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030438
 protein coding gene Chr7:13989835-13994339 (+)
WSB/EiJ MGP_WSBEiJ_G0030987
 protein coding gene Chr7:22793844-22798342 (+)



Homology
more
  • Human Ortholog
    LYPD3, LY6/PLAUR domain containing 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LYPD3, LY6/PLAUR domain containing 3
  • Synonyms
    C4.4A
  • Links
    NCBI Gene ID: 27076
    neXtProt AC: NX_O95274
    UniProt: O95274

  • Chr Location
    19q13.31; chr19:43460787-43465608 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show no overt epidermal phenotype and have normal squamous epithelia morphology but are lighter and leaner than controls. Males display delayed wound healing whereas females show reduced food intake and a lower incidence of invasive lesions in a BBN-induced bladder cancer model.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    903
  • Tissues
    124
  • cDNA Data
    18
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 72434 NCBI Gene Model | MGI Sequence Detail 4549 C57BL/6J ±  kb
    transcript NM_133743 RefSeq | MGI Sequence Detail 1659 FVB/N  
    polypeptide Q91YK8 UniProt | EBI | MGI Sequence Detail 363 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 18

      Microarray probesets 3
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory