Lime1 MGI Mouse Gene Detail - MGI:1919949 - Lck interacting transmembrane adaptor 1

Symbol

Lime1
Name

Lck interacting transmembrane adaptor 1
Synonyms

2810038K19Rik, LIME

Feature Type

protein coding gene
IDs

MGI:1919949
NCBI Gene: 72699
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr2:181023028-181025421 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 103.63 cM, cytoband H4
Mapping Data

2 experiments

SNPs within 2kb

116 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919949	protein coding gene	Chr2:181021871-181025421 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027022	protein coding gene	Chr2:187969084-187972634 (+)
A/J	MGP_AJ_G0026988	protein coding gene	Chr2:180232169-180235719 (+)
AKR/J	MGP_AKRJ_G0026959	protein coding gene	Chr2:185634664-185638214 (+)
BALB/cJ	MGP_BALBcJ_G0026997	protein coding gene	Chr2:180705003-180708553 (+)
C3H/HeJ	MGP_C3HHeJ_G0026738	protein coding gene	Chr2:185987121-185990671 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027443	protein coding gene	Chr2:193398152-193401702 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024807	protein coding gene	Chr2:170913949-170917495 (+)
CAST/EiJ	MGP_CASTEiJ_G0026197	protein coding gene	Chr2:184252371-184255918 (+)
CBA/J	MGP_CBAJ_G0026715	protein coding gene	Chr2:200407243-200410793 (+)
DBA/2J	MGP_DBA2J_G0026853	protein coding gene	Chr2:179330173-179333723 (+)
FVB/NJ	MGP_FVBNJ_G0026819	protein coding gene	Chr2:177947627-177951185 (+)
LP/J	MGP_LPJ_G0026954	protein coding gene	Chr2:187993125-187996675 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026838	protein coding gene	Chr2:202967129-202970679 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027502	protein coding gene	Chr2:185602398-185605948 (+)
PWK/PhJ	MGP_PWKPhJ_G0025933	protein coding gene	Chr2:176854029-176857574 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025733	protein coding gene	Chr2:182105923-182109467 (+)
WSB/EiJ	MGP_WSBEiJ_G0026269	protein coding gene	Chr2:186589462-186593050 (+)

Human Ortholog

LIME1, Lck interacting transmembrane adaptor 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LIME1, Lck interacting transmembrane adaptor 1
Synonyms

dJ583P15.4, LIME
Links

HGNC:26016

NCBI Gene ID: 54923

neXtProt AC: NX_Q9H400

UniProt: Q9H400
Chr Location

20q13.33; chr20:63735701-63739103 (+) GRCh38

MGI Vertebrate Homology

Lime1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: LIME1
Gene Tree

Lime1

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Phenotype Summary

2 phenotypes from 2 alleles in 2 genetic backgrounds
4 phenotypes from multigenic genotypes
4 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

2
Endonuclease-mediated

1
Targeted

1
Incidental Mutations

CvDC
Find Mice (IMSR)

6 strains or lines available

Mice homozygous for a targeted null allele exhibit no detectable abnormalities in the development and function of B and T cells.

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All GO Annotations

17
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

759
Tissues

8
cDNA Data

54
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

46
RefSeq

2
UniProt

5
CCDS

CCDS17211.1

Ensembl

ENSMUSG00000090077 (Evidence)
NCBI Gene

72699

			Length	Strain/Species	Flank
genomic	72699	NCBI Gene Model \| MGI Sequence Detail	2394	C57BL/6J	± kb
transcript	NM_023684	RefSeq \| MGI Sequence Detail	1987	Not Specified
polypeptide	Q9EQR5	UniProt \| EBI \| MGI Sequence Detail	269	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000009815 lck-interacting transmembrane adapter 1

(term hierarchy)
InterPro Domains

IPR026072 Lck-interacting transmembrane adapter 1

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All nucleic 54

cDNA 54

Microarray probesets 4

Summaries

All 30

Developmental Gene Expression 3

Gene Ontology 4

Phenotypes 4
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034

TSS for Lime1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr22310	Chr2:181023100-181023158 (+)	101 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24