Arhgap8 MGI Mouse Gene Detail - MGI:1920417 - Rho GTPase activating protein 8

Symbol

Arhgap8
Name

Rho GTPase activating protein 8
Synonyms

3110043J09Rik

Feature Type

protein coding gene
IDs

MGI:1920417
NCBI Gene: 73167
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr15:84604253-84656408 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 39.99 cM
Mapping Data

2 experiments

SNPs within 2kb

1676 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920417	protein coding gene	Chr15:84604214-84657058 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022181	protein coding gene	Chr15:85534609-85579938 (+)
A/J	MGP_AJ_G0022140	protein coding gene	Chr15:82369086-82415514 (+)
AKR/J	MGP_AKRJ_G0022115	protein coding gene	Chr15:84778029-84830794 (+)
BALB/cJ	MGP_BALBcJ_G0022146	protein coding gene	Chr15:82501143-82546776 (+)
C3H/HeJ	MGP_C3HHeJ_G0021916	protein coding gene	Chr15:84741431-84788829 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022591	protein coding gene	Chr15:88781244-88834052 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020116	protein coding gene	Chr15:78722199-78770202 (+)
CAST/EiJ	MGP_CASTEiJ_G0021438	protein coding gene	Chr15:85534300-85582985 (+)
CBA/J	MGP_CBAJ_G0021883	protein coding gene	Chr15:91669788-91723278 (+)
DBA/2J	MGP_DBA2J_G0022010	protein coding gene	Chr15:81842627-81888392 (+)
FVB/NJ	MGP_FVBNJ_G0021989	protein coding gene	Chr15:80899475-80951534 (+)
LP/J	MGP_LPJ_G0022081	protein coding gene	Chr15:85685557-85732610 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022009	protein coding gene	Chr15:96455296-96506935 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022606	protein coding gene	Chr15:84788116-84837515 (+)
PWK/PhJ	MGP_PWKPhJ_G0021179	protein coding gene	Chr15:81849877-81897877 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021013	protein coding gene	Chr15:84503174-84550125 (+)
WSB/EiJ	MGP_WSBEiJ_G0021487	protein coding gene	Chr15:85285557-85334384 (+)

Human Ortholog

ARHGAP8, Rho GTPase activating protein 8

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ARHGAP8, Rho GTPase activating protein 8
Synonyms

BPGAP1, PP610
Links

HGNC:677

NCBI Gene ID: 23779

neXtProt AC: NX_P85298

UniProt: P85298
Chr Location

22q13.31; chr22:44752558-44862788 (+) GRCh38

Human Ortholog

PRR5-ARHGAP8, PRR5-ARHGAP8 readthrough
Links

HGNC:34512

NCBI Gene ID: 553158
Chr Location

22q13.31; chr22:44702204-44862784 (+) GRCh38

MGI Vertebrate Homology

Arhgap8 stringent orthology
2 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ARHGAP8, PRR5-ARHGAP8
Gene Tree

Arhgap8

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References

1 with disease annotations

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
28 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

80
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

73
Radiation induced

2
Targeted

3
Genomic Mutations

3 involving Arhgap8
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

8
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

761
Tissues

12
cDNA Data

11
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ARHGAP8

Xenbase arhgap8

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All Sequences

63
RefSeq

22
UniProt

2
CCDS

CCDS27712.1

Ensembl

ENSMUSG00000078954 (Evidence)
NCBI Gene

73167

			Length	Strain/Species	Flank
genomic	ENSMUSG00000078954	Ensembl Gene Model \| MGI Sequence Detail	52156	C57BL/6J	± kb
transcript	ENSMUST00000006029	Ensembl \| MGI Sequence Detail	1527	Not Applicable
polypeptide	ENSMUSP00000006029	Ensembl \| MGI Sequence Detail	425	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000004240 Rho GTPase-activating protein 8

(term hierarchy)
InterPro Domains

IPR001251 CRAL-TRIO lipid binding domain

IPR036865 CRAL-TRIO lipid binding domain superfamily

IPR000198 Rho GTPase-activating protein domain

IPR008936 Rho GTPase activation protein

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All nucleic 11

cDNA 11

Microarray probesets 5

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MGI:2146007

Summaries

All 52

Developmental Gene Expression 2

Diseases 1

Gene Ontology 4

Phenotypes 28
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Arhgap8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr132474	Chr15:84604254-84604293 (+)	21 bp
Tssr132475	Chr15:84604294-84604305 (+)	47 bp
Tssr132476	Chr15:84649892-84649908 (+)	45,647 bp
Tssr132477	Chr15:84651075-84651083 (+)	46,826 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24