Ssbp3 MGI Mouse Gene Detail - MGI:1919725 - single-stranded DNA binding protein 3

Symbol

Ssbp3
Name

single-stranded DNA binding protein 3
Synonyms

2610021L12Rik, 2610200M23Rik, 5730488C10Rik

Feature Type

protein coding gene
IDs

MGI:1919725
NCBI Gene: 72475
Alliance

gene page
Transcription Start Sites

17 TSS

Sequence Map

Chr4:106768667-106906891 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 49.90 cM, cytoband C7
Mapping Data

3 experiments

SNPs within 2kb

2951 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919725	protein coding gene	Chr4:106767898-106906891 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028528	protein coding gene	Chr4:107568119-107718071 (+)
A/J	MGP_AJ_G0028491	protein coding gene	Chr4:103717729-103857057 (+)
AKR/J	MGP_AKRJ_G0028438	protein coding gene	Chr4:106249923-106392757 (+)
BALB/cJ	MGP_BALBcJ_G0028510	protein coding gene	Chr4:103908176-104048222 (+)
C3H/HeJ	MGP_C3HHeJ_G0028224	protein coding gene	Chr4:106998726-107148189 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028950	protein coding gene	Chr4:111453500-111599402 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026241	protein coding gene	Chr4:98995550-99134029 (+)
CAST/EiJ	MGP_CASTEiJ_G0027660	protein coding gene	Chr4:104812854-104958544 (+)
CBA/J	MGP_CBAJ_G0028193	protein coding gene	Chr4:115058142-115210185 (+)
DBA/2J	MGP_DBA2J_G0028341	protein coding gene	Chr4:103335700-103474659 (+)
FVB/NJ	MGP_FVBNJ_G0028309	protein coding gene	Chr4:102197340-102340561 (+)
LP/J	MGP_LPJ_G0028442	protein coding gene	Chr4:107769515-107915813 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028335	protein coding gene	Chr4:120372600-120513390 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028986	protein coding gene	Chr4:106492514-106633022 (+)
PWK/PhJ	MGP_PWKPhJ_G0027386	protein coding gene	Chr4:101580439-101722697 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027210	protein coding gene	Chr4:103890025-104038086 (+)
WSB/EiJ	MGP_WSBEiJ_G0027741	protein coding gene	Chr4:106673081-106817320 (+)

Human Ortholog

SSBP3, single stranded DNA binding protein 3

Vertebrate Orthologs

6

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SSBP3, single stranded DNA binding protein 3
Synonyms

CSDP, SSDP, SSDP1
Links

HGNC:15674

NCBI Gene ID: 23648

neXtProt AC: NX_Q9BWW4

UniProt: Q9BWW4
Chr Location

1p32.3

MGI Vertebrate Homology

Ssbp3 stringent orthology
1 human;1 mouse;1 rat;4 zebrafish
HCOP

vertebrate homology predictions: SSBP3
Gene Tree

Ssbp3

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Phenotype Summary

11 phenotypes from 2 alleles in 1 genetic background
31 phenotypes from multigenic genotypes
1 images
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

54
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

46
Radiation induced

1
Targeted

3
Transgenic

1
Genomic Mutations

4 involving Ssbp3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

41 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Embryos homozygous for a gene trap mutation that deletes the proline-rich domain show a severe anterior truncation and a lethal headless phenotype (loss of fore- and midbrain). Embryos homozygous for a gene trap mutation which retains most of the proline-rich domain show normal head development.

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All GO Annotations

27
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

768
Tissues

40
cDNA Data

19
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA SSBP3

Xenbase ssbp3

ZFIN ssbp3a, ssbp3b

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All Sequences

106
RefSeq

24
UniProt

8
CCDS

CCDS18427.1, CCDS18428.1

Ensembl

ENSMUSG00000061887 (Evidence)
NCBI Gene

72475

			Length	Strain/Species	Flank
genomic	72475	NCBI Gene Model \| MGI Sequence Detail	138225	C57BL/6J	± kb
transcript	NM_023672	RefSeq \| MGI Sequence Detail	3211	C57BL/6
polypeptide	Q9D032	UniProt \| EBI \| MGI Sequence Detail	388	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000015650 single-stranded DNA-binding protein 3

(term hierarchy)
InterPro Domains

IPR006594 LIS1 homology motif

IPR008116 Sequence-specific single-strand DNA-binding protein
GlyGen

Q9D032 3 sites, 1 O-linked glycan (3 sites)

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All nucleic 21

cDNA 19

Primer pair 1

Other 1

Microarray probesets 5

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MGI:1917840, MGI:1919697, MGI:2140399, MGI:2140595

Summaries

All 50

Developmental Gene Expression 9

Gene Ontology 7

Phenotypes 15
Earliest

J:57548 Raval-Fernandes S, et al., Cloning of a cDNA encoding a sequence-specific single-stranded-DNA-binding protein from Rattus norvegicus. Gene. 1999 Sep 3;237(1):201-7
Latest

J:339475 Toren E, et al., The SSBP3 co-regulator is required for glucose homeostasis, pancreatic islet architecture, and beta-cell identity. Mol Metab. 2023 Aug 1;76:101785

TSS for Ssbp3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr38195	Chr4:106767625-106767631 (+)	-1,039 bp
Tssr38196	Chr4:106768632-106768643 (+)	-29 bp
Tssr38197	Chr4:106768667-106768702 (+)	18 bp
Tssr38198	Chr4:106768714-106768726 (+)	53 bp
Tssr38199	Chr4:106780428-106780473 (+)	11,784 bp
Tssr38200	Chr4:106794518-106794522 (+)	25,853 bp
Tssr38201	Chr4:106804431-106804447 (+)	35,772 bp
Tssr38202	Chr4:106806618-106806627 (+)	37,956 bp
Tssr38203	Chr4:106810710-106810714 (+)	42,045 bp
Tssr38204	Chr4:106859790-106859825 (+)	91,141 bp
Tssr38205	Chr4:106859910-106859923 (+)	91,250 bp
Tssr38206	Chr4:106866897-106866923 (+)	98,243 bp
Tssr38207	Chr4:106893311-106893322 (+)	124,650 bp
Tssr38208	Chr4:106893330-106893349 (+)	124,673 bp
Tssr38209	Chr4:106904628-106904634 (+)	135,964 bp
Tssr38210	Chr4:106905341-106905379 (+)	136,693 bp
Tssr38211	Chr4:106905630-106905645 (+)	136,971 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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