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Arhgef10l Gene Detail
Summary
  • Symbol
    Arhgef10l
  • Name
    Rho guanine nucleotide exchange factor 10-like
  • Synonyms
    2810441C07Rik, mKIAA1626
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920004
    NCBI Gene: 72754
  • Alliance
    gene page
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:140241796-140393318 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 71.58 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    5278 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920004
 protein coding gene Chr4:140241796-140393323 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029026
 protein coding gene Chr4:143442866-143603838 (-)
A/J MGP_AJ_G0028985
 protein coding gene Chr4:137248494-137407896 (-)
AKR/J MGP_AKRJ_G0028937
 protein coding gene Chr4:141209398-141369060 (-)
BALB/cJ MGP_BALBcJ_G0029009
 protein coding gene Chr4:137943963-138099206 (-)
C3H/HeJ MGP_C3HHeJ_G0028723
 protein coding gene Chr4:141598632-141760351 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029450
 protein coding gene Chr4:148496331-148663082 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026721
 protein coding gene Chr4:130189602-130341494 (-)
CAST/EiJ MGP_CASTEiJ_G0028155
 protein coding gene Chr4:139819627-139971403 (-)
CBA/J MGP_CBAJ_G0028687
 protein coding gene Chr4:152714977-152896168 (-)
DBA/2J MGP_DBA2J_G0028837
 protein coding gene Chr4:137652012-137809724 (-)
FVB/NJ MGP_FVBNJ_G0028804
 protein coding gene Chr4:136742156-136901505 (-)
LP/J MGP_LPJ_G0028936
 protein coding gene Chr4:143494499-143661184 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028830
 protein coding gene Chr4:156655699-156820579 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029488
 protein coding gene Chr4:141730164-141892557 (-)
PWK/PhJ MGP_PWKPhJ_G0027876
 protein coding gene Chr4:134522297-134681399 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027701
 protein coding gene Chr4:137538161-137702916 (-)
WSB/EiJ MGP_WSBEiJ_G0028233
 protein coding gene Chr4:142011911-142181317 (-)



Homology
more
  • Human Ortholog
    ARHGEF10L, Rho guanine nucleotide exchange factor 10 like
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARHGEF10L, Rho guanine nucleotide exchange factor 10 like
  • Synonyms
    GrinchGEF
  • Links
    NCBI Gene ID: 55160
    neXtProt AC: NX_Q9HCE6
    UniProt: Q9HCE6

  • Chr Location
    1p36.13; chr1:17513435-17697875 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human ARHGEF10L associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    716
  • Tissues
    7
  • cDNA Data
    67
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 72754 NCBI Gene Model | MGI Sequence Detail 151523 C57BL/6J ±  kb
transcript NM_001290803 RefSeq | MGI Sequence Detail 4549 C57BL/6  
polypeptide A2AWP8 UniProt | EBI | MGI Sequence Detail 1280 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000004247 Rho guanine nucleotide exchange factor 10-like protein
    (term hierarchy)
  • InterPro Domains
    IPR000219 Dbl homology (DH) domain
    IPR035899 Dbl homology (DH) domain superfamily
    IPR011993 PH-like domain superfamily
    IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily
    IPR039919 Rho guanine nucleotide exchange factor 10/17
    IPR036322 WD40-repeat-containing domain superfamily
    IPR015943 WD40/YVTN repeat-like-containing domain superfamily
  • GlyGen
    A2AWP8 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 69
    cDNA 68
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 38
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 13
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory