Srrm3 MGI Mouse Gene Detail - MGI:1920309 - serine/arginine repetitive matrix 3

Symbol

Srrm3
Name

serine/arginine repetitive matrix 3
Synonyms

2900083I11Rik, SRm300-like, Srrm2l

Feature Type

protein coding gene
IDs

MGI:1920309
NCBI Gene: 58212
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr5:135835744-135903626 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 75.42 cM, cytoband G1
Mapping Data

2 experiments

SNPs within 2kb

1872 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920309	protein coding gene	Chr5:135835693-135903627 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030191	protein coding gene	Chr5:140391372-140469662 (+)
A/J	MGP_AJ_G0030159	protein coding gene	Chr5:134362109-134434063 (+)
AKR/J	MGP_AKRJ_G0030092	protein coding gene	Chr5:138711633-138779156 (+)
BALB/cJ	MGP_BALBcJ_G0030169	protein coding gene	Chr5:135714463-135786024 (+)
C3H/HeJ	MGP_C3HHeJ_G0029885	protein coding gene	Chr5:139297455-139374332 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030622	protein coding gene	Chr5:145627538-145702474 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027845	protein coding gene	Chr5:128662480-128717835 (+)
CAST/EiJ	MGP_CASTEiJ_G0029295	protein coding gene	Chr5:138705637-138784747 (+)
CBA/J	MGP_CBAJ_G0029855	protein coding gene	Chr5:151286615-151364072 (+)
DBA/2J	MGP_DBA2J_G0030006	protein coding gene	Chr5:134257111-134327457 (+)
FVB/NJ	MGP_FVBNJ_G0029961	protein coding gene	Chr5:133405020-133476896 (+)
LP/J	MGP_LPJ_G0030095	protein coding gene	Chr5:140827707-140899531 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029993	protein coding gene	Chr5:154300182-154377512 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030662	protein coding gene	Chr5:138501860-138571231 (+)
PWK/PhJ	MGP_PWKPhJ_G0029009	protein coding gene	Chr5:133320191-133390399 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028844	protein coding gene	Chr5:136046350-136116511 (+)
WSB/EiJ	MGP_WSBEiJ_G0029368	protein coding gene	Chr5:139226231-139303945 (+)

Human Ortholog

SRRM3, serine/arginine repetitive matrix 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SRRM3, serine/arginine repetitive matrix 3
Links

HGNC:26729

NCBI Gene ID: 222183

UniProt: A6NNA2
Chr Location

7q11.23; chr7:76201896-76287288 (+) GRCh38

MGI Vertebrate Homology

Srrm3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SRRM3
Gene Tree

Srrm3

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
4 phenotypes from multigenic genotypes
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Gene trapped

8
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit decreased survival and body size, impaired coordination, ataxia, and tremors, Purkinje cell degeneration, and longer persistence of the cerebellum external granule cell layer.

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All GO Annotations

2
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

743
Tissues

24
cDNA Data

10
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase srrm3

ZFIN srrm3

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All Sequences

59
RefSeq

22
UniProt

3
CCDS

CCDS39319.2

Ensembl

ENSMUSG00000039860 (Evidence)
NCBI Gene

58212

			Length	Strain/Species	Flank
genomic	ENSMUSG00000039860	Ensembl Gene Model \| MGI Sequence Detail	67883	C57BL/6J	± kb
transcript	ENSMUST00000144211	Ensembl \| MGI Sequence Detail	3932	Not Applicable
polypeptide	ENSMUSP00000115695	Ensembl \| MGI Sequence Detail	648	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000030759 serine/arginine repetitive matrix protein 3

(term hierarchy)
InterPro Domains

IPR013170 mRNA splicing factor Cwf21 domain

IPR052109 Serine/Arginine Repetitive Matrix Domain-Containing Protein

IPR047489 Serine/arginine repetitive matrix protein 3, cwf21 domain

IPR029360 Serine/arginine repetitive matrix protein, C-terminal

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All nucleic 17

Genomic 2

cDNA 10

Primer pair 4

Other 1

Microarray probesets 3

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MGI:1931023

Summaries

All 30

Developmental Gene Expression 2

Gene Ontology 2

Phenotypes 8
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:305017 Nakano Y, et al., Inhibition of a transcriptional repressor rescues hearing in a splicing factor-deficient mouse. Life Sci Alliance. 2020 Dec;3(12)

TSS for Srrm3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr49195	Chr5:135835713-135835756 (+)	-9 bp
Tssr49196	Chr5:135880274-135880305 (+)	44,546 bp
Tssr49197	Chr5:135891708-135891713 (+)	55,967 bp
Tssr49198	Chr5:135891874-135891886 (+)	56,136 bp
Tssr49199	Chr5:135891896-135891908 (+)	56,158 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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