Pan3 MGI Mouse Gene Detail - MGI:1919837 - PAN3 poly(A) specific ribonuclease subunit

Symbol

Pan3
Name

PAN3 poly(A) specific ribonuclease subunit
Synonyms

2700050F09Rik, A430027N15Rik

Feature Type

protein coding gene
IDs

MGI:1919837
NCBI Gene: 72587
Alliance

gene page
Transcription Start Sites

19 TSS

Sequence Map

Chr5:147366971-147485312 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 86.93 cM, cytoband G2
Mapping Data

3 experiments

SNPs within 2kb

2712 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919837	protein coding gene	Chr5:147363018-147485312 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030390	protein coding gene	Chr5:153095618-153229685 (+)
A/J	MGP_AJ_G0030363	protein coding gene	Chr5:146600747-146721377 (+)
AKR/J	MGP_AKRJ_G0030290	protein coding gene	Chr5:151104028-151235163 (+)
BALB/cJ	MGP_BALBcJ_G0030372	protein coding gene	Chr5:147813014-147934065 (+)
C3H/HeJ	MGP_C3HHeJ_G0030086	protein coding gene	Chr5:152075468-152200957 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030827	protein coding gene	Chr5:158685761-158824361 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028040	protein coding gene	Chr5:141012591-141133829 (+)
CAST/EiJ	MGP_CASTEiJ_G0029488	protein coding gene	Chr5:151646381-151775136 (+)
CBA/J	MGP_CBAJ_G0030064	protein coding gene	Chr5:165327247-165476844 (+)
DBA/2J	MGP_DBA2J_G0030208	protein coding gene	Chr5:146281526-146403432 (+)
FVB/NJ	MGP_FVBNJ_G0030162	protein coding gene	Chr5:145486368-145606267 (+)
LP/J	MGP_LPJ_G0030295	protein coding gene	Chr5:153791741-153915904 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030198	protein coding gene	Chr5:167582195-167709743 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030857	protein coding gene	Chr5:151016956-151140519 (+)
PWK/PhJ	MGP_PWKPhJ_G0029202	protein coding gene	Chr5:145381459-145503054 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029038	protein coding gene	Chr5:148341375-148471380 (+)
WSB/EiJ	MGP_WSBEiJ_G0029565	protein coding gene	Chr5:151824617-151953952 (+)

Human Ortholog

PAN3, poly(A) specific ribonuclease subunit PAN3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PAN3, poly(A) specific ribonuclease subunit PAN3
Links

HGNC:29991

NCBI Gene ID: 255967

neXtProt AC: NX_Q58A45

UniProt: Q58A45
Chr Location

13q12.2; chr13:28138193-28295335 (+) GRCh38

MGI Vertebrate Homology

Pan3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PAN3
Gene Tree

Pan3

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

1
Gene trapped

11
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

45 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

23
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

11
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pan3

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All Sequences

121
RefSeq

40
UniProt

9
CCDS

CCDS39401.2

Ensembl

ENSMUSG00000029647 (Evidence)
NCBI Gene

72587

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029647	Ensembl Gene Model \| MGI Sequence Detail	118342	C57BL/6J	± kb
transcript	ENSMUST00000176600	Ensembl \| MGI Sequence Detail	5541	Not Applicable
polypeptide	ENSMUSP00000135367	Ensembl \| MGI Sequence Detail	887	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000012254 PAN2-PAN3 deadenylation complex subunit PAN3

(term hierarchy)
InterPro Domains

IPR030844 PAN2-PAN3 deadenylation complex subunit PAN3

IPR041332 Pan3 pseudokinase domain

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR000571 Zinc finger, CCCH-type

IPR036855 Zinc finger, CCCH-type superfamily
GlyGen

Q640Q5 1 site, 1 O-linked glycan (1 site)

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All nucleic 14

cDNA 14

Microarray probesets 7

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MGI:2141025, MGI:2443274

Summaries

All 39

Developmental Gene Expression 1

Gene Ontology 9

Phenotypes 9
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Pan3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr49818	Chr5:147366771-147366789 (+)	-191 bp
Tssr49819	Chr5:147366963-147367027 (+)	24 bp
Tssr49820	Chr5:147367032-147367054 (+)	72 bp
Tssr49821	Chr5:147367100-147367112 (+)	135 bp
Tssr49822	Chr5:147367187-147367211 (+)	228 bp
Tssr49823	Chr5:147367217-147367355 (+)	315 bp
Tssr49824	Chr5:147367540-147367553 (+)	576 bp
Tssr49825	Chr5:147367648-147367673 (+)	690 bp
Tssr49826	Chr5:147368402-147368408 (+)	1,434 bp
Tssr49827	Chr5:147368823-147368827 (+)	1,854 bp
Tssr49829	Chr5:147405272-147405281 (+)	38,306 bp
Tssr49830	Chr5:147424935-147424955 (+)	57,974 bp
Tssr49831	Chr5:147437531-147437534 (+)	70,562 bp
Tssr49832	Chr5:147442980-147442983 (+)	76,011 bp
Tssr49833	Chr5:147450555-147450558 (+)	83,586 bp
Tssr49834	Chr5:147456507-147456530 (+)	89,548 bp
Tssr49835	Chr5:147483326-147483345 (+)	116,365 bp
Tssr49836	Chr5:147483404-147483410 (+)	116,436 bp
Tssr49837	Chr5:147484880-147484884 (+)	117,911 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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