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Bmper Gene Detail
Summary
  • Symbol
    Bmper
  • Name
    BMP-binding endothelial regulator
  • Synonyms
    3110056H04Rik, Crim3, crossveinless-2, Cv2, CV-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920480
    NCBI Gene: 73230
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:23134372-23396496 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 9.55 cM, cytoband A4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6690 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920480
 protein coding gene Chr9:23134372-23396511 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034490
 protein coding gene Chr9:20569449-20833381 (+)
A/J MGP_AJ_G0034468
 protein coding gene Chr9:20145790-20408094 (+)
AKR/J MGP_AKRJ_G0034394
 protein coding gene Chr9:20542581-20796628 (+)
BALB/cJ MGP_BALBcJ_G0034459
 protein coding gene Chr9:20020178-20278544 (+)
C3H/HeJ MGP_C3HHeJ_G0034171
 protein coding gene Chr9:20880083-21137581 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034980
 protein coding gene Chr9:21409458-21679304 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031910
 protein coding gene Chr9:19231198-19486161 (+)
CAST/EiJ MGP_CASTEiJ_G0033493
 protein coding gene Chr9:20710961-20972386 (+)
CBA/J MGP_CBAJ_G0034144
 protein coding gene Chr9:22190477-22468479 (+)
DBA/2J MGP_DBA2J_G0034302
 protein coding gene Chr9:20109822-20384934 (+)
FVB/NJ MGP_FVBNJ_G0034245
 protein coding gene Chr9:19659695-19915310 (+)
LP/J MGP_LPJ_G0034388
 protein coding gene Chr9:20755260-21022280 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034289
 protein coding gene Chr9:23728703-24012959 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035000
 protein coding gene Chr9:20511877-20768551 (+)
PWK/PhJ MGP_PWKPhJ_G0033199
 protein coding gene Chr9:20122218-20376098 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033033
 protein coding gene Chr9:20557687-20814835 (+)
WSB/EiJ MGP_WSBEiJ_G0033609
 protein coding gene Chr9:20256709-20517625 (+)



Homology
more
  • Human Ortholog
    BMPER, BMP binding endothelial regulator
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BMPER, BMP binding endothelial regulator
  • Synonyms
    CRIM3, CV-2, CV2
  • Links
    NCBI Gene ID: 168667
    neXtProt AC: NX_Q8N8U9
    UniProt: Q8N8U9

  • Chr Location
    7p14.3; chr7:33904308-34156427 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human BMPER associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    58 phenotypes from 4 alleles in 3 genetic backgrounds
    15 phenotypes from multigenic genotypes
    3 images
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out mutation exhibit neonatal lethality associated with abnormal lung and skeleton development. Mice heterozygous for a null allele exhibit abnromal lung development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    936
  • Tissues
    145
  • cDNA Data
    23
  • Literature Summary
    36
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031963 Ensembl Gene Model | MGI Sequence Detail 262125 C57BL/6J ±  kb
    transcript ENSMUST00000071982 Ensembl | MGI Sequence Detail 3791 Not Applicable  
    polypeptide ENSMUSP00000071872 Ensembl | MGI Sequence Detail 685 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000004775 BMP-binding endothelial regulator protein
      (term hierarchy)
    • InterPro Domains
      IPR052424 Kielin/Chordin-like & BMP-binding Regulator
      IPR050780 Mucin/von Willebrand/Thrombospondin superfamily
      IPR036084 Serine protease inhibitor-like superfamily
      IPR002919 Trypsin Inhibitor-like, cysteine rich domain
      IPR001846 von Willebrand factor, type D domain
      IPR001007 VWFC domain
      IPR014853 VWF/SSPO/Zonadhesin-like, cysteine-rich domain
    • GlyGen
      Q8CJ69 5 sites, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 24
      Primer pair 2
      Other 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 74
      Developmental Gene Expression 36
      Gene Ontology 9
      Phenotypes 20
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:334974 Pankratz F, et al., BMPER Improves Vascular Remodeling and the Contractile Vascular SMC Phenotype. Int J Mol Sci. 2023 Mar 3;24(5)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory