Tmem138 MGI Mouse Gene Detail - MGI:1920232

Symbol

Tmem138
Name

transmembrane protein 138
Synonyms

1700113I01Rik, 2900055D14Rik

Feature Type

protein coding gene
IDs

MGI:1920232
NCBI Gene: 72982
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr19:10547842-10554726 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 6.60 cM, cytoband B
Mapping Data

3 experiments

SNPs within 2kb

254 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920232	protein coding gene	Chr19:10547842-10554765 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024849	protein coding gene	Chr19:7918856-7925740 (-)
A/J	MGP_AJ_G0024817	protein coding gene	Chr19:7378942-7385809 (-)
AKR/J	MGP_AKRJ_G0024792	protein coding gene	Chr19:7671717-7678586 (-)
BALB/cJ	MGP_BALBcJ_G0024817	protein coding gene	Chr19:7423918-7430786 (-)
C3H/HeJ	MGP_C3HHeJ_G0024583	protein coding gene	Chr19:7554417-7561287 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025265	protein coding gene	Chr19:8280081-8286965 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022692	protein coding gene	Chr19:7799182-7806491 (-)
CAST/EiJ	MGP_CASTEiJ_G0024056	protein coding gene	Chr19:7209348-7216340 (-)
CBA/J	MGP_CBAJ_G0024557	protein coding gene	Chr19:8322173-8329046 (-)
DBA/2J	MGP_DBA2J_G0024684	protein coding gene	Chr19:7391071-7397942 (-)
FVB/NJ	MGP_FVBNJ_G0024651	protein coding gene	Chr19:7436805-7442720 (-)
LP/J	MGP_LPJ_G0024771	protein coding gene	Chr19:7883159-7890030 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024678	protein coding gene	Chr19:8227779-8233691 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025313	protein coding gene	Chr19:7690920-7696662 (-)
PWK/PhJ	MGP_PWKPhJ_G0023801	protein coding gene	Chr19:6833702-6840661 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023606	protein coding gene	Chr19:6868541-6876134 (-)
WSB/EiJ	MGP_WSBEiJ_G0024118	protein coding gene	Chr19:7575892-7582749 (-)

Human Ortholog

TMEM138, transmembrane protein 138

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMEM138, transmembrane protein 138
Synonyms

HSPC196
Links

HGNC:26944

NCBI Gene ID: 51524

neXtProt AC: NX_Q9NPI0

UniProt: Q9NPI0
Chr Location

11q12.2; chr11:61361964-61377890 (+) GRCh38

MGI Vertebrate Homology

Tmem138 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TMEM138
Gene Tree

Tmem138

Diseases

1 with human TMEM138 associations

				Human Disease	Mouse Models
				Joubert syndrome 16 IDs Joubert syndrome 16 DOID:0110985 OMIM:614465

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Gene trapped

4
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

6
GO References

4

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

814
Tissues

20
cDNA Data

14
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tmem138

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All Sequences

57
RefSeq

11
UniProt

3
CCDS

CCDS29581.1

Ensembl

ENSMUSG00000024666 (Evidence)
NCBI Gene

72982

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024666	Ensembl Gene Model \| MGI Sequence Detail	6885	C57BL/6J	± kb
transcript	ENSMUST00000236185	Ensembl \| MGI Sequence Detail	1593	Not Applicable
polypeptide	ENSMUSP00000158212	Ensembl \| MGI Sequence Detail	225	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000032245 transmembrane protein 138

(term hierarchy)
InterPro Domains

IPR024133 Transmembrane protein 138
GlyGen

Q9D6G5 1 site

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All nucleic 14

cDNA 14

Microarray probesets 4

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MGI:1923914

Summaries

All 35

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tmem138:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr158197	Chr19:10554731-10554771 (-)	-25 bp
Tssr158196	Chr19:10554462-10554484 (-)	253 bp
Tssr158195	Chr19:10554417-10554459 (-)	288 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24