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Ppp2r2b Gene Detail
Summary
  • Symbol
    Ppp2r2b
  • Name
    protein phosphatase 2, regulatory subunit B, beta
  • Synonyms
    2900026H06Rik, 6330404L05Rik, E130009M08Rik, PP2A-PR55B, PR55-BETA, SCA12
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920180
    NCBI Gene: 72930
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:42777811-43192827 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 22.75 cM, cytoband B3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    11965 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920180
 protein coding gene Chr18:42770497-43216192 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024383
 protein coding gene Chr18:41281689-41718820 (-)
A/J MGP_AJ_G0024350
 protein coding gene Chr18:39855596-40276210 (-)
AKR/J MGP_AKRJ_G0024319
 protein coding gene Chr18:40952052-41382786 (-)
BALB/cJ MGP_BALBcJ_G0024350
 protein coding gene Chr18:39937526-40363440 (-)
C3H/HeJ MGP_C3HHeJ_G0024116
 protein coding gene Chr18:41013820-41439839 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024792
 protein coding gene Chr18:42759481-43205434 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022230
 protein coding gene Chr18:39669523-40081827 (-)
CAST/EiJ MGP_CASTEiJ_G0023591
 protein coding gene Chr18:40968521-41409929 (-)
CBA/J MGP_CBAJ_G0024086
 protein coding gene Chr18:44037027-44453105 (-)
DBA/2J MGP_DBA2J_G0024216
 protein coding gene Chr18:39438738-39859259 (-)
FVB/NJ MGP_FVBNJ_G0024182
 protein coding gene Chr18:39067564-39481280 (-)
LP/J MGP_LPJ_G0024300
 protein coding gene Chr18:41352462-41780835 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024213
 protein coding gene Chr18:45275228-45720706 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024841
 protein coding gene Chr18:40825557-41254926 (-)
PWK/PhJ MGP_PWKPhJ_G0023335
 protein coding gene Chr18:39660894-40081096 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023140
 protein coding gene Chr18:41060088-41491731 (-)
WSB/EiJ MGP_WSBEiJ_G0023654
 protein coding gene Chr18:40742190-41173838 (-)



Homology
more
  • Human Ortholog
    PPP2R2B, protein phosphatase 2 regulatory subunit Bbeta
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPP2R2B, protein phosphatase 2 regulatory subunit Bbeta
  • Synonyms
    B55BETA, PP2AB55BETA, PP2ABBETA, PP2APR55B, PP2APR55BETA, PR2AB55BETA, PR2ABBETA, PR2APR55BETA, PR52B, PR55-BETA, PR55BETA, SCA12
  • Links
    NCBI Gene ID: 5521
    neXtProt AC: NX_Q00005
    UniProt: Q00005

  • Chr Location
    5q32; chr5:146580742-147084784 (-)  GRCh38
Human Diseases
more
  • Diseases
    4 with human PPP2R2B associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    884
  • Tissues
    29
  • cDNA Data
    26
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 72930 NCBI Gene Model | MGI Sequence Detail 415017 C57BL/6J ±  kb
    transcript NM_027531 RefSeq | MGI Sequence Detail 2547 C57BL/6  
    polypeptide Q6ZWR4 UniProt | EBI | MGI Sequence Detail 443 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000013136 serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
      (term hierarchy)
    • InterPro Domains
      IPR000009 Protein phosphatase 2A regulatory subunit PR55
      IPR018067 Protein phosphatase 2A regulatory subunit PR55, conserved site
      IPR001680 WD40 repeat
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    • GlyGen
      Q6ZWR4 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 32
      cDNA 29
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1917986, MGI:2442228
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 7
      Gene Ontology 6
      Phenotypes 14
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory