Wdr37 MGI Mouse Gene Detail - MGI:1920393

Symbol

Wdr37
Name

WD repeat domain 37
Synonyms

3110035P10Rik, 4933417A01Rik, mKIAA0982

Feature Type

protein coding gene
IDs

MGI:1920393
NCBI Gene: 207615
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr13:8853004-8921945 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 3.60 cM, cytoband A1
Mapping Data

3 experiments

SNPs within 2kb

1807 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920393	protein coding gene	Chr13:8853002-8922136 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020218	protein coding gene	Chr13:5427813-5496519 (-)
A/J	MGP_AJ_G0020174	protein coding gene	Chr13:5419578-5483918 (-)
AKR/J	MGP_AKRJ_G0020149	protein coding gene	Chr13:5484668-5547897 (-)
BALB/cJ	MGP_BALBcJ_G0020157	protein coding gene	Chr13:5413575-5478764 (-)
C3H/HeJ	MGP_C3HHeJ_G0019961	protein coding gene	Chr13:5595501-5665318 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020604	protein coding gene	Chr13:5715565-5790094 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018213	protein coding gene	Chr13:5374798-5440492 (-)
CAST/EiJ	MGP_CASTEiJ_G0019501	protein coding gene	Chr13:5329814-5393906 (-)
CBA/J	MGP_CBAJ_G0019928	protein coding gene	Chr13:5894058-5963297 (-)
DBA/2J	MGP_DBA2J_G0020045	protein coding gene	Chr13:5257910-5325190 (-)
FVB/NJ	MGP_FVBNJ_G0020030	protein coding gene	Chr13:5113494-5179897 (-)
LP/J	MGP_LPJ_G0020119	protein coding gene	Chr13:5538952-5600938 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020066	protein coding gene	Chr13:6198563-6276831 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020632	protein coding gene	Chr13:5439601-5505240 (-)
PWK/PhJ	MGP_PWKPhJ_G0019262	protein coding gene	Chr13:5271105-5333899 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019069	protein coding gene	Chr13:5475405-5540468 (-)
WSB/EiJ	MGP_WSBEiJ_G0019559	protein coding gene	Chr13:5350055-5413331 (-)

Human Ortholog

WDR37, WD repeat domain 37

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

WDR37, WD repeat domain 37
Synonyms

NOCGUS
Links

HGNC:31406

NCBI Gene ID: 22884

neXtProt AC: NX_Q9Y2I8

UniProt: Q9Y2I8
Chr Location

10p15.3; chr10:1049538-1160991 (+) GRCh38

MGI Vertebrate Homology

Wdr37 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: WDR37
Gene Tree

Wdr37

Diseases

1 with human WDR37 associations

				Human Disease	Mouse Models
				neurooculocardiogenitourinary syndrome IDs neurooculocardiogenitourinary syndrome DOID:0111675 OMIM:618652

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

11 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Endonuclease-mediated

1
Gene trapped

20
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

39 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

7
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

796
Tissues

13
cDNA Data

81
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase wdr37

ZFIN wdr37

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All Sequences

101
RefSeq

16
UniProt

13
CCDS

CCDS26232.1, CCDS49204.1

Ensembl

ENSMUSG00000021147 (Evidence)
NCBI Gene

207615

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021147	Ensembl Gene Model \| MGI Sequence Detail	68942	C57BL/6J	± kb
transcript	ENSMUST00000021572	Ensembl \| MGI Sequence Detail	4526	Not Applicable
polypeptide	ENSMUSP00000021572	Ensembl \| MGI Sequence Detail	496	Not Applicable

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UniProt

13 Sequences
Protein Ontology

PR:000030346 WD repeat-containing protein 37

(term hierarchy)
InterPro Domains

IPR020472 G-protein beta WD-40 repeat

IPR001680 WD40 repeat

IPR019775 WD40 repeat, conserved site

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily
GlyGen

Q8CBE3 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 82

cDNA 82

Microarray probesets 11

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MGI:1918417, MGI:2145258

Summaries

All 39

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Wdr37:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr121345	Chr13:8921787-8921798 (-)	152 bp
Tssr121344	Chr13:8921732-8921785 (-)	186 bp
Tssr121343	Chr13:8921703-8921716 (-)	235 bp
Tssr121342	Chr13:8921035-8921094 (-)	880 bp
Tssr121341	Chr13:8921003-8921010 (-)	938 bp
Tssr121340	Chr13:8908831-8908865 (-)	13,097 bp
Tssr121339	Chr13:8902040-8902066 (-)	19,892 bp
Tssr121338	Chr13:8866031-8866046 (-)	55,906 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24