About   Help   FAQ
Eme2 Gene Detail
Summary
  • Symbol
    Eme2
  • Name
    essential meiotic structure-specific endonuclease subunit 2
  • Synonyms
    2810013J18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919889
    NCBI Gene: 193838
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:25111126-25114061 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 12.53 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    102 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919889
 protein coding gene Chr17:25107460-25114061 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023329
 protein coding gene Chr17:23913907-23920418 (-)
A/J MGP_AJ_G0023289
 protein coding gene Chr17:23250696-23257207 (-)
AKR/J MGP_AKRJ_G0023256
 protein coding gene Chr17:23339195-23345706 (-)
BALB/cJ MGP_BALBcJ_G0023294
 protein coding gene Chr17:23451161-23457749 (-)
C3H/HeJ MGP_C3HHeJ_G0023054
 protein coding gene Chr17:23703793-23711044 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023737
 protein coding gene Chr17:24976796-24983397 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021212
 protein coding gene Chr17:20710934-20717440 (-)
CAST/EiJ MGP_CASTEiJ_G0022556
 protein coding gene Chr17:23559073-23565584 (-)
CBA/J MGP_CBAJ_G0023030
 protein coding gene Chr17:25818083-25827807 (-)
DBA/2J MGP_DBA2J_G0023159
 protein coding gene Chr17:22843359-22850044 (-)
FVB/NJ MGP_FVBNJ_G0023129
 protein coding gene Chr17:22563890-22570401 (-)
LP/J MGP_LPJ_G0023236
 protein coding gene Chr17:24219170-24225681 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023148
 protein coding gene Chr17:25510584-25517095 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023775
 protein coding gene Chr17:23623700-23630211 (-)
PWK/PhJ MGP_PWKPhJ_G0022305
 protein coding gene Chr17:21598754-21605359 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022123
 protein coding gene Chr17:21687979-21694513 (-)
WSB/EiJ MGP_WSBEiJ_G0022619
 protein coding gene Chr17:23696335-23702780 (-)



Homology
more
  • Human Ortholog
    EME2, essential meiotic structure-specific endonuclease subunit 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EME2, essential meiotic structure-specific endonuclease subunit 2
  • Synonyms
    gs125, SLX2B
  • Links
    NCBI Gene ID: 197342
    neXtProt AC: NX_A4GXA9
    UniProt: A4GXA9

  • Chr Location
    16p13.3; chr16:1772810-1781708 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    1
  • cDNA Data
    3
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 193838 NCBI Gene Model | MGI Sequence Detail 2936 C57BL/6J ±  kb
transcript NM_001163102 RefSeq | MGI Sequence Detail 1521 C57BL/6  
polypeptide Q56A04 UniProt | EBI | MGI Sequence Detail 373 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 4
    cDNA 3
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 23
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 2
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:297664 Simonson L, et al., Keratin 13 deficiency causes white sponge nevus in mice. Dev Biol. 2020 Dec 1;468(1-2):146-153
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory