About   Help   FAQ
Ttc39c Gene Detail
Summary
  • Symbol
    Ttc39c
  • Name
    tetratricopeptide repeat domain 39C
  • Synonyms
    1700008N02Rik, 2810439F02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919997
    NCBI Gene: 72747
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:12732953-12871920 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 6.71 cM, cytoband A2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4227 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919997
 protein coding gene Chr18:12716168-12872461 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024161
 protein coding gene Chr18:9847569-9944889 (+)
A/J MGP_AJ_G0024123
 protein coding gene Chr18:9648649-9742450 (+)
AKR/J MGP_AKRJ_G0024090
 protein coding gene Chr18:9943875-10043421 (+)
BALB/cJ MGP_BALBcJ_G0024122
 protein coding gene Chr18:9600029-9696084 (+)
C3H/HeJ MGP_C3HHeJ_G0023889
 protein coding gene Chr18:9826225-9928442 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024567
 protein coding gene Chr18:10322598-10428187 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022007
 protein coding gene Chr18:9220366-9314138 (+)
CAST/EiJ MGP_CASTEiJ_G0023366
 protein coding gene Chr18:9706489-9806085 (+)
CBA/J MGP_CBAJ_G0023861
 protein coding gene Chr18:10470704-10581444 (+)
DBA/2J MGP_DBA2J_G0023990
 protein coding gene Chr18:9488411-9582809 (+)
FVB/NJ MGP_FVBNJ_G0023955
 protein coding gene Chr18:9361265-9459999 (+)
LP/J MGP_LPJ_G0024073
 protein coding gene Chr18:9924384-10019238 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023984
 protein coding gene Chr18:10623667-10728656 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024613
 protein coding gene Chr18:9707855-9813865 (+)
PWK/PhJ MGP_PWKPhJ_G0023112
 protein coding gene Chr18:9557778-9655917 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022921
 protein coding gene Chr18:9976146-10072806 (+)
WSB/EiJ MGP_WSBEiJ_G0023432
 protein coding gene Chr18:9707329-9807444 (+)



Homology
more
  • Human Ortholog
    TTC39C, tetratricopeptide repeat domain 39C
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TTC39C, tetratricopeptide repeat domain 39C
  • Synonyms
    C18orf17, HsT2697
  • Links
    NCBI Gene ID: 125488
    neXtProt AC: NX_Q8N584
    UniProt: Q8N584

  • Chr Location
    18q11.2; chr18:23992773-24135610 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    1
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    797
  • Tissues
    14
  • cDNA Data
    47
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024424 Ensembl Gene Model | MGI Sequence Detail 138968 C57BL/6J ±  kb
    transcript ENSMUST00000234966 Ensembl | MGI Sequence Detail 4385 Not Applicable  
    polypeptide ENSMUSP00000157144 Ensembl | MGI Sequence Detail 580 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000030881 tetratricopeptide repeat protein 39C
      (term hierarchy)
    • InterPro Domains
      IPR019412 Inclusion body clearance protein Iml2/Tetratricopeptide repeat protein 39
      IPR011990 Tetratricopeptide-like helical domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 47
      cDNA 47

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1923641
    References
    more
    • Summaries
      All 29
      Developmental Gene Expression 1
      Gene Ontology 1
      Phenotypes 6
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:301695 Hayes CS, et al., Ttc39c is upregulated during skeletal muscle atrophy and modulates ERK1/2 MAP kinase and hedgehog signaling. J Cell Physiol. 2019 Dec;234(12):23807-23824
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory