Tbcd MGI Mouse Gene Detail - MGI:1919686 - tubulin-specific chaperone d

Symbol

Tbcd
Name

tubulin-specific chaperone d
Synonyms

2310057L06Rik, A030005L14Rik, mKIAA0988

Feature Type

protein coding gene
IDs

MGI:1919686
NCBI Gene: 108903
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr11:121342817-121507996 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 85.41 cM, cytoband E2
Mapping Data

2 experiments

SNPs within 2kb

3366 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919686	protein coding gene	Chr11:121342775-121507996 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019550	protein coding gene	Chr11:126000219-126169924 (+)
A/J	MGP_AJ_G0019517	protein coding gene	Chr11:120358546-120522114 (+)
AKR/J	MGP_AKRJ_G0019487	protein coding gene	Chr11:124012418-124184578 (+)
BALB/cJ	MGP_BALBcJ_G0019492	protein coding gene	Chr11:120738183-120904262 (+)
C3H/HeJ	MGP_C3HHeJ_G0019298	protein coding gene	Chr11:124327188-124514902 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019941	protein coding gene	Chr11:129815303-129992653 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017566	protein coding gene	Chr11:117347902-117511076 (+)
CAST/EiJ	MGP_CASTEiJ_G0018852	protein coding gene	Chr11:125831233-126000355 (+)
CBA/J	MGP_CBAJ_G0019269	protein coding gene	Chr11:134830328-135033702 (+)
DBA/2J	MGP_DBA2J_G0019382	protein coding gene	Chr11:119746668-119913512 (+)
FVB/NJ	MGP_FVBNJ_G0019373	protein coding gene	Chr11:119450908-119637983 (+)
LP/J	MGP_LPJ_G0019453	protein coding gene	Chr11:126274232-126447530 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019406	protein coding gene	Chr11:133655497-133829688 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019980	protein coding gene	Chr11:124703417-124877022 (+)
PWK/PhJ	MGP_PWKPhJ_G0018619	protein coding gene	Chr11:121177027-121344463 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018410	protein coding gene	Chr11:124447121-124621862 (+)
WSB/EiJ	MGP_WSBEiJ_G0018905	protein coding gene	Chr11:124665715-124835428 (+)

Human Ortholog

TBCD, tubulin folding cofactor D

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TBCD, tubulin folding cofactor D
Synonyms

PEBAT, SSD-1, tfcD
Links

HGNC:11581

NCBI Gene ID: 6904

neXtProt AC: NX_Q9BTW9

UniProt: Q9BTW9
Chr Location

17q25.3; chr17:82752042-82945914 (+) GRCh38

MGI Vertebrate Homology

Tbcd stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TBCD
Gene Tree

Tbcd

Diseases

1 with human TBCD associations

				Human Disease	Mouse Models
				early onset progressive encephalopathy with brain atrophy and thin corpus callosum IDs early onset progressive encephalopathy with brain atrophy and thin corpus callosum DOID:0070423 OMIM:617193 ORDO:496641

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

2 phenotypes from 1 allele in 2 genetic backgrounds
1 images
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Endonuclease-mediated

2
Gene trapped

15
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

66 strains or lines available

Mice homozygous for a knock-out allele exhibit complete embryonic lethality between implantation and somite formation.

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All GO Annotations

35
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

11

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tbcd

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All Sequences

74
RefSeq

10
UniProt

5
CCDS

CCDS25778.1

Ensembl

ENSMUSG00000039230 (Evidence)
NCBI Gene

108903

			Length	Strain/Species	Flank
genomic	108903	NCBI Gene Model \| MGI Sequence Detail	165180	C57BL/6J	± kb
transcript	NM_029878	RefSeq \| MGI Sequence Detail	3870	C57BL/6
polypeptide	Q8BYA0	UniProt \| EBI \| MGI Sequence Detail	1196	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000016128 tubulin-specific chaperone D

(term hierarchy)
InterPro Domains

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR033162 Tubulin-folding cofactor D

IPR022577 Tubulin-specific chaperone D, C-terminal

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All nucleic 11

cDNA 11

Microarray probesets 3

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MGI:1924463

Summaries

All 35

Gene Ontology 5

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tbcd:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr106405	Chr11:121342780-121342796 (+)	-29 bp
Tssr106406	Chr11:121342799-121342862 (+)	14 bp
Tssr106407	Chr11:121378789-121378830 (+)	35,993 bp
Tssr106408	Chr11:121410246-121410262 (+)	67,437 bp
Tssr106409	Chr11:121435023-121435047 (+)	92,218 bp
Tssr106410	Chr11:121440671-121440682 (+)	97,860 bp
Tssr106411	Chr11:121447045-121447049 (+)	104,230 bp
Tssr106412	Chr11:121450575-121450587 (+)	107,764 bp
Tssr106413	Chr11:121483390-121483398 (+)	140,577 bp
Tssr106414	Chr11:121483419-121483439 (+)	140,612 bp
Tssr106415	Chr11:121492519-121492536 (+)	149,711 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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