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Dact2 Gene Detail
Summary
  • Symbol
    Dact2
  • Name
    dishevelled-binding antagonist of beta-catenin 2
  • Synonyms
    2900084M21Rik, dapper2, Dpr2, Frd2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920347
    NCBI Gene: 240025
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:14415492-14424595 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 8.95 cM, cytoband A2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    337 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920347
 protein coding gene Chr17:14415314-14424595 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023163
 protein coding gene Chr17:12003465-12012071 (-)
A/J MGP_AJ_G0023129
 protein coding gene Chr17:11834662-11843255 (-)
AKR/J MGP_AKRJ_G0023099
 protein coding gene Chr17:11731260-11739871 (-)
BALB/cJ MGP_BALBcJ_G0023131
 protein coding gene Chr17:11655950-11666440 (-)
C3H/HeJ MGP_C3HHeJ_G0022892
 protein coding gene Chr17:11917164-11926192 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023572
 protein coding gene Chr17:12573559-12586386 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021084
 protein coding gene Chr17:9876289-9885306 (-)
CAST/EiJ MGP_CASTEiJ_G0022407
 protein coding gene Chr17:11840357-11848826 (-)
CBA/J MGP_CBAJ_G0022866
 protein coding gene Chr17:12969321-12978324 (-)
DBA/2J MGP_DBA2J_G0022999
 protein coding gene Chr17:11561774-11570801 (-)
FVB/NJ MGP_FVBNJ_G0022967
 protein coding gene Chr17:11348866-11357623 (-)
LP/J MGP_LPJ_G0023073
 protein coding gene Chr17:11956432-11965484 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022988
 protein coding gene Chr17:12578457-12593345 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023608
 protein coding gene Chr17:11951969-11962477 (-)
PWK/PhJ MGP_PWKPhJ_G0022155
 protein coding gene Chr17:10987168-10996046 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021985
 protein coding gene Chr17:10941323-10949884 (-)
WSB/EiJ MGP_WSBEiJ_G0022468
 protein coding gene Chr17:12269432-12282261 (-)



Homology
more
  • Human Ortholog
    DACT2, dishevelled binding antagonist of beta catenin 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DACT2, dishevelled binding antagonist of beta catenin 2
  • Synonyms
    bA503C24.7, C6orf116, DAPPER2, DPR2
  • Links
    NCBI Gene ID: 168002
    neXtProt AC: NX_Q5SW24
    UniProt: Q5SW24

  • Chr Location
    6q27; chr6:168292830-168319777 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele develop normally but display enhanced keratinocyte migration and accelerated re-epithelialization during cutaneous wound healing.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1031
  • Tissues
    118
  • cDNA Data
    27
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 240025 NCBI Gene Model | MGI Sequence Detail 9104 C57BL/6J ±  kb
    transcript NM_172826 RefSeq | MGI Sequence Detail 2849 C57BL/6  
    polypeptide Q7TN08 UniProt | EBI | MGI Sequence Detail 757 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 27
      Primer pair 3
      Other 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 8
      Gene Ontology 7
      Phenotypes 13
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory