Mex3a MGI Mouse Gene Detail - MGI:1919890 - mex3 RNA binding family member A

Symbol

Mex3a
Name

mex3 RNA binding family member A
Synonyms

2700083E18Rik, Rkhd4

Feature Type

protein coding gene
IDs

MGI:1919890
NCBI Gene: 72640
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr3:88439702-88448703 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 38.86 cM
Mapping Data

3 experiments

SNPs within 2kb

183 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919890	protein coding gene	Chr3:88439253-88448703 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027399	protein coding gene	Chr3:88699247-88709695 (+)
A/J	MGP_AJ_G0027363	protein coding gene	Chr3:85706547-85715581 (+)
AKR/J	MGP_AKRJ_G0027327	protein coding gene	Chr3:87821285-87831194 (+)
BALB/cJ	MGP_BALBcJ_G0027372	protein coding gene	Chr3:85793439-85802474 (+)
C3H/HeJ	MGP_C3HHeJ_G0027114	protein coding gene	Chr3:88079127-88088161 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027818	protein coding gene	Chr3:91999740-92009865 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025170	protein coding gene	Chr3:81307599-81316983 (+)
CAST/EiJ	MGP_CASTEiJ_G0026560	protein coding gene	Chr3:88320792-88331357 (+)
CBA/J	MGP_CBAJ_G0027088	protein coding gene	Chr3:95166518-95180689 (+)
DBA/2J	MGP_DBA2J_G0027226	protein coding gene	Chr3:85192046-85201038 (+)
FVB/NJ	MGP_FVBNJ_G0027194	protein coding gene	Chr3:83460838-83469786 (+)
LP/J	MGP_LPJ_G0027335	protein coding gene	Chr3:89710793-89719834 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027214	protein coding gene	Chr3:101376169-101387307 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027877	protein coding gene	Chr3:87568164-87578242 (+)
PWK/PhJ	MGP_PWKPhJ_G0026294	protein coding gene	Chr3:84969032-84979330 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026113	protein coding gene	Chr3:86752781-86763754 (+)
WSB/EiJ	MGP_WSBEiJ_G0026642	protein coding gene	Chr3:87923841-87932832 (+)

Human Ortholog

MEX3A, mex-3 RNA binding family member A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MEX3A, mex-3 RNA binding family member A
Synonyms

MEX-3A, RKHD4, RNF162
Links

HGNC:33482

NCBI Gene ID: 92312

neXtProt AC: NX_A1L020

UniProt: A1L020
Chr Location

1q22; chr1:156072013-156082465 (-) GRCh38

MGI Vertebrate Homology

Mex3a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MEX3A
Gene Tree

Mex3a

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References

1 with disease annotations

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Phenotype Summary

17 phenotypes from 1 allele in 1 genetic background
3 phenotypes from multigenic genotypes
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

11
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Mex3a
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit partial prenatal and postnatal lethality, with 60% of mice showing weight loss, dehydration and lethargy, impaired intestinal crypt development and altered intestinal crypt-villus architecture.

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All GO Annotations

3
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

752
Tissues

32
cDNA Data

13
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mex3a

ZFIN mex3a

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All Sequences

35
RefSeq

2
UniProt

1
CCDS

CCDS17476.1

Ensembl

ENSMUSG00000074480 (Evidence)
NCBI Gene

72640

			Length	Strain/Species	Flank
genomic	ENSMUSG00000074480	Ensembl Gene Model \| MGI Sequence Detail	9002	C57BL/6J	± kb
transcript	ENSMUST00000172699	Ensembl \| MGI Sequence Detail	5778	Not Applicable
polypeptide	ENSMUSP00000134222	Ensembl \| MGI Sequence Detail	520	Not Applicable

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UniProt

1 Sequence
InterPro Domains

IPR004087 K Homology domain

IPR004088 K Homology domain, type 1

IPR036612 K Homology domain, type 1 superfamily

IPR047227 RNA-binding protein MEX3

IPR047228 RNA-binding protein MEX-3, first type I KH domain

IPR047226 RNA-binding protein MEX-3, second type I KH domain

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type

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All nucleic 15

cDNA 13

Primer pair 1

Other 1

Microarray probesets 5

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MGI:2685257, MGI:3034693

Summaries

All 42

Developmental Gene Expression 5

Diseases 1

Gene Ontology 1

Phenotypes 12
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:336789 Domingo-Muelas A, et al., Post-transcriptional control of a stemness signature by RNA-binding protein MEX3A regulates murine adult neurogenesis. Nat Commun. 2023 Jan 23;14(1):373

TSS for Mex3a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr29954	Chr3:88438801-88438834 (+)	-884 bp
Tssr29955	Chr3:88438836-88438852 (+)	-858 bp
Tssr29956	Chr3:88439211-88439302 (+)	-445 bp
Tssr29957	Chr3:88439621-88439703 (+)	-40 bp
Tssr29958	Chr3:88440019-88440072 (+)	344 bp
Tssr29959	Chr3:88444637-88444645 (+)	4,939 bp
Tssr29960	Chr3:88444671-88444684 (+)	4,976 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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