Snorc MGI Mouse Gene Detail - MGI:1920484 - secondary ossification center associated regulator of chondrocyte maturation

Symbol

Snorc
Name

secondary ossification center associated regulator of chondrocyte maturation
Synonyms

3110079O15Rik, Snorc

Feature Type

protein coding gene
IDs

MGI:1920484
NCBI Gene: 73234
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr1:87397993-87403204 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 44.41 cM, cytoband C5
Mapping Data

2 experiments

SNPs within 2kb

210 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920484	protein coding gene	Chr1:87397734-87403204 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016265	protein coding gene	Chr1:88828200-88833412 (+)
A/J	MGP_AJ_G0016246	protein coding gene	Chr1:85502034-85507246 (+)
AKR/J	MGP_AKRJ_G0016207	protein coding gene	Chr1:88022511-88027722 (+)
BALB/cJ	MGP_BALBcJ_G0016203	protein coding gene	Chr1:85619284-85624495 (+)
C3H/HeJ	MGP_C3HHeJ_G0016031	protein coding gene	Chr1:88281621-88286833 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016659	protein coding gene	Chr1:92143268-92148422 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014381	protein coding gene	Chr1:79952746-79957941 (+)
CAST/EiJ	MGP_CASTEiJ_G0015616	protein coding gene	Chr1:87501268-87506504 (+)
CBA/J	MGP_CBAJ_G0016007	protein coding gene	Chr1:95064688-95069898 (+)
DBA/2J	MGP_DBA2J_G0016110	protein coding gene	Chr1:84801511-84806714 (+)
FVB/NJ	MGP_FVBNJ_G0016109	protein coding gene	Chr1:83863452-83868660 (+)
LP/J	MGP_LPJ_G0016181	protein coding gene	Chr1:89891615-89896862 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016135	protein coding gene	Chr1:98344574-98349785 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016702	protein coding gene	Chr1:88133801-88139004 (+)
PWK/PhJ	MGP_PWKPhJ_G0015403	protein coding gene	Chr1:84102755-84108057 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015183	protein coding gene	Chr1:87053221-87058431 (+)
WSB/EiJ	MGP_WSBEiJ_G0015680	protein coding gene	Chr1:87807066-87812275 (+)

Human Ortholog

SNORC, secondary ossification center associated regulator of chondrocyte maturation

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SNORC, secondary ossification center associated regulator of chondrocyte maturation
Synonyms

ASCL830, C2orf82, UNQ830
Links

HGNC:33763

NCBI Gene ID: 389084

neXtProt AC: NX_Q6UX34

UniProt: Q6UX34
Chr Location

2q37.1; chr2:232857270-232878708 (+) GRCh38

MGI Vertebrate Homology

Snorc stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: SNORC
Gene Tree

Snorc

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

1
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Snorc
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Reduced viability of homozygous mutants is seen. Surviving male homozygous mutant mice exhibit decreased mean serum triglyceride levels when compared with controls. Female homozygous mutants exhibit decreased activity levels during the 12-hour habituation period of home-cage activity testing.

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All GO Annotations

8
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

766
Tissues

39
cDNA Data

8
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase snorc

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All Sequences

39
RefSeq

7
UniProt

2
CCDS

CCDS48305.1

Ensembl

ENSMUSG00000026258 (Evidence)
NCBI Gene

73234

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026258	Ensembl Gene Model \| MGI Sequence Detail	5212	C57BL/6J	± kb
transcript	ENSMUST00000027476	Ensembl \| MGI Sequence Detail	478	Not Applicable
polypeptide	ENSMUSP00000027476	Ensembl \| MGI Sequence Detail	121	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000059875 protein SNORC

(term hierarchy)
InterPro Domains

IPR031500 Protein SNORC

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All nucleic 8

cDNA 8

Microarray probesets 2

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MGI:6154699

Summaries

All 35

Developmental Gene Expression 4

Gene Ontology 5

Phenotypes 11
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Snorc:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr7850	Chr1:87397980-87398003 (+)	-1 bp
Tssr7851	Chr1:87398012-87398013 (+)	20 bp
Tssr7852	Chr1:87398015-87398026 (+)	28 bp
Tssr7853	Chr1:87398030-87398052 (+)	48 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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