Slc16a10 MGI Mouse Gene Detail - MGI:1919722 - solute carrier family 16 (monocarboxylic acid transporters), member 10

Symbol

Slc16a10
Name

solute carrier family 16 (monocarboxylic acid transporters), member 10
Synonyms

2610103N14Rik, Mct10, PRO0813, TAT1

Feature Type

protein coding gene
IDs

MGI:1919722
NCBI Gene: 72472
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr10:39909528-40018254 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 21.48 cM, cytoband B1
Mapping Data

3 experiments

SNPs within 2kb

2643 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919722	protein coding gene	Chr10:39909528-40018262 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017159	protein coding gene	Chr10:38577298-38683533 (-)
A/J	MGP_AJ_G0017136	protein coding gene	Chr10:37538196-37644784 (-)
AKR/J	MGP_AKRJ_G0017096	protein coding gene	Chr10:38071330-38179768 (-)
BALB/cJ	MGP_BALBcJ_G0017099	protein coding gene	Chr10:37608895-37717535 (-)
C3H/HeJ	MGP_C3HHeJ_G0016919	protein coding gene	Chr10:38393507-38502942 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017557	protein coding gene	Chr10:39761550-39876747 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015253	protein coding gene	Chr10:35518101-35619271 (-)
CAST/EiJ	MGP_CASTEiJ_G0016498	protein coding gene	Chr10:38571547-38677252 (-)
CBA/J	MGP_CBAJ_G0016893	protein coding gene	Chr10:41588403-41705715 (-)
DBA/2J	MGP_DBA2J_G0016998	protein coding gene	Chr10:37055899-37162086 (-)
FVB/NJ	MGP_FVBNJ_G0016993	protein coding gene	Chr10:36561001-36668318 (-)
LP/J	MGP_LPJ_G0017075	protein coding gene	Chr10:38544714-38655875 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017023	protein coding gene	Chr10:42428647-42545799 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017594	protein coding gene	Chr10:38057072-38168356 (-)
PWK/PhJ	MGP_PWKPhJ_G0016278	protein coding gene	Chr10:36917088-37023774 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016062	protein coding gene	Chr10:37876432-37986170 (-)
WSB/EiJ	MGP_WSBEiJ_G0016561	protein coding gene	Chr10:38341513-38462386 (-)

Human Ortholog

SLC16A10, solute carrier family 16 member 10

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC16A10, solute carrier family 16 member 10
Synonyms

MCT10, PRO0813, TAT1
Links

HGNC:17027

NCBI Gene ID: 117247

neXtProt AC: NX_Q8TF71

UniProt: Q8TF71
Chr Location

6q21; chr6:111087503-111231194 (+) GRCh38

MGI Vertebrate Homology

Slc16a10 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC16A10
Gene Tree

Slc16a10

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Phenotype Summary

12 phenotypes from 2 alleles in 2 genetic backgrounds
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

5
Radiation induced

1
Targeted

1
Transposon induced

1
Genomic Mutations

2 involving Slc16a10
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

38 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for an ENU-induced null allele exhibit altered amino acid homeostasis.

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All GO Annotations

38
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

822
Tissues

42
cDNA Data

45
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc16a10

ZFIN slc16a10

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All Sequences

54
RefSeq

7
UniProt

5
CCDS

CCDS48543.1, CCDS87990.1

Ensembl

ENSMUSG00000019838 (Evidence)
NCBI Gene

72472

			Length	Strain/Species	Flank
genomic	ENSMUSG00000019838	Ensembl Gene Model \| MGI Sequence Detail	108727	C57BL/6J	± kb
transcript	ENSMUST00000092566	Ensembl \| MGI Sequence Detail	5397	Not Applicable
polypeptide	ENSMUSP00000090227	Ensembl \| MGI Sequence Detail	512	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000014945 monocarboxylate transporter 10

(term hierarchy)
InterPro Domains

IPR011701 Major facilitator superfamily

IPR020846 Major facilitator superfamily domain

IPR036259 MFS transporter superfamily

IPR050327 Proton-linked Monocarboxylate Transporter

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All nucleic 49

cDNA 45

Primer pair 4

Microarray probesets 4

Summaries

All 61

Developmental Gene Expression 8

Gene Ontology 9

Phenotypes 23
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345710 Hoen E, et al., The Differential Effect of a Shortage of Thyroid Hormone Compared with Knockout of Thyroid Hormone Transporters Mct8 and Mct10 on Murine Macrophage Polarization. Int J Mol Sci. 2024 Feb 9;25(4)

TSS for Slc16a10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr97375	Chr10:40018243-40018256 (-)	4 bp
Tssr97374	Chr10:40011017-40011031 (-)	7,230 bp
Tssr97373	Chr10:40010124-40010128 (-)	8,128 bp
Tssr97372	Chr10:40005571-40005600 (-)	12,668 bp
Tssr97371	Chr10:40005298-40005302 (-)	12,954 bp
Tssr97370	Chr10:40005210-40005224 (-)	13,037 bp
Tssr97369	Chr10:40004957-40005001 (-)	13,275 bp
Tssr97368	Chr10:40004446-40004457 (-)	13,802 bp
Tssr97367	Chr10:40004309-40004341 (-)	13,929 bp
Tssr97366	Chr10:40004217-40004256 (-)	14,017 bp
Tssr97365	Chr10:39975426-39975437 (-)	42,822 bp
Tssr97364	Chr10:39974883-39974901 (-)	43,362 bp
Tssr97363	Chr10:39948988-39948992 (-)	69,264 bp
Tssr97362	Chr10:39948256-39948264 (-)	69,994 bp
Tssr97361	Chr10:39909962-39909987 (-)	108,279 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24