About   Help   FAQ
Ubash3b Gene Detail
Summary
  • Symbol
    Ubash3b
  • Name
    ubiquitin associated and SH3 domain containing, B
  • Synonyms
    2810457I06Rik, Sts-1, TULA-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920078
    NCBI Gene: 72828
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:40922056-41069358 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 21.84 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4783 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920078
 protein coding gene Chr9:40922056-41072993 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034674
 protein coding gene Chr9:39262894-39414493 (-)
A/J MGP_AJ_G0034654
 protein coding gene Chr9:38247037-38400848 (-)
AKR/J MGP_AKRJ_G0034580
 protein coding gene Chr9:38966974-39122295 (-)
BALB/cJ MGP_BALBcJ_G0034645
 protein coding gene Chr9:37988852-38141205 (-)
C3H/HeJ MGP_C3HHeJ_G0034356
 protein coding gene Chr9:39491938-39647473 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035168
 protein coding gene Chr9:40506858-40664441 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032081
 protein coding gene Chr9:37872617-38024493 (-)
CAST/EiJ MGP_CASTEiJ_G0033679
 protein coding gene Chr9:39226151-39381717 (-)
CBA/J MGP_CBAJ_G0034329
 protein coding gene Chr9:41893915-42060615 (-)
DBA/2J MGP_DBA2J_G0034488
 protein coding gene Chr9:38179569-38332643 (-)
FVB/NJ MGP_FVBNJ_G0034428
 protein coding gene Chr9:37409175-37559798 (-)
LP/J MGP_LPJ_G0034569
 protein coding gene Chr9:39534077-39690615 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034472
 protein coding gene Chr9:43954984-44029050 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035187
 protein coding gene Chr9:38890786-39048691 (-)
PWK/PhJ MGP_PWKPhJ_G0033384
 protein coding gene Chr9:37996081-38146263 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033220
 protein coding gene Chr9:39123415-39285463 (-)
WSB/EiJ MGP_WSBEiJ_G0033792
 protein coding gene Chr9:38918343-39073415 (-)



Homology
more
  • Human Ortholog
    UBASH3B, ubiquitin associated and SH3 domain containing B
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UBASH3B, ubiquitin associated and SH3 domain containing B
  • Synonyms
    p70, STS-1, STS1, TULA-2, TULA2
  • Links
    NCBI Gene ID: 84959
    neXtProt AC: NX_Q8TF42
    UniProt: Q8TF42

  • Chr Location
    11q24.1; chr11:122655722-122814473 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    5 phenotypes from multigenic genotypes
    21 phenotype references
Mice homozygous for a knock-out allele are viable, fertile, developmentally normal, and do not display any obvious phenotypic abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    847
  • Tissues
    32
  • cDNA Data
    45
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 72828 NCBI Gene Model | MGI Sequence Detail 147303 C57BL/6J ±  kb
transcript NM_176860 RefSeq | MGI Sequence Detail 3826 C57BL/6  
polypeptide Q8BGG7 UniProt | EBI | MGI Sequence Detail 638 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 46
    cDNA 46

    Microarray probesets 4
Other
Accession IDs
less
MGI:2143364
References
more
  • Summaries
    All 53
    Developmental Gene Expression 3
    Gene Ontology 11
    Phenotypes 21
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:353503 Tsai YL, et al., TCR signaling promotes formation of an STS1-Cbl-b complex with pH-sensitive phosphatase activity that suppresses T cell function in acidic environments. Immunity. 2023 Dec 12;56(12):2682-2698.e9
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory