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Lonrf2 Gene Detail
Summary
  • Symbol
    Lonrf2
  • Name
    LON peptidase N-terminal domain and ring finger 2
  • Synonyms
    2900060P06Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920209
    NCBI Gene: 381338
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:38832750-38875768 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 17.17 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1537 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920209
 protein coding gene Chr1:38832726-38875792 (-)
129S1/SvImJ MGP_129S1SvImJ_G0015951
 protein coding gene Chr1:37474076-37527608 (-)
A/J MGP_AJ_G0015935
 protein coding gene Chr1:36456980-36499058 (-)
AKR/J MGP_AKRJ_G0015890
 protein coding gene Chr1:36951198-36991414 (-)
BALB/cJ MGP_BALBcJ_G0015889
 protein coding gene Chr1:36097562-36138999 (-)
C3H/HeJ MGP_C3HHeJ_G0015722
 protein coding gene Chr1:37188157-37229032 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016342
 protein coding gene Chr1:39080977-39123508 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014064
 protein coding gene Chr1:33423427-33465951 (-)
CAST/EiJ MGP_CASTEiJ_G0015303
 protein coding gene Chr1:37066977-37111629 (-)
CBA/J MGP_CBAJ_G0015694
 protein coding gene Chr1:40158577-40205060 (-)
DBA/2J MGP_DBA2J_G0015795
 protein coding gene Chr1:35748260-35788252 (-)
FVB/NJ MGP_FVBNJ_G0015797
 protein coding gene Chr1:35275052-35317826 (-)
LP/J MGP_LPJ_G0015865
 protein coding gene Chr1:37837430-37877815 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015817
 protein coding gene Chr1:42286711-42329449 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016389
 protein coding gene Chr1:37037857-37080784 (-)
PWK/PhJ MGP_PWKPhJ_G0015086
 protein coding gene Chr1:35539220-35582334 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014868
 protein coding gene Chr1:36967958-37016800 (-)
WSB/EiJ MGP_WSBEiJ_G0015365
 protein coding gene Chr1:36996925-37040406 (-)



Homology
more
  • Human Ortholog
    LONRF2, LON peptidase N-terminal domain and ring finger 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LONRF2, LON peptidase N-terminal domain and ring finger 2
  • Synonyms
    RNF192
  • Links
    NCBI Gene ID: 164832
    neXtProt AC: NX_Q1L5Z9
    UniProt: Q1L5Z9

  • Chr Location
    2q11.2; chr2:100271875-100322501 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
Molecular Function

Biological Process

Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    771
  • Tissues
    10
  • cDNA Data
    7
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 381338 NCBI Gene Model | MGI Sequence Detail 43019 C57BL/6J ±  kb
    transcript NM_001029878 RefSeq | MGI Sequence Detail 6884 C57BL/6  
    polypeptide NP_001025049 RefSeq | MGI Sequence Detail 754 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR003111 Lon protease, N-terminal domain
      IPR046336 Lon protease, N-terminal domain superfamily
      IPR015947 PUA-like superfamily
      IPR011990 Tetratricopeptide-like helical domain superfamily
      IPR019734 Tetratricopeptide repeat
      IPR013083 Zinc finger, RING/FYVE/PHD-type
      IPR001841 Zinc finger, RING-type
      IPR017907 Zinc finger, RING-type, conserved site
    • GlyGen
      F6ZE64 2 sites, 2 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 7

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2138355
    References
    more
    • Summaries
      All 27
      Developmental Gene Expression 2
      Phenotypes 7
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory