Zup1 MGI Mouse Gene Detail - MGI:1919830 - zinc finger containing ubiquitin peptidase 1

Symbol

Zup1
Name

zinc finger containing ubiquitin peptidase 1
Synonyms

2700019D07Rik, Zufsp

Feature Type

protein coding gene
IDs

MGI:1919830
NCBI Gene: 72580
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr10:33795138-33827265 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 18.85 cM, cytoband B1
Mapping Data

3 experiments

SNPs within 2kb

989 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919830	protein coding gene	Chr10:33795138-33827316 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017130	protein coding gene	Chr10:32254706-32280122 (-)
A/J	MGP_AJ_G0017107	protein coding gene	Chr10:31400976-31434256 (-)
AKR/J	MGP_AKRJ_G0017067	protein coding gene	Chr10:31766939-31798851 (-)
BALB/cJ	MGP_BALBcJ_G0017070	protein coding gene	Chr10:31339927-31375028 (-)
C3H/HeJ	MGP_C3HHeJ_G0016890	protein coding gene	Chr10:32064025-32097139 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017528	protein coding gene	Chr10:33177084-33202226 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015225	protein coding gene	Chr10:29758123-29783211 (-)
CAST/EiJ	MGP_CASTEiJ_G0016469	protein coding gene	Chr10:32186278-32218474 (-)
CBA/J	MGP_CBAJ_G0016864	protein coding gene	Chr10:34777695-34809495 (-)
DBA/2J	MGP_DBA2J_G0016969	protein coding gene	Chr10:30984811-31017325 (-)
FVB/NJ	MGP_FVBNJ_G0016964	protein coding gene	Chr10:30490409-30525073 (-)
LP/J	MGP_LPJ_G0017046	protein coding gene	Chr10:32242508-32267366 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016994	protein coding gene	Chr10:35247954-35295230 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017564	protein coding gene	Chr10:31720768-31745037 (-)
PWK/PhJ	MGP_PWKPhJ_G0016251	protein coding gene	Chr10:30756383-30781007 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016034	protein coding gene	Chr10:31604145-31627643 (-)
WSB/EiJ	MGP_WSBEiJ_G0016532	protein coding gene	Chr10:31928398-31952614 (-)

Human Ortholog

ZUP1, zinc finger containing ubiquitin peptidase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZUP1, zinc finger containing ubiquitin peptidase 1
Synonyms

C6orf113, DUB, ZUFSP
Links

HGNC:21224

NCBI Gene ID: 221302

neXtProt AC: NX_Q96AP4

UniProt: Q96AP4
Chr Location

6q22.1; chr6:116635618-116668794 (-) GRCh38

MGI Vertebrate Homology

Zup1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ZUP1
Gene Tree

Zup1

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

1
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Zup1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

34 strains or lines available

Mice homozygous for a null allele display increased susceptibility to RNA virus infection.

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All GO Annotations

8
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

714
Tissues

8
cDNA Data

50
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase zup1

ZFIN zufsp

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All Sequences

80
RefSeq

17
UniProt

6
CCDS

CCDS23772.1, CCDS87987.1

Ensembl

ENSMUSG00000039531 (Evidence)
NCBI Gene

72580

			Length	Strain/Species	Flank
genomic	ENSMUSG00000039531	Ensembl Gene Model \| MGI Sequence Detail	32128	C57BL/6J	± kb
transcript	ENSMUST00000218055	Ensembl \| MGI Sequence Detail	2180	Not Applicable
polypeptide	ENSMUSP00000151811	Ensembl \| MGI Sequence Detail	577	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000032730 zinc finger-containing ubiquitin peptidase 1

(term hierarchy)
EC

3.4.19.12
InterPro Domains

IPR012462 UfSP1/2/DUB, catalytic domain

IPR050688 Zinc finger and ubiquitin peptidase domain-containing protein

IPR013087 Zinc finger C2H2-type

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All nucleic 51

cDNA 50

Primer pair 1

Microarray probesets 2

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MGI:6156406

Summaries

All 37

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 13
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:350802 Li T, et al., MAVS promotes interferon signaling in RNA virus infection by ZUFSP-mediated chromatin regulation. Int Immunopharmacol. 2024 Mar 8;131:111819

TSS for Zup1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr97245	Chr10:33827186-33827259 (-)	42 bp
Tssr97244	Chr10:33825485-33825498 (-)	1,773 bp
Tssr97243	Chr10:33823804-33823809 (-)	3,458 bp
Tssr97242	Chr10:33815879-33815895 (-)	11,378 bp
Tssr97241	Chr10:33813609-33813651 (-)	13,635 bp
Tssr97240	Chr10:33812623-33812647 (-)	14,630 bp
Tssr97239	Chr10:33809390-33809402 (-)	17,869 bp
Tssr97238	Chr10:33809197-33809218 (-)	18,057 bp
Tssr97237	Chr10:33809173-33809185 (-)	18,086 bp
Tssr97236	Chr10:33809155-33809166 (-)	18,104 bp
Tssr97235	Chr10:33809127-33809144 (-)	18,129 bp
Tssr97234	Chr10:33809064-33809084 (-)	18,191 bp
Tssr97233	Chr10:33803023-33803037 (-)	24,235 bp
Tssr97232	Chr10:33800658-33800673 (-)	26,599 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24