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Prcp Gene Detail
Summary
  • Symbol
    Prcp
  • Name
    prolylcarboxypeptidase (angiotensinase C)
  • Synonyms
    2510048K03Rik, 2610104A14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919711
    NCBI Gene: 72461
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:92524461-92583789 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 51.64 cM, cytoband E2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1833 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919711
 protein coding gene Chr7:92523678-92583791 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032516
 protein coding gene Chr7:95438186-95496206 (+)
A/J MGP_AJ_G0032490
 protein coding gene Chr7:93054400-93108491 (+)
AKR/J MGP_AKRJ_G0032426
 protein coding gene Chr7:95273585-95340343 (+)
BALB/cJ MGP_BALBcJ_G0032501
 protein coding gene Chr7:92722302-92776841 (+)
C3H/HeJ MGP_C3HHeJ_G0032216
 protein coding gene Chr7:95645881-95708069 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032999
 protein coding gene Chr7:99117712-99191679 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029994
 protein coding gene Chr7:95835919-95886252 (+)
CAST/EiJ MGP_CASTEiJ_G0031543
 protein coding gene Chr7:87133033-87193571 (+)
CBA/J MGP_CBAJ_G0032183
 protein coding gene Chr7:102472704-102534593 (+)
DBA/2J MGP_DBA2J_G0032335
 protein coding gene Chr7:91485000-91546485 (+)
FVB/NJ MGP_FVBNJ_G0032291
 protein coding gene Chr7:91322877-91377677 (+)
LP/J MGP_LPJ_G0032424
 protein coding gene Chr7:96691375-96756247 (+)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0033021
 protein coding gene Chr7:94594340-94662484 (+)
PWK/PhJ MGP_PWKPhJ_G0031261
 protein coding gene Chr7:84554890-84609626 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031104
 protein coding gene Chr7:81897983-81954664 (+)
WSB/EiJ MGP_WSBEiJ_G0031660
 protein coding gene Chr7:95243323-95302235 (+)



Homology
more
  • Human Ortholog
    PRCP, prolylcarboxypeptidase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRCP, prolylcarboxypeptidase
  • Synonyms
    HUMPCP, PCP
  • Links
    NCBI Gene ID: 5547
    neXtProt AC: NX_P42785
    UniProt: P42785

  • Chr Location
    11q14.1; chr11:82822936-82970584 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit decreased body length, weight, and fat pads with resistance to diet-induced obesity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    931
  • Tissues
    15
  • cDNA Data
    58
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 72461 NCBI Gene Model | MGI Sequence Detail 59329 C57BL/6J ±  kb
    transcript NM_028243 RefSeq | MGI Sequence Detail 2964 C57BL/6  
    polypeptide Q7TMR0 UniProt | EBI | MGI Sequence Detail 491 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 58
      cDNA 58

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1917679, MGI:2141970
    References
    more
    • Summaries
      All 77
      Developmental Gene Expression 3
      Gene Ontology 11
      Phenotypes 45
    • Earliest
      J:141526 Russell LB, et al., Analysis of the albino-locus region of the mouse. III. Time of death of prenatal lethals. Genetics. 1979 May;92(1):205-13
    • Latest
      J:338426 Nguyen BY, et al., Prolylcarboxypeptidase Alleviates Hypertensive Cardiac Remodeling by Regulating Myocardial Tissue Angiotensin II. J Am Heart Assoc. 2023 Jun 20;12(12):e028298
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory