Fgfbp3 MGI Mouse Gene Detail - MGI:1919764 - fibroblast growth factor binding protein 3

Symbol

Fgfbp3
Name

fibroblast growth factor binding protein 3
Synonyms

2610306H15Rik

Feature Type

protein coding gene
IDs

MGI:1919764
NCBI Gene: 72514
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr19:36894950-36896999 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 32.01 cM
Mapping Data

2 experiments

SNPs within 2kb

190 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919764	protein coding gene	Chr19:36894950-36897015 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025075	protein coding gene	Chr19:35832599-35834663 (-)
A/J	MGP_AJ_G0025051	protein coding gene	Chr19:34114376-34116440 (-)
AKR/J	MGP_AKRJ_G0025019	protein coding gene	Chr19:35271168-35273232 (-)
BALB/cJ	MGP_BALBcJ_G0025049	protein coding gene	Chr19:34199125-34201189 (-)
C3H/HeJ	MGP_C3HHeJ_G0024808	protein coding gene	Chr19:35328259-35330323 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025490	protein coding gene	Chr19:36866245-36868310 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022908	protein coding gene	Chr19:33477780-33479850 (-)
CAST/EiJ	MGP_CASTEiJ_G0024275	protein coding gene	Chr19:35161814-35164607 (-)
CBA/J	MGP_CBAJ_G0024785	protein coding gene	Chr19:38615939-38618003 (-)
DBA/2J	MGP_DBA2J_G0024917	protein coding gene	Chr19:33973120-33975184 (-)
FVB/NJ	MGP_FVBNJ_G0024878	protein coding gene	Chr19:33781885-33783949 (-)
LP/J	MGP_LPJ_G0025003	protein coding gene	Chr19:35930302-35932366 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024909	protein coding gene	Chr19:38436698-38438762 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025548	protein coding gene	Chr19:35361151-35363215 (-)
PWK/PhJ	MGP_PWKPhJ_G0024027	protein coding gene	Chr19:33802893-33804955 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023827	protein coding gene	Chr19:34186687-34188735 (-)
WSB/EiJ	MGP_WSBEiJ_G0024342	protein coding gene	Chr19:35452551-35454615 (-)

Human Ortholog

FGFBP3, fibroblast growth factor binding protein 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FGFBP3, fibroblast growth factor binding protein 3
Synonyms

C10orf13, FGF-BP3
Links

HGNC:23428

NCBI Gene ID: 143282

neXtProt AC: NX_Q8TAT2

UniProt: Q8TAT2
Chr Location

10q23.32; chr10:91906584-91909486 (-) GRCh38

MGI Vertebrate Homology

Fgfbp3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FGFBP3
Gene Tree

Fgfbp3

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Phenotype Summary

2 phenotypes from 2 alleles in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

2
Gene trapped

2
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available

Mice homozygous for a knock-out allele exhibit increased anxiety-related responses.

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All GO Annotations

9
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

830
Tissues

33
cDNA Data

13
Literature Summary

13

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fgfbp3

ZFIN fgfbp3

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All Sequences

37
RefSeq

2
UniProt

3
CCDS

CCDS29774.2

Ensembl

ENSMUSG00000047632 (Evidence)
NCBI Gene

72514

			Length	Strain/Species	Flank
genomic	72514	NCBI Gene Model \| MGI Sequence Detail	2050	C57BL/6J	± kb
transcript	NM_028263	RefSeq \| MGI Sequence Detail	1775	C57BL/6
polypeptide	Q1HCM0	UniProt \| EBI \| MGI Sequence Detail	245	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000007503 fibroblast growth factor-binding protein 3

(term hierarchy)
InterPro Domains

IPR010510 FGF binding 1

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All nucleic 14

cDNA 13

Other 1

Microarray probesets 3

Summaries

All 46

Developmental Gene Expression 13

Gene Ontology 3

Phenotypes 14
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Fgfbp3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr159056	Chr19:36897052-36897059 (-)	-57 bp
Tssr159055	Chr19:36897031-36897046 (-)	-40 bp
Tssr159054	Chr19:36897006-36897022 (-)	-15 bp
Tssr159053	Chr19:36896477-36896534 (-)	493 bp
Tssr159052	Chr19:36896452-36896464 (-)	541 bp
Tssr159051	Chr19:36895648-36895687 (-)	1,331 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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