Zc3h14 MGI Mouse Gene Detail - MGI:1919824 - zinc finger CCCH type containing 14

Symbol

Zc3h14
Name

zinc finger CCCH type containing 14
Synonyms

1010001P15Rik, 1700016A15Rik, 2700069A02Rik

Feature Type

protein coding gene
IDs

MGI:1919824
NCBI Gene: 75553
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr12:98713223-98754012 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 49.88 cM, cytoband F1
Mapping Data

3 experiments

SNPs within 2kb

905 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919824	protein coding gene	Chr12:98708276-98754033 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020008	protein coding gene	Chr12:100149751-100191817 (+)
A/J	MGP_AJ_G0019963	protein coding gene	Chr12:96382887-96425149 (+)
AKR/J	MGP_AKRJ_G0019939	protein coding gene	Chr12:98989317-99030125 (+)
BALB/cJ	MGP_BALBcJ_G0019949	protein coding gene	Chr12:96715752-96757249 (+)
C3H/HeJ	MGP_C3HHeJ_G0019751	protein coding gene	Chr12:99540846-99581656 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020398	protein coding gene	Chr12:103196581-103238379 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018012	protein coding gene	Chr12:93352759-93392094 (+)
CAST/EiJ	MGP_CASTEiJ_G0019297	protein coding gene	Chr12:94589239-94633758 (+)
CBA/J	MGP_CBAJ_G0019723	protein coding gene	Chr12:107032846-107078933 (+)
DBA/2J	MGP_DBA2J_G0019834	protein coding gene	Chr12:95807733-95849813 (+)
FVB/NJ	MGP_FVBNJ_G0019823	protein coding gene	Chr12:94527084-94568274 (+)
LP/J	MGP_LPJ_G0019910	protein coding gene	Chr12:99977913-100019881 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019865	protein coding gene	Chr12:110710331-110753655 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020427	protein coding gene	Chr12:98554014-98596127 (+)
PWK/PhJ	MGP_PWKPhJ_G0019061	protein coding gene	Chr12:90423215-90464878 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018857	protein coding gene	Chr12:92715640-92758103 (+)
WSB/EiJ	MGP_WSBEiJ_G0019351	protein coding gene	Chr12:99385985-99428004 (+)

Human Ortholog

ZC3H14, zinc finger CCCH-type containing 14

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZC3H14, zinc finger CCCH-type containing 14
Synonyms

MRT56, MSUT-2, NY-REN-37, SUT2, UKp68
Links

HGNC:20509

NCBI Gene ID: 79882

neXtProt AC: NX_Q6PJT7

UniProt: Q6PJT7
Chr Location

14q31.3; chr14:88562970-88627596 (+) GRCh38

MGI Vertebrate Homology

Zc3h14 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ZC3H14
Gene Tree

Zc3h14

Diseases

1 with human ZC3H14 associations

				Human Disease	Mouse Models
				autosomal recessive intellectual developmental disorder 56 IDs autosomal recessive intellectual developmental disorder 56 DOID:0081217 OMIM:617125

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

20
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

14
Targeted

4
Genomic Mutations

1 involving Zc3h14
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

50 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous knockout results in impaired spatial working memory, enlarged anterior lateral ventricles in the brain, small testes and reduced litter size.

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All GO Annotations

21
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

707
Tissues

1
cDNA Data

14
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase zc3h14

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All Sequences

120
RefSeq

35
UniProt

5
CCDS

CCDS26099.1, CCDS26100.1, CCDS49138.1, CCDS49139.1

Ensembl

ENSMUSG00000021012 (Evidence)
NCBI Gene

75553

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021012	Ensembl Gene Model \| MGI Sequence Detail	40790	C57BL/6J	± kb
transcript	ENSMUST00000110105	Ensembl \| MGI Sequence Detail	3514	Not Applicable
polypeptide	ENSMUSP00000105732	Ensembl \| MGI Sequence Detail	735	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000017599 zinc finger CCCH domain-containing protein 14

(term hierarchy)
InterPro Domains

IPR040366 Nuclear polyadenylated RNA-binding protein Nab2/ZC3H14

IPR000571 Zinc finger, CCCH-type
GlyGen

Q8BJ05 8 sites, 1 O-linked glycan (8 sites)

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All nucleic 17

Genomic 2

cDNA 14

Other 1

Microarray probesets 7

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MGI:1915653, MGI:1922803, MGI:2144932

Summaries

All 49

Developmental Gene Expression 1

Gene Ontology 8

Phenotypes 17
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Zc3h14:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114650	Chr12:98713194-98713305 (+)	27 bp
Tssr114651	Chr12:98713720-98713726 (+)	500 bp
Tssr114652	Chr12:98721265-98721270 (+)	8,045 bp
Tssr3917	Chr12:98737262-98737269 (+)	24,043 bp
Tssr114653	Chr12:98737277-98737300 (+)	24,066 bp
Tssr114654	Chr12:98737309-98737323 (+)	24,093 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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