Tdp1 MGI Mouse Gene Detail - MGI:1920036 - tyrosyl-DNA phosphodiesterase 1

Symbol

Tdp1
Name

tyrosyl-DNA phosphodiesterase 1
Synonyms

2810481F14Rik, 4921509N21Rik, E430034L06Rik, Gm40556, SCAN1

Feature Type

protein coding gene
IDs

MGI:1920036
NCBI Gene: 104884
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr12:99850776-99921478 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, Syntenic
Mapping Data

3 experiments

SNPs within 2kb

2094 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920036	protein coding gene	Chr12:99850767-99921482 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020013	protein coding gene	Chr12:101336864-101408330 (+)
A/J	MGP_AJ_G0019968	protein coding gene	Chr12:97531300-97601762 (+)
AKR/J	MGP_AKRJ_G0019944	protein coding gene	Chr12:100160646-100233626 (+)
BALB/cJ	MGP_BALBcJ_G0019954	protein coding gene	Chr12:97869649-97940891 (+)
C3H/HeJ	MGP_C3HHeJ_G0019756	protein coding gene	Chr12:100701708-100774486 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020403	protein coding gene	Chr12:104455006-104527468 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018017	protein coding gene	Chr12:94498861-94566897 (+)
CAST/EiJ	MGP_CASTEiJ_G0019302	protein coding gene	Chr12:95799799-95882225 (+)
CBA/J	MGP_CBAJ_G0019728	protein coding gene	Chr12:108331619-108412579 (+)
DBA/2J	MGP_DBA2J_G0019839	protein coding gene	Chr12:96962231-97033320 (+)
FVB/NJ	MGP_FVBNJ_G0019828	protein coding gene	Chr12:95676858-95747313 (+)
LP/J	MGP_LPJ_G0019915	protein coding gene	Chr12:101163056-101236711 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019870	protein coding gene	Chr12:111948800-112021448 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020432	protein coding gene	Chr12:99725463-99799482 (+)
PWK/PhJ	MGP_PWKPhJ_G0019066	protein coding gene	Chr12:91589625-91660407 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018862	protein coding gene	Chr12:93902822-93977899 (+)
WSB/EiJ	MGP_WSBEiJ_G0019356	protein coding gene	Chr12:100581998-100655192 (+)

Human Ortholog

TDP1, tyrosyl-DNA phosphodiesterase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TDP1, tyrosyl-DNA phosphodiesterase 1
Links

HGNC:18884

NCBI Gene ID: 55775

neXtProt AC: NX_Q9NUW8

UniProt: Q9NUW8
Chr Location

14q32.11; chr14:89954939-90044764 (+) GRCh38

MGI Vertebrate Homology

Tdp1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TDP1
Gene Tree

Tdp1

Diseases

1 with Tdp1 mouse models; 1 with human TDP1 associations

Human Disease

Mouse Models

spinocerebellar ataxia with axonal neuropathy 1

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

13 phenotypes from 2 alleles in 4 genetic backgrounds
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

5
Targeted

3
Genomic Mutations

1 involving Tdp1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

53 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit defective single strand DNA repair in neurons, decreased cerebellum size and increased sensitivity to topotecan.

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All GO Annotations

21
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

711
Tissues

4
cDNA Data

10
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tdp1

ZFIN tdp1

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All Sequences

65
RefSeq

14
UniProt

5
CCDS

CCDS26105.2

Ensembl

ENSMUSG00000021177 (Evidence)
NCBI Gene

104884

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021177	Ensembl Gene Model \| MGI Sequence Detail	70703	C57BL/6J	± kb
transcript	ENSMUST00000153627	Ensembl \| MGI Sequence Detail	2036	Not Applicable
polypeptide	ENSMUSP00000118656	Ensembl \| MGI Sequence Detail	609	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000016215 tyrosyl-DNA phosphodiesterase 1

(term hierarchy)
EC

3.1.4.-
InterPro Domains

IPR010347 Tyrosyl-DNA phosphodiesterase I
GlyGen

Q8BJ37 1 site, 1 O-linked glycan (1 site)

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All nucleic 12

cDNA 10

Primer pair 1

Other 1

Microarray probesets 3

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MGI:1918105, MGI:2144890, MGI:2145029, MGI:3041233, MGI:5623441

Summaries

All 48

Developmental Gene Expression 2

Diseases 1

Gene Ontology 7

Phenotypes 23
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tdp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114672	Chr12:99850757-99850790 (+)	-2 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24