Rtl8c Gene Detail

Summary

• Symbol
  Rtl8c
• Name
  retrotransposon Gag like 8C
• Synonyms
  2900027G03Rik, Cxx1c, Mar8.1, Mart8a

• Feature Type
  protein coding gene
• IDs
  MGI:1920115
  NCBI Gene: 72865
• Alliance
  gene page
• Transcription Start Sites
  4 TSS

Location &
Maps

• Sequence Map
  ChrX:52609999-52610399 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome X, 29.82 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  89 from dbSNP Build 142
• Strain Annotations
  17

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920115	protein coding gene	ChrX:52609889-52611102 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035726	protein coding gene	ChrX:48867649-48868049 (+)
A/J	no annotation
AKR/J	MGP_AKRJ_G0035629	protein coding gene	ChrX:50143460-50143860 (+)
BALB/cJ	MGP_BALBcJ_G0035696	protein coding gene	ChrX:48303719-48304119 (-)
C3H/HeJ	MGP_C3HHeJ_G0035399	protein coding gene	ChrX:49157676-49159239 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036226	protein coding gene	ChrX:50101719-50102119 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033078	protein coding gene	ChrX:46201527-46201898 (-)
CAST/EiJ	MGP_CASTEiJ_G0034693	protein coding gene	ChrX:36514919-36515322 (-)
CBA/J	MGP_CBAJ_G0035374	protein coding gene	ChrX:51486532-51486932 (-)
DBA/2J	MGP_DBA2J_G0035527	protein coding gene	ChrX:48500405-48500805 (+)
FVB/NJ	MGP_FVBNJ_G0035476	protein coding gene	ChrX:48117320-48117720 (+)
LP/J	MGP_LPJ_G0035615	protein coding gene	ChrX:49246050-49246450 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035515	protein coding gene	ChrX:52987327-52987727 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036244	protein coding gene	ChrX:48811986-48812389 (-)
PWK/PhJ	MGP_PWKPhJ_G0034390	protein coding gene	ChrX:36014048-36014451 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0034233	protein coding gene	ChrX:37292432-37292803 (-)
WSB/EiJ	MGP_WSBEiJ_G0034836	protein coding gene	ChrX:48374442-48374845 (-)

Homology

• Human Ortholog
  RTL8A, retrotransposon Gag like 8A

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  RTL8A, retrotransposon Gag like 8A
  
• Synonyms
  CXX1b, FAM127B, MAR8A, SIRH6
• Links
  HGNC:24514

  NCBI Gene ID: 26071

  neXtProt AC: NX_Q9BWD3

  UniProt: Q9BWD3

  
  
• Chr Location
  Xq26.3; chrX:135050932-135052196 (-)  GRCh38

---

• Human Ortholog
  RTL8B, retrotransposon Gag like 8B
  
• Synonyms
  CXX1c, FAM127C, MAR8B, SIRH4
• Links
  HGNC:33156

  NCBI Gene ID: 441518

  neXtProt AC: NX_Q17RB0

  UniProt: Q17RB0

  
  
• Chr Location
  Xq26.3; chrX:135020513-135022542 (-)  GRCh38

---

• Human Ortholog
  RTL8C, retrotransposon Gag like 8C
  
• Synonyms
  CXX1, FAM127A, Mar8, MAR8C, Mart8, MART8C, SIRH5
• Links
  HGNC:2569

  NCBI Gene ID: 8933

  neXtProt AC: NX_A6ZKI3

  UniProt: A6ZKI3

  
  
• Chr Location
  Xq26.3; chrX:135032355-135033546 (+)  GRCh38

---

• MGI Vertebrate Homology
  Rtl8c stringent orthology
  3 human;1 mouse
  
• HCOP
  vertebrate homology predictions: RTL8A, RTL8B, RTL8C
• Gene Tree
  Rtl8c
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype reference
  

• All Mutations and Alleles
  1
• Targeted
  1
• Incidental Mutations
  APF
• Find Mice (IMSR)
  1 strains or lines available

Gene Ontology
(GO)
Classifications

Expression

• Assay Results
  742
• Tissues
  7
• cDNA Data
  42
• Literature Summary
  1

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  30
• RefSeq
  2
• UniProt
  1
• CCDS
  CCDS40975.1

• Ensembl
  ENSMUSG00000051851 (Evidence)
• NCBI Gene
  72865

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000051851	Ensembl Gene Model | MGI Sequence Detail	401	C57BL/6J
transcript	ENSMUST00000063384	Ensembl | MGI Sequence Detail	401	Not Applicable
polypeptide	ENSMUSP00000069901	Ensembl | MGI Sequence Detail	112	Not Applicable

Protein
Information

• UniProt
  1 Sequence
• InterPro Domains
  IPR032549 Domain of unknown function DUF4939
  IPR032567 LDOC1-related

Molecular
Reagents

• All nucleic 42

  cDNA 42

  
  

  Microarray probesets 2

Other
Accession IDs

MGI:5906155

References

• Summaries
  All 20

  Developmental Gene Expression 1

  Phenotypes 1
• Earliest
  J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
• Latest
  J:336757 Mohan HM, et al., RTL8 promotes nuclear localization of UBQLN2 to subnuclear compartments associated with protein quality control. Cell Mol Life Sci. 2022 Mar 5;79(3):176

TSS for Rtl8c:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr160967	ChrX:52609859-52609883 (+)	-128 bp
Tssr160968	ChrX:52609885-52609921 (+)	-96 bp
Tssr160969	ChrX:52609926-52609945 (+)	-63 bp
Tssr160970	ChrX:52609954-52609982 (+)	-31 bp