Usp13 MGI Mouse Gene Detail - MGI:1919857 - ubiquitin specific peptidase 13 (isopeptidase T-3)

Symbol

Usp13
Name

ubiquitin specific peptidase 13 (isopeptidase T-3)
Synonyms

2700071E21Rik, IsoT-3, ISOT3

Feature Type

protein coding gene
IDs

MGI:1919857
NCBI Gene: 72607
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr3:32871695-32992220 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 15.88 cM
Mapping Data

2 experiments

SNPs within 2kb

3910 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919857	protein coding gene	Chr3:32870432-32992224 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027144	protein coding gene	Chr3:30442316-30568707 (+)
A/J	MGP_AJ_G0027104	protein coding gene	Chr3:30011458-30136645 (+)
AKR/J	MGP_AKRJ_G0027073	protein coding gene	Chr3:30482843-30617103 (+)
BALB/cJ	MGP_BALBcJ_G0027116	protein coding gene	Chr3:29658613-29778854 (+)
C3H/HeJ	MGP_C3HHeJ_G0026859	protein coding gene	Chr3:30506384-30643640 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027562	protein coding gene	Chr3:31956024-32087786 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024923	protein coding gene	Chr3:27808010-27922669 (+)
CAST/EiJ	MGP_CASTEiJ_G0026312	protein coding gene	Chr3:30373412-30495523 (+)
CBA/J	MGP_CBAJ_G0026836	protein coding gene	Chr3:32818871-32958478 (+)
DBA/2J	MGP_DBA2J_G0026970	protein coding gene	Chr3:29472731-29598721 (+)
FVB/NJ	MGP_FVBNJ_G0026938	protein coding gene	Chr3:28930156-29052322 (+)
LP/J	MGP_LPJ_G0027082	protein coding gene	Chr3:31210779-31337444 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026958	protein coding gene	Chr3:35303858-35440548 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027621	protein coding gene	Chr3:30274299-30410659 (+)
PWK/PhJ	MGP_PWKPhJ_G0026045	protein coding gene	Chr3:29008969-29137049 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025857	protein coding gene	Chr3:29697050-29836144 (+)
WSB/EiJ	MGP_WSBEiJ_G0026386	protein coding gene	Chr3:30293550-30418980 (+)

Human Ortholog

USP13, ubiquitin specific peptidase 13

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

USP13, ubiquitin specific peptidase 13
Synonyms

IsoT-3, ISOT3
Links

HGNC:12611

NCBI Gene ID: 8975

neXtProt AC: NX_Q92995

UniProt: Q92995
Chr Location

3q26.33; chr3:179653032-179804366 (+) GRCh38

MGI Vertebrate Homology

Usp13 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: USP13
Protein SuperFamily

UBP
Gene Tree

Usp13

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References

1 with disease annotations

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Phenotype Summary

7 phenotypes from 2 alleles in 2 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

4
Radiation induced

1
Targeted

4
Genomic Mutations

1 involving Usp13
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

46 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit increased susceptibility to LPS- or Pseudomonas aeruginosa (strain PA103)- induced lung inflammation and injury.

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All GO Annotations

41
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

6

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase usp13

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All Sequences

43
RefSeq

5
UniProt

4
CCDS

CCDS17301.1

Ensembl

ENSMUSG00000056900 (Evidence)
NCBI Gene

72607

			Length	Strain/Species	Flank
genomic	ENSMUSG00000056900	Ensembl Gene Model \| MGI Sequence Detail	120526	C57BL/6J	± kb
transcript	ENSMUST00000072312	Ensembl \| MGI Sequence Detail	7580	Not Applicable
polypeptide	ENSMUSP00000072155	Ensembl \| MGI Sequence Detail	858	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000017149 ubiquitin carboxyl-terminal hydrolase 13

(term hierarchy)
EC

3.4.19.12
InterPro Domains

IPR038765 Papain-like cysteine peptidase superfamily

IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase

IPR009060 UBA-like superfamily

IPR015940 Ubiquitin-associated domain

IPR050185 Ubiquitin carboxyl-terminal hydrolase

IPR018200 Ubiquitin specific protease, conserved site

IPR028889 Ubiquitin specific protease domain

IPR016652 Ubiquitinyl hydrolase

IPR041432 Ubiquitinyl hydrolase, variant UBP zinc finger

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001607 Zinc finger, UBP-type

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All nucleic 6

cDNA 6

Microarray probesets 4

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MGI:2139812

Summaries

All 45

Diseases 1

Gene Ontology 8

Phenotypes 13
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Usp13:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr28771	Chr3:32871669-32871725 (+)	2 bp
Tssr28772	Chr3:32871731-32871754 (+)	48 bp
Tssr28773	Chr3:32871755-32871786 (+)	76 bp
Tssr28774	Chr3:32871791-32871810 (+)	106 bp
Tssr28775	Chr3:32872494-32872495 (+)	800 bp
Tssr28776	Chr3:32874347-32874349 (+)	2,653 bp
Tssr856	Chr3:32959862-32959866 (+)	88,169 bp
Tssr857	Chr3:32960898-32960901 (+)	89,205 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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