Ccnt2 MGI Mouse Gene Detail - MGI:1920199

Symbol

Ccnt2
Name

cyclin T2
Synonyms

2900041I18Rik, CycT2

Feature Type

protein coding gene
IDs

MGI:1920199
NCBI Gene: 72949
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr1:127701901-127732574 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 55.80 cM
Mapping Data

3 experiments

SNPs within 2kb

606 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920199	protein coding gene	Chr1:127701901-127735798 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016422	protein coding gene	Chr1:130994009-131029396 (+)
A/J	MGP_AJ_G0016405	protein coding gene	Chr1:126112275-126146392 (+)
AKR/J	MGP_AKRJ_G0016370	protein coding gene	Chr1:129822848-129858818 (+)
BALB/cJ	MGP_BALBcJ_G0016365	protein coding gene	Chr1:126489561-126524845 (+)
C3H/HeJ	MGP_C3HHeJ_G0016191	protein coding gene	Chr1:130009085-130043029 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016826	protein coding gene	Chr1:135920130-135955814 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014539	protein coding gene	Chr1:119472425-119506738 (+)
CAST/EiJ	MGP_CASTEiJ_G0015772	protein coding gene	Chr1:128969216-129007491 (+)
CBA/J	MGP_CBAJ_G0016164	protein coding gene	Chr1:140499098-140536239 (+)
DBA/2J	MGP_DBA2J_G0016270	protein coding gene	Chr1:125148618-125183235 (+)
FVB/NJ	MGP_FVBNJ_G0016269	protein coding gene	Chr1:123866330-123900781 (+)
LP/J	MGP_LPJ_G0016341	protein coding gene	Chr1:132346333-132381104 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016294	protein coding gene	Chr1:146370896-146405198 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016862	protein coding gene	Chr1:129616532-129650571 (+)
PWK/PhJ	MGP_PWKPhJ_G0015558	protein coding gene	Chr1:124122837-124158274 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015346	protein coding gene	Chr1:128565589-128601837 (+)
WSB/EiJ	MGP_WSBEiJ_G0015834	protein coding gene	Chr1:129563370-129605172 (+)

Human Ortholog

CCNT2, cyclin T2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CCNT2, cyclin T2
Synonyms

CYCT2
Links

HGNC:1600

NCBI Gene ID: 905

neXtProt AC: NX_O60583

UniProt: O60583
Chr Location

2q21.3; chr2:134918235-134959342 (+) GRCh38

MGI Vertebrate Homology

Ccnt2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CCNT2
Gene Tree

Ccnt2

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Phenotype Summary

9 phenotypes from 2 alleles in 2 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

78
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

71
Radiation induced

1
Targeted

3
Genomic Mutations

3 involving Ccnt2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

51 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trap allele die prior to the 4-cell stage.

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All GO Annotations

42
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

796
Tissues

58
cDNA Data

18
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CCNT2

Xenbase ccnt2

ZFIN ccnt2a, ccnt2b

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All Sequences

57
RefSeq

2
UniProt

4
CCDS

CCDS15248.1

Ensembl

ENSMUSG00000026349 (Evidence)
NCBI Gene

72949

			Length	Strain/Species	Flank
genomic	72949	NCBI Gene Model \| MGI Sequence Detail	30674	C57BL/6J	± kb
transcript	NM_028399	RefSeq \| MGI Sequence Detail	3514	Not Specified
polypeptide	Q7TQK0	UniProt \| EBI \| MGI Sequence Detail	723	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000005140 cyclin-T2

(term hierarchy)
InterPro Domains

IPR043198 Cyclin/Cyclin-like subunit Ssn8

IPR013763 Cyclin-like domain

IPR036915 Cyclin-like superfamily

IPR006671 Cyclin, N-terminal

IPR047321 Cyclin-T2, first cyclin box

IPR047322 Cyclin-T2, second cyclin box
GlyGen

Q7TQK0 1 site, 1 O-linked glycan (1 site)

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All nucleic 19

cDNA 18

Primer pair 1

Microarray probesets 10

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MGI:2148067

Summaries

All 54

Developmental Gene Expression 4

Gene Ontology 11

Phenotypes 17
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ccnt2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8489	Chr1:127701920-127701975 (+)	47 bp
Tssr8490	Chr1:127701978-127702009 (+)	93 bp
Tssr8491	Chr1:127711321-127711331 (+)	9,425 bp
Tssr8492	Chr1:127721216-127721218 (+)	19,316 bp
Tssr8493	Chr1:127725259-127725264 (+)	23,361 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24