Hsdl2 MGI Mouse Gene Detail - MGI:1919729 - hydroxysteroid dehydrogenase like 2

Symbol

Hsdl2
Name

hydroxysteroid dehydrogenase like 2
Synonyms

2610207I16Rik

Feature Type

protein coding gene
IDs

MGI:1919729
NCBI Gene: 72479
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr4:59581563-59618689 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 32.69 cM, cytoband C1
Mapping Data

3 experiments

SNPs within 2kb

1027 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919729	protein coding gene	Chr4:59581515-59618694 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028337	protein coding gene	Chr4:58491484-58533009 (+)
A/J	MGP_AJ_G0028298	protein coding gene	Chr4:56241171-56279940 (+)
AKR/J	MGP_AKRJ_G0028247	protein coding gene	Chr4:57814824-57852777 (+)
BALB/cJ	MGP_BALBcJ_G0028317	protein coding gene	Chr4:56415747-56453778 (+)
C3H/HeJ	MGP_C3HHeJ_G0028038	protein coding gene	Chr4:58351626-58393771 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028758	protein coding gene	Chr4:60526351-60569350 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026064	protein coding gene	Chr4:52972347-53014430 (+)
CAST/EiJ	MGP_CASTEiJ_G0027476	protein coding gene	Chr4:58070469-58117684 (+)
CBA/J	MGP_CBAJ_G0028003	protein coding gene	Chr4:62587511-62626975 (+)
DBA/2J	MGP_DBA2J_G0028153	protein coding gene	Chr4:56141517-56178208 (+)
FVB/NJ	MGP_FVBNJ_G0028120	protein coding gene	Chr4:55348067-55385525 (+)
LP/J	MGP_LPJ_G0028252	protein coding gene	Chr4:58583931-58622785 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028144	protein coding gene	Chr4:65718473-65755305 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028794	protein coding gene	Chr4:58000940-58038391 (+)
PWK/PhJ	MGP_PWKPhJ_G0027201	protein coding gene	Chr4:56179439-56220971 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027029	protein coding gene	Chr4:57327521-57366560 (+)
WSB/EiJ	MGP_WSBEiJ_G0027554	protein coding gene	Chr4:57989065-58029225 (+)

Human Ortholog

HSDL2, hydroxysteroid dehydrogenase like 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HSDL2, hydroxysteroid dehydrogenase like 2
Synonyms

C9orf99, SDR13C1
Links

HGNC:18572

NCBI Gene ID: 84263

neXtProt AC: NX_Q6YN16

UniProt: Q6YN16
Chr Location

9q32; chr9:112380080-112472405 (+) GRCh38

MGI Vertebrate Homology

Hsdl2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HSDL2
Gene Tree

Hsdl2

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Endonuclease-mediated

1
Gene trapped

1
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

8
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

107

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hsdl2

ZFIN hsdl2

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All Sequences

61
RefSeq

10
UniProt

4
CCDS

CCDS38772.1, CCDS80104.1

Ensembl

ENSMUSG00000028383 (Evidence)
NCBI Gene

72479

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028383	Ensembl Gene Model \| MGI Sequence Detail	37127	C57BL/6J	± kb
transcript	ENSMUST00000030078	Ensembl \| MGI Sequence Detail	2611	Not Applicable
polypeptide	ENSMUSP00000030078	Ensembl \| MGI Sequence Detail	490	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000008789 hydroxysteroid dehydrogenase-like protein 2

(term hierarchy)
EC

1.-.-.-
InterPro Domains

IPR051935 Hydroxysteroid dehydrogenase-like protein 2

IPR036291 NAD(P)-binding domain superfamily

IPR003033 SCP2 sterol-binding domain

IPR036527 SCP2 sterol-binding domain superfamily

IPR002347 Short-chain dehydrogenase/reductase SDR
GlyGen

Q2TPA8 1 site, 1 O-linked glycan (1 site)

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All nucleic 108

cDNA 108

Microarray probesets 6

Summaries

All 33

Gene Ontology 7

Phenotypes 5
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:349365 Samson N, et al., HSDL2 links nutritional cues to bile acid and cholesterol homeostasis. Sci Adv. 2024 May 31;10(22):eadk9681

TSS for Hsdl2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr37433	Chr4:59581522-59581532 (+)	-36 bp
Tssr37434	Chr4:59581543-59581554 (+)	-14 bp
Tssr37435	Chr4:59581557-59581568 (+)	0 bp
Tssr37436	Chr4:59581589-59581600 (+)	32 bp
Tssr37437	Chr4:59581617-59581629 (+)	60 bp
Tssr37438	Chr4:59581675-59581682 (+)	116 bp
Tssr37439	Chr4:59581697-59581714 (+)	143 bp
Tssr37440	Chr4:59581721-59581732 (+)	164 bp
Tssr37441	Chr4:59618285-59618289 (+)	36,724 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24