Pak5 MGI Mouse Gene Detail - MGI:1920334 - p21 (RAC1) activated kinase 5

Symbol

Pak5
Name

p21 (RAC1) activated kinase 5
Synonyms

2900083L08Rik, Pak5, Pak7

Feature Type

protein coding gene
IDs

MGI:1920334
NCBI Gene: 241656
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr2:135923024-136229887 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 67.32 cM
Mapping Data

1 experiment

SNPs within 2kb

8756 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920334	protein coding gene	Chr2:135923008-136229899 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0026557	protein coding gene	Chr2:139843771-140178994 (-)
A/J	MGP_AJ_G0026521	protein coding gene	Chr2:134157835-134475047 (-)
AKR/J	MGP_AKRJ_G0026495	protein coding gene	Chr2:138013047-138338156 (-)
BALB/cJ	MGP_BALBcJ_G0026533	protein coding gene	Chr2:134547521-134857983 (-)
C3H/HeJ	MGP_C3HHeJ_G0026276	protein coding gene	Chr2:138467929-138791550 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0026978	protein coding gene	Chr2:144050184-144381826 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024355	protein coding gene	Chr2:128721522-129025132 (-)
CAST/EiJ	MGP_CASTEiJ_G0025737	protein coding gene	Chr2:138813916-139136385 (-)
CBA/J	MGP_CBAJ_G0026256	protein coding gene	Chr2:149418509-149755060 (-)
DBA/2J	MGP_DBA2J_G0026390	protein coding gene	Chr2:133537257-133841939 (-)
FVB/NJ	MGP_FVBNJ_G0026354	protein coding gene	Chr2:132126507-132434010 (-)
LP/J	MGP_LPJ_G0026494	protein coding gene	Chr2:140013902-140333586 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026374	protein coding gene	Chr2:153223856-153581335 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027033	protein coding gene	Chr2:138025965-138345793 (-)
PWK/PhJ	MGP_PWKPhJ_G0025473	protein coding gene	Chr2:133136689-133444922 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025275	protein coding gene	Chr2:137127939-137435860 (-)
WSB/EiJ	MGP_WSBEiJ_G0025811	protein coding gene	Chr2:138947265-139266500 (-)

Human Ortholog

PAK5, p21 (RAC1) activated kinase 5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PAK5, p21 (RAC1) activated kinase 5
Synonyms

PAK7
Links

HGNC:15916

NCBI Gene ID: 57144

neXtProt AC: NX_Q9P286

UniProt: Q9P286
Chr Location

20p12.2; chr20:9537370-9839076 (-) GRCh38

MGI Vertebrate Homology

Pak5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PAK5
Gene Tree

Pak5

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References

1 with disease annotations

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Phenotype Summary

8 phenotypes from 2 alleles in 3 genetic backgrounds
11 phenotypes from multigenic genotypes
35 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

1
Radiation induced

2
Targeted

2
Genomic Mutations

3 involving Pak5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

38 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice exhibit impaired active avoidance learning but are otherwise normal.

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All GO Annotations

45
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

737
Tissues

18
cDNA Data

29
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pak5

ZFIN pak5

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All Sequences

58
RefSeq

18
UniProt

5
CCDS

CCDS16790.1

Ensembl

ENSMUSG00000039913 (Evidence)
NCBI Gene

241656

			Length	Strain/Species	Flank
genomic	ENSMUSG00000039913	Ensembl Gene Model \| MGI Sequence Detail	306864	C57BL/6J	± kb
transcript	ENSMUST00000035264	Ensembl \| MGI Sequence Detail	4848	Not Applicable
polypeptide	ENSMUSP00000047285	Ensembl \| MGI Sequence Detail	719	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000012245 serine/threonine-protein kinase PAK 5

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR000095 CRIB domain

IPR036936 CRIB domain superfamily

IPR033923 p21 activated kinase binding domain

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR028754 Serine/threonine-protein kinase PAK5, catalytic domain

IPR050285 STE20 Serine/Threonine-Protein Kinase
GlyGen

Q8C015 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)

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All nucleic 30

cDNA 29

Primer pair 1

Microarray probesets 3

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MGI:6436713

Summaries

All 70

Developmental Gene Expression 5

Diseases 1

Gene Ontology 13

Phenotypes 35
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:357470 Hu B, et al., PAK2 is necessary for myelination in the peripheral nervous system. Brain. 2024 May 3;147(5):1809-1821

TSS for Pak5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr26519	Chr2:136229914-136229925 (-)	-33 bp
Tssr26518	Chr2:136229849-136229905 (-)	10 bp
Tssr26517	Chr2:136229724-136229740 (-)	155 bp
Tssr26516	Chr2:136229660-136229718 (-)	198 bp
Tssr26515	Chr2:136229611-136229618 (-)	272 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24