Slc17a7 MGI Mouse Gene Detail - MGI:1920211 - solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7

Symbol

Slc17a7
Name

solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7
Synonyms

2900052E22Rik, Vglut1

Feature Type

protein coding gene
IDs

MGI:1920211
NCBI Gene: 72961
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr7:44813373-44825566 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 29.16 cM
Mapping Data

2 experiments

SNPs within 2kb

318 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920211	protein coding gene	Chr7:44813345-44825566 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032205	protein coding gene	Chr7:45400777-45412849 (+)
A/J	MGP_AJ_G0032184	protein coding gene	Chr7:44539037-44550959 (+)
AKR/J	MGP_AKRJ_G0032120	protein coding gene	Chr7:45767513-45781432 (+)
BALB/cJ	MGP_BALBcJ_G0032196	protein coding gene	Chr7:44536253-44550096 (+)
C3H/HeJ	MGP_C3HHeJ_G0031912	protein coding gene	Chr7:46262372-46274633 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032688	protein coding gene	Chr7:47670229-47683592 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029702	protein coding gene	Chr7:47100449-47112982 (+)
CAST/EiJ	MGP_CASTEiJ_G0031240	protein coding gene	Chr7:37650566-37666388 (+)
CBA/J	MGP_CBAJ_G0031876	protein coding gene	Chr7:49228888-49243889 (+)
DBA/2J	MGP_DBA2J_G0032034	protein coding gene	Chr7:44210680-44223187 (+)
FVB/NJ	MGP_FVBNJ_G0031985	protein coding gene	Chr7:43985184-43998186 (+)
LP/J	MGP_LPJ_G0032112	protein coding gene	Chr7:46084464-46096622 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032022	protein coding gene	Chr7:47947239-47960626 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032704	protein coding gene	Chr7:44983464-44996760 (+)
PWK/PhJ	MGP_PWKPhJ_G0030963	protein coding gene	Chr7:37574335-37589357 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030800	protein coding gene	Chr7:32996869-33009463 (+)
WSB/EiJ	MGP_WSBEiJ_G0031357	protein coding gene	Chr7:45479585-45491562 (+)

Human Ortholog

SLC17A7, solute carrier family 17 member 7

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC17A7, solute carrier family 17 member 7
Synonyms

BNPI, VGLUT1
Links

HGNC:16704

NCBI Gene ID: 57030

neXtProt AC: NX_Q9P2U7

UniProt: Q9P2U7
Chr Location

19q13.33; chr19:49429401-49442360 (-) GRCh38

MGI Vertebrate Homology

Slc17a7 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SLC17A7
Gene Tree

Slc17a7

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Phenotype Summary

30 phenotypes from 6 alleles in 7 genetic backgrounds
141 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Endonuclease-mediated

5
Targeted

14
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

40 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygous mutant mice are small and fail to thrive by 3-4 weeks of age. Abnormal excitatory post synaptic potential and currents.

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All GO Annotations

63
GO References

26

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

875
Tissues

56
cDNA Data

35
Literature Summary

150

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc17a7

ZFIN slc17a7a

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All Sequences

45
RefSeq

2
UniProt

4
CCDS

CCDS52244.1

Ensembl

ENSMUSG00000070570 (Evidence)
NCBI Gene

72961

			Length	Strain/Species	Flank
genomic	ENSMUSG00000070570	Ensembl Gene Model \| MGI Sequence Detail	12194	C57BL/6J	± kb
transcript	ENSMUST00000209634	Ensembl \| MGI Sequence Detail	1860	Not Applicable
polypeptide	ENSMUSP00000147661	Ensembl \| MGI Sequence Detail	585	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000014963 vesicular glutamate transporter 1

(term hierarchy)
InterPro Domains

IPR011701 Major facilitator superfamily

IPR020846 Major facilitator superfamily domain

IPR050382 Major Facilitator Superfamily Sodium/Anion Cotransporter

IPR036259 MFS transporter superfamily
GlyGen

Q3TXX4 3 sites, 4 N-linked glycans (2 sites), 1 O-linked glycan (1 site)

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All nucleic 43

cDNA 37

Primer pair 4

Other 2

Microarray probesets 4

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MGI:2142059

Summaries

All 347

Developmental Gene Expression 150

Gene Ontology 26

Phenotypes 141
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:359095 Chang Y, et al., Vglut2-based glutamatergic signaling in central noradrenergic neurons is dispensable for normal breathing and chemosensory reflexes. Elife. 2024 Sep 17;12

TSS for Slc17a7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr66483	Chr7:44813339-44813350 (+)	-28 bp
Tssr66484	Chr7:44813363-44813379 (+)	-2 bp
Tssr66485	Chr7:44819242-44819258 (+)	5,877 bp
Tssr66487	Chr7:44824487-44824497 (+)	11,119 bp
Tssr66488	Chr7:44824581-44824587 (+)	11,211 bp
Tssr2246	Chr7:44824617-44824627 (+)	11,249 bp
Tssr66489	Chr7:44824641-44824655 (+)	11,275 bp
Tssr66490	Chr7:44824722-44824732 (+)	11,354 bp
Tssr66491	Chr7:44824741-44824752 (+)	11,374 bp
Tssr66492	Chr7:44824788-44824806 (+)	11,424 bp
Tssr66493	Chr7:44825003-44825039 (+)	11,648 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24