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Sec24c Gene Detail
Summary
  • Symbol
    Sec24c
  • Name
    SEC24 homolog C, COPII coat complex component
  • Synonyms
    2610204K03Rik, mKIAA0079
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919746
    NCBI Gene: 218811
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:20724376-20744920 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 11.53 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    379 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919746
 protein coding gene Chr14:20722709-20744920 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021042
 protein coding gene Chr14:13439992-13461051 (+)
A/J MGP_AJ_G0020991
 protein coding gene Chr14:13130696-13151159 (+)
AKR/J MGP_AKRJ_G0020968
 protein coding gene Chr14:13656419-13676898 (+)
BALB/cJ MGP_BALBcJ_G0020994
 protein coding gene Chr14:13234308-13255012 (+)
C3H/HeJ MGP_C3HHeJ_G0020778
 protein coding gene Chr14:13594902-13616207 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021427
 protein coding gene Chr14:13940927-13962674 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018995
 protein coding gene Chr14:13445095-13467777 (+)
CAST/EiJ MGP_CASTEiJ_G0020302
 protein coding gene Chr14:13360649-13381053 (+)
CBA/J MGP_CBAJ_G0020744
 protein coding gene Chr14:14651234-14671790 (+)
DBA/2J MGP_DBA2J_G0020867
 protein coding gene Chr14:12954395-12975646 (+)
FVB/NJ MGP_FVBNJ_G0020850
 protein coding gene Chr14:12848279-12868722 (+)
LP/J MGP_LPJ_G0020943
 protein coding gene Chr14:13668039-13688468 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020876
 protein coding gene Chr14:14428979-14449432 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021460
 protein coding gene Chr14:13448170-13468698 (+)
PWK/PhJ MGP_PWKPhJ_G0020051
 protein coding gene Chr14:12524095-12545022 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019873
 protein coding gene Chr14:13242067-13262585 (+)
WSB/EiJ MGP_WSBEiJ_G0020358
 protein coding gene Chr14:13429164-13449685 (+)



Homology
more
  • Human Ortholog
    SEC24C, SEC24 homolog C, COPII coat complex component
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SEC24C, SEC24 homolog C, COPII coat complex component
  • Links
    NCBI Gene ID: 9632
    neXtProt AC: NX_P53992
    UniProt: P53992

  • Chr Location
    10q22.2; chr10:73744372-73772161 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 3 alleles in 6 genetic backgrounds
    1 phenotype from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display complete embryonic lethality between implantation and placentation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    3
  • cDNA Data
    321
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039367 Ensembl Gene Model | MGI Sequence Detail 20545 C57BL/6J ±  kb
transcript ENSMUST00000048657 Ensembl | MGI Sequence Detail 4461 Not Applicable  
polypeptide ENSMUSP00000045955 Ensembl | MGI Sequence Detail 1096 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    12 Sequences
  • InterPro Domains
    IPR029006 ADF-H/Gelsolin-like domain superfamily
    IPR007123 Gelsolin-like domain
    IPR036180 Gelsolin-like domain superfamily
    IPR012990 Sec23/Sec24 beta-sandwich
    IPR050550 SEC23/SEC24 family, SEC24 subfamily
    IPR006900 Sec23/Sec24, helical domain
    IPR036175 Sec23/Sec24 helical domain superfamily
    IPR006896 Sec23/Sec24, trunk domain
    IPR041742 Sec24-like, trunk domain
    IPR036465 von Willebrand factor A-like domain superfamily
    IPR006895 Zinc finger, Sec23/Sec24-type
    IPR036174 Zinc finger, Sec23/Sec24-type superfamily
  • GlyGen
    G3X972 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 322
    cDNA 321
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 33
    Developmental Gene Expression 3
    Gene Ontology 3
    Phenotypes 11
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:312428 Adams EJ, et al., Murine SEC24D can substitute functionally for SEC24C during embryonic development. Sci Rep. 2021 Oct 26;11(1):21100
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory