Csnk1g2 MGI Mouse Gene Detail - MGI:1920014

Symbol

Csnk1g2
Name

casein kinase 1, gamma 2
Synonyms

2810429I12Rik

Feature Type

protein coding gene
IDs

MGI:1920014
NCBI Gene: 103236
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr10:80458672-80476583 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM
Mapping Data

2 experiments

SNPs within 2kb

340 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920014	protein coding gene	Chr10:80458465-80476605 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017511	protein coding gene	Chr10:81256652-81274650 (+)
A/J	MGP_AJ_G0017489	protein coding gene	Chr10:78411688-78429679 (+)
AKR/J	MGP_AKRJ_G0017450	protein coding gene	Chr10:80561775-80579593 (+)
BALB/cJ	MGP_BALBcJ_G0017451	protein coding gene	Chr10:78626023-78644024 (+)
C3H/HeJ	MGP_C3HHeJ_G0017274	protein coding gene	Chr10:80639974-80658587 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017905	protein coding gene	Chr10:84059188-84078886 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015594	protein coding gene	Chr10:74617229-74635922 (+)
CAST/EiJ	MGP_CASTEiJ_G0016841	protein coding gene	Chr10:80862125-80880411 (+)
CBA/J	MGP_CBAJ_G0017246	protein coding gene	Chr10:87325694-87344188 (+)
DBA/2J	MGP_DBA2J_G0017352	protein coding gene	Chr10:77611621-77629398 (+)
FVB/NJ	MGP_FVBNJ_G0017346	protein coding gene	Chr10:76825316-76843674 (+)
LP/J	MGP_LPJ_G0017423	protein coding gene	Chr10:81723662-81741653 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017372	protein coding gene	Chr10:89251560-89270673 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017946	protein coding gene	Chr10:80543490-80561479 (+)
PWK/PhJ	MGP_PWKPhJ_G0016622	protein coding gene	Chr10:77494517-77511043 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016412	protein coding gene	Chr10:79502434-79522977 (+)
WSB/EiJ	MGP_WSBEiJ_G0016901	protein coding gene	Chr10:80586069-80604047 (+)

Human Ortholog

CSNK1G2, casein kinase 1 gamma 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CSNK1G2, casein kinase 1 gamma 2
Synonyms

CK1g2
Links

HGNC:2455

NCBI Gene ID: 1455

neXtProt AC: NX_P78368

UniProt: P78368
Chr Location

19p13.3; chr19:1941172-1981338 (+) GRCh38

MGI Vertebrate Homology

Csnk1g2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CSNK1G2
Gene Tree

Csnk1g2

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Phenotype Summary

28 phenotypes from 2 alleles in 2 genetic backgrounds
2 phenotypes from multigenic genotypes
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

11
Targeted

2
Genomic Mutations

1 involving Csnk1g2
Incidental Mutations

APF
Find Mice (IMSR)

37 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit accelerated TNF-induced lethality and enhanced cell death in response to various necroptosis-inducing agents. Males exhibit an enhanced necroptosis response and premature reproductive system aging.

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All GO Annotations

34
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

771
Tissues

51
cDNA Data

173
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase csnk1g2

ZFIN csnk1g2a

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All Sequences

72
RefSeq

9
UniProt

4
CCDS

CCDS24029.1, CCDS48638.1

Ensembl

ENSMUSG00000003345 (Evidence)
NCBI Gene

103236

			Length	Strain/Species	Flank
genomic	ENSMUSG00000003345	Ensembl Gene Model \| MGI Sequence Detail	17912	C57BL/6J	± kb
transcript	ENSMUST00000079773	Ensembl \| MGI Sequence Detail	2348	Not Applicable
polypeptide	ENSMUSP00000078706	Ensembl \| MGI Sequence Detail	442	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000005948 casein kinase I isoform gamma-2

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR022247 Casein kinase 1 gamma C-terminal

IPR050235 Casein Kinase 1 Ser/Thr Protein Kinase

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

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All nucleic 174

cDNA 173

Primer pair 1

Microarray probesets 3

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MGI:2143622

Summaries

All 50

Developmental Gene Expression 3

Gene Ontology 8

Phenotypes 19
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Csnk1g2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94584	Chr10:80458045-80458050 (+)	-624 bp
Tssr94585	Chr10:80458511-80458592 (+)	-120 bp
Tssr94586	Chr10:80465480-80465489 (+)	6,813 bp
Tssr94587	Chr10:80465505-80465521 (+)	6,841 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24