Ift25 MGI Mouse Gene Detail - MGI:1920188 - intraflagellar transport 25

Symbol

Ift25
Name

intraflagellar transport 25
Synonyms

2900042B11Rik, Hspb11

Feature Type

protein coding gene
IDs

MGI:1920188
NCBI Gene: 72938
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr4:107110889-107137135 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 50.18 cM
Mapping Data

1 experiment

SNPs within 2kb

665 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920188	protein coding gene	Chr4:107110790-107137135 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028536	protein coding gene	Chr4:107933851-107964540 (+)
A/J	MGP_AJ_G0028499	protein coding gene	Chr4:104063379-104090606 (+)
AKR/J	MGP_AKRJ_G0028446	protein coding gene	Chr4:106609823-106643848 (+)
BALB/cJ	MGP_BALBcJ_G0028518	protein coding gene	Chr4:104257405-104284390 (+)
C3H/HeJ	MGP_C3HHeJ_G0028232	protein coding gene	Chr4:107360968-107389267 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028958	protein coding gene	Chr4:111814087-111841436 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026249	protein coding gene	Chr4:99345466-99371956 (+)
CAST/EiJ	MGP_CASTEiJ_G0027668	protein coding gene	Chr4:105176225-105202723 (+)
CBA/J	MGP_CBAJ_G0028201	protein coding gene	Chr4:115437824-115467358 (+)
DBA/2J	MGP_DBA2J_G0028349	protein coding gene	Chr4:103687908-103714229 (+)
FVB/NJ	MGP_FVBNJ_G0028317	protein coding gene	Chr4:102555314-102581525 (+)
LP/J	MGP_LPJ_G0028450	protein coding gene	Chr4:108126931-108153227 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028343	protein coding gene	Chr4:120726301-120755352 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028994	protein coding gene	Chr4:106852423-106879571 (+)
PWK/PhJ	MGP_PWKPhJ_G0027394	protein coding gene	Chr4:101928975-101956874 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027218	protein coding gene	Chr4:104247074-104273896 (+)
WSB/EiJ	MGP_WSBEiJ_G0027749	protein coding gene	Chr4:107032129-107060970 (+)

Human Ortholog

IFT25, intraflagellar transport 25

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IFT25, intraflagellar transport 25
Synonyms

C1orf41, CFAP232, FAP232, HSPB11, HSPCO34, PP25
Links

HGNC:25019

NCBI Gene ID: 51668

neXtProt AC: NX_Q9Y547

UniProt: Q9Y547
Chr Location

1p32.3; chr1:53911576-53946305 (-) GRCh38

MGI Vertebrate Homology

Ift25 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: IFT25
Gene Tree

Ift25

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Phenotype Summary

24 phenotypes from 2 alleles in 2 genetic backgrounds
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (other)

2
Gene trapped

9
Radiation induced

1
Targeted

5
Genomic Mutations

4 involving Ift25
Incidental Mutations

CvDC
Find Mice (IMSR)

10 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice show fetal growth retardation and complete neonatal death due to severe structural heart defects. Omphalocele, polydactyly, left pulmonary isomerism, and skeletal defects such as micrognathia, cleft palate, malaligned sternal vertebrae, and a small rib cage are often observed.

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All GO Annotations

31
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

711
Tissues

4
cDNA Data

17
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ift25

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All Sequences

49
RefSeq

8
UniProt

2
CCDS

CCDS18435.1

Ensembl

ENSMUSG00000063172 (Evidence)
NCBI Gene

72938

			Length	Strain/Species	Flank
genomic	72938	NCBI Gene Model \| MGI Sequence Detail	26247	C57BL/6J	± kb
transcript	NM_028394	RefSeq \| MGI Sequence Detail	640	C57BL/6
polypeptide	Q9D6H2	UniProt \| EBI \| MGI Sequence Detail	143	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000008815 intraflagellar transport protein 25 homolog

(term hierarchy)
InterPro Domains

IPR000421 Coagulation factor 5/8 C-terminal domain

IPR008979 Galactose-binding-like domain superfamily

IPR033558 Intraflagellar transport protein 25

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All nucleic 18

cDNA 17

Primer pair 1

Microarray probesets 4

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MGI:7414012

Summaries

All 50

Developmental Gene Expression 3

Gene Ontology 10

Phenotypes 18
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ift25:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr1253	Chr4:107110425-107110439 (+)	-457 bp
Tssr38232	Chr4:107110452-107110477 (+)	-424 bp
Tssr38233	Chr4:107111084-107111099 (+)	203 bp
Tssr38234	Chr4:107111109-107111115 (+)	223 bp
Tssr38235	Chr4:107111116-107111136 (+)	237 bp
Tssr38236	Chr4:107114315-107114319 (+)	3,428 bp
Tssr38237	Chr4:107119562-107119620 (+)	8,702 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24