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Tymp Gene Detail
Summary
  • Symbol
    Tymp
  • Name
    thymidine phosphorylase
  • Synonyms
    2900072D10Rik, Ecgf1, gliostatin, PD-ECGF, PDECGF, Pdgfec
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920212
    NCBI Gene: 72962
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:89256134-89261242 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 44.86 cM, cytoband F1
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    141 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920212
 protein coding gene Chr15:89255834-89261282 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022230
 protein coding gene Chr15:90563219-90568275 (-)
A/J MGP_AJ_G0022189
 protein coding gene Chr15:87099154-87104960 (-)
AKR/J MGP_AKRJ_G0022164
 protein coding gene Chr15:89673977-89681374 (-)
BALB/cJ MGP_BALBcJ_G0022195
 protein coding gene Chr15:87203734-87209182 (-)
C3H/HeJ MGP_C3HHeJ_G0021965
 protein coding gene Chr15:89674678-89679776 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022640
 protein coding gene Chr15:93852944-93859898 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020165
 protein coding gene Chr15:83327020-83331953 (-)
CAST/EiJ MGP_CASTEiJ_G0021487
 protein coding gene Chr15:90450071-90456511 (-)
CBA/J MGP_CBAJ_G0021932
 protein coding gene Chr15:97037323-97042519 (-)
DBA/2J MGP_DBA2J_G0022059
 protein coding gene Chr15:86550213-86555289 (-)
FVB/NJ MGP_FVBNJ_G0022038
 protein coding gene Chr15:85614936-85620549 (-)
LP/J MGP_LPJ_G0022130
 protein coding gene Chr15:90720779-90726305 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022058
 protein coding gene Chr15:101434635-101441760 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022655
 protein coding gene Chr15:89712426-89718878 (-)
PWK/PhJ MGP_PWKPhJ_G0021228
 protein coding gene Chr15:86612809-86618244 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021062
 protein coding gene Chr15:89461109-89467649 (-)
WSB/EiJ MGP_WSBEiJ_G0021536
 protein coding gene Chr15:90201436-90207532 (-)



Homology
more
  • Human Ortholog
    TYMP, thymidine phosphorylase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TYMP, thymidine phosphorylase
  • Synonyms
    ECGF, ECGF1, hPD-ECGF, MEDPS1, MNGIE, MTDPS1, PDECGF, TP
  • Links
    NCBI Gene ID: 1890
    neXtProt AC: NX_P19971
    UniProt: P19971

  • Chr Location
    22q13.33; chr22:50525752-50530085 (-)  GRCh38
Human Diseases
more
  • Diseases
    5 with human TYMP associations

Human Disease Mouse Models
      
IDs
IDs
 View 1 model
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotypes from multigenic genotypes
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit reduced thymidine phosphorylase activity and increased thymidine levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    841
  • Tissues
    121
  • cDNA Data
    5
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022615 Ensembl Gene Model | MGI Sequence Detail 5109 C57BL/6J ±  kb
transcript ENSMUST00000023285 Ensembl | MGI Sequence Detail 2037 Not Applicable  
polypeptide ENSMUSP00000023285 Ensembl | MGI Sequence Detail 471 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000016875 thymidine phosphorylase
    (term hierarchy)
  • EC
    2.4.2.4
  • InterPro Domains
    IPR000312 Glycosyl transferase, family 3
    IPR017459 Glycosyl transferase family 3, N-terminal domain
    IPR036320 Glycosyl transferase family 3, N-terminal domain superfamily
    IPR035902 Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain superfamily
    IPR018090 Pyrimidine-nucleoside phosphorylase, bacterial/eukaryotic
    IPR013102 Pyrimidine nucleoside phosphorylase, C-terminal
    IPR036566 Pyrimidine nucleoside phosphorylase-like, C-terminal domain superfamily
    IPR000053 Thymidine/pyrimidine-nucleoside phosphorylase
Molecular
Reagents
less
  • All nucleic 7
    cDNA 6
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-13213, MGI:97529
References
more
  • Summaries
    All 72
    Developmental Gene Expression 2
    Diseases 3
    Gene Ontology 6
    Phenotypes 34
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:335269 Du L, et al., Thymidine Phosphorylase Deficiency or Inhibition Preserves Cardiac Function in Mice With Acute Myocardial Infarction. J Am Heart Assoc. 2023 Apr 4;12(7):e028023
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory