Hnrnpll MGI Mouse Gene Detail - MGI:1919942 - heterogeneous nuclear ribonucleoprotein L-like

Symbol

Hnrnpll
Name

heterogeneous nuclear ribonucleoprotein L-like
Synonyms

2510028H02Rik, 2810036L13Rik, Hnrpll

Feature Type

protein coding gene
IDs

MGI:1919942
NCBI Gene: 72692
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr17:80336916-80369697 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 50.30 cM
Mapping Data

2 experiments

SNPs within 2kb

909 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919942	protein coding gene	Chr17:80336916-80369697 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024055	protein coding gene	Chr17:82915792-82949272 (-)
A/J	MGP_AJ_G0024012	protein coding gene	Chr17:80376831-80410633 (-)
AKR/J	MGP_AKRJ_G0023981	protein coding gene	Chr17:81623224-81656803 (-)
BALB/cJ	MGP_BALBcJ_G0024014	protein coding gene	Chr17:80257223-80290767 (-)
C3H/HeJ	MGP_C3HHeJ_G0023778	protein coding gene	Chr17:82506605-82540130 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024458	protein coding gene	Chr17:85941604-85977199 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021900	protein coding gene	Chr17:75757787-75791074 (-)
CAST/EiJ	MGP_CASTEiJ_G0023258	protein coding gene	Chr17:83175739-83209178 (-)
CBA/J	MGP_CBAJ_G0023752	protein coding gene	Chr17:89513698-89551282 (-)
DBA/2J	MGP_DBA2J_G0023881	protein coding gene	Chr17:78891230-78924572 (-)
FVB/NJ	MGP_FVBNJ_G0023847	protein coding gene	Chr17:78384219-78420540 (-)
LP/J	MGP_LPJ_G0023964	protein coding gene	Chr17:83765725-83799534 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023875	protein coding gene	Chr17:89585878-89622875 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024503	protein coding gene	Chr17:82099014-82140943 (-)
PWK/PhJ	MGP_PWKPhJ_G0023004	protein coding gene	Chr17:78413813-78450537 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022815	protein coding gene	Chr17:78892690-78927283 (-)
WSB/EiJ	MGP_WSBEiJ_G0023325	protein coding gene	Chr17:82929617-82964615 (-)

Human Ortholog

HNRNPLL, heterogeneous nuclear ribonucleoprotein L like

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HNRNPLL, heterogeneous nuclear ribonucleoprotein L like
Synonyms

HNRPLL, SRRF
Links

HGNC:25127

NCBI Gene ID: 92906

neXtProt AC: NX_Q8WVV9

UniProt: Q8WVV9
Chr Location

2p22.1; chr2:38561969-38603586 (-) GRCh38

MGI Vertebrate Homology

Hnrnpll stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: HNRNPLL
Gene Tree

Hnrnpll

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (ENU)

1
Endonuclease-mediated

3
Gene trapped

9
Targeted

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

44 strains or lines available

Mice homozygous for a point mutation in a RNA recognition motif of the gene product have defects in the generation of alternative transcripts normally found in memory T cells. Total CD4⁺ T cell counts are lower, with a reduction of nave CD44^lo T cells occurring as mice age.

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All GO Annotations

12
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

728
Tissues

22
cDNA Data

110
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hnrnpll

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All Sequences

59
RefSeq

3
UniProt

5
CCDS

CCDS70845.1

Ensembl

ENSMUSG00000024095 (Evidence)
NCBI Gene

72692

			Length	Strain/Species	Flank
genomic	72692	NCBI Gene Model \| MGI Sequence Detail	32782	C57BL/6J	± kb
transcript	NR_152119	RefSeq \| MGI Sequence Detail	3133	C57BL/6
polypeptide	Q921F4	UniProt \| EBI \| MGI Sequence Detail	591	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000008677 heterogeneous nuclear ribonucleoprotein L-like

(term hierarchy)
PDB

1WEX, 2E5I
InterPro Domains

IPR006536 HnRNP-L/PTB

IPR034985 hnRPLL, RNA recognition motif 1

IPR034986 hnRPLL, RNA recognition motif 2

IPR034983 hnRPLL, RNA recognition motif 3

IPR034987 hnRPLL, RNA recognition motif 4

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR021790 PTBP1-like, RNA recognition motif 2

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain
GlyGen

Q921F4 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 113

cDNA 112

Primer pair 1

Microarray probesets 6

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MGI:1919699, MGI:2146812, MGI:2146941

Summaries

All 48

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 13
Earliest

J:53501 Borchert A, et al., Cloning of the mouse phospholipid hydroperoxide glutathione peroxidase gene. FEBS Lett. 1999 Mar 12;446(2-3):223-7
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Hnrnpll:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr149480	Chr17:80370005-80370014 (-)	-313 bp
Tssr149479	Chr17:80369762-80369792 (-)	-80 bp
Tssr149478	Chr17:80369733-80369758 (-)	-49 bp
Tssr149477	Chr17:80369628-80369676 (-)	45 bp
Tssr149476	Chr17:80369604-80369618 (-)	86 bp
Tssr149475	Chr17:80369546-80369572 (-)	138 bp
Tssr149474	Chr17:80369504-80369515 (-)	187 bp
Tssr149473	Chr17:80368428-80368440 (-)	1,263 bp
Tssr149472	Chr17:80362798-80362807 (-)	6,894 bp
Tssr149471	Chr17:80360791-80360797 (-)	8,903 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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