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Pear1 Gene Detail
Summary
  • Symbol
    Pear1
  • Name
    platelet endothelial aggregation receptor 1
  • Synonyms
    3110045G13Rik, Jedi-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920432
    NCBI Gene: 73182
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:87656404-87676262 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 38.50 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    579 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920432
 protein coding gene Chr3:87655197-87676273 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027367
 protein coding gene Chr3:87868581-87950917 (-)
A/J MGP_AJ_G0027331
 protein coding gene Chr3:84888757-84964794 (-)
AKR/J MGP_AKRJ_G0027297
 protein coding gene Chr3:86943072-87025382 (-)
BALB/cJ MGP_BALBcJ_G0027340
 protein coding gene Chr3:84984436-85060958 (-)
C3H/HeJ MGP_C3HHeJ_G0027083
 protein coding gene Chr3:87237619-87316782 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027786
 protein coding gene Chr3:91095120-91177837 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025139
 protein coding gene Chr3:80508575-80586222 (-)
CAST/EiJ MGP_CASTEiJ_G0026530
 protein coding gene Chr3:87455937-87534502 (-)
CBA/J MGP_CBAJ_G0027058
 protein coding gene Chr3:94174161-94263803 (-)
DBA/2J MGP_DBA2J_G0027194
 protein coding gene Chr3:84372085-84449368 (-)
FVB/NJ MGP_FVBNJ_G0027163
 protein coding gene Chr3:82650953-82729735 (-)
LP/J MGP_LPJ_G0027302
 protein coding gene Chr3:88830999-88911492 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027182
 protein coding gene Chr3:100443585-100526740 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027844
 protein coding gene Chr3:86711974-86797655 (-)
PWK/PhJ MGP_PWKPhJ_G0026263
 protein coding gene Chr3:84174553-84197008 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026080
 protein coding gene Chr3:85899858-85928336 (-)
WSB/EiJ MGP_WSBEiJ_G0026609
 protein coding gene Chr3:87078564-87161472 (-)



Homology
more
  • Human Ortholog
    PEAR1, platelet endothelial aggregation receptor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PEAR1, platelet endothelial aggregation receptor 1
  • Synonyms
    JEDI, MEGF12
  • Links
    NCBI Gene ID: 375033
    neXtProt AC: NX_Q5VY43
    UniProt: Q5VY43

  • Chr Location
    1q23.1; chr1:156893698-156916429 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 2 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show no apparent defects in hemostasis or thrombus formation. Although in vitro dextran sulfate-induced platelet aggregation is impaired, platelet aggregation initiated with physiological agonists is normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    7
  • cDNA Data
    11
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 73182 NCBI Gene Model | MGI Sequence Detail 19859 C57BL/6J ±  kb
    transcript NM_001289601 RefSeq | MGI Sequence Detail 4510 C57BL/6  
    polypeptide Q8VIK5 UniProt | EBI | MGI Sequence Detail 1034 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 11
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 6
      Phenotypes 20
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory