Cabcoco1 MGI Mouse Gene Detail - MGI:1920537 - ciliary associated calcium binding coiled-coil 1

Symbol

Cabcoco1
Name

ciliary associated calcium binding coiled-coil 1
Synonyms

1700040L02Rik

Feature Type

protein coding gene
IDs

MGI:1920537
NCBI Gene: 73287
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr10:68266783-68377726 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 35.40 cM, cytoband B5.1
Mapping Data

2 experiments

SNPs within 2kb

3066 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920537	protein coding gene	Chr10:68266783-68377751 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017330	protein coding gene	Chr10:68245523-68368330 (-)
A/J	MGP_AJ_G0017307	protein coding gene	Chr10:65949995-66063213 (-)
AKR/J	MGP_AKRJ_G0017268	protein coding gene	Chr10:67746659-67865342 (-)
BALB/cJ	MGP_BALBcJ_G0017267	protein coding gene	Chr10:66151736-66262357 (-)
C3H/HeJ	MGP_C3HHeJ_G0017091	protein coding gene	Chr10:67746535-67862754 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017725	protein coding gene	Chr10:70690719-70816938 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015415	protein coding gene	Chr10:62637100-62737502 (-)
CAST/EiJ	MGP_CASTEiJ_G0016661	protein coding gene	Chr10:67828536-67938071 (-)
CBA/J	MGP_CBAJ_G0017063	protein coding gene	Chr10:73382951-73511300 (-)
DBA/2J	MGP_DBA2J_G0017168	protein coding gene	Chr10:65329168-65437991 (-)
FVB/NJ	MGP_FVBNJ_G0017161	protein coding gene	Chr10:64500501-64604986 (-)
LP/J	MGP_LPJ_G0017241	protein coding gene	Chr10:68657489-68775133 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017189	protein coding gene	Chr10:75571347-75697208 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017764	protein coding gene	Chr10:67638209-67754846 (-)
PWK/PhJ	MGP_PWKPhJ_G0016445	protein coding gene	Chr10:65140432-65251116 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016227	protein coding gene	Chr10:67022183-67134055 (-)
WSB/EiJ	MGP_WSBEiJ_G0016725	protein coding gene	Chr10:67594186-67714876 (-)

Human Ortholog

CABCOCO1, ciliary associated calcium binding coiled-coil 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CABCOCO1, ciliary associated calcium binding coiled-coil 1
Synonyms

ARIEL, C10orf107
Links

HGNC:28678

NCBI Gene ID: 219621

neXtProt AC: NX_Q8IVU9

UniProt: Q8IVU9
Chr Location

10q21.2; chr10:61662929-61766766 (+) GRCh38

MGI Vertebrate Homology

Cabcoco1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CABCOCO1
Gene Tree

Cabcoco1

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Phenotype Summary

11 phenotypes from 2 alleles in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Cabcoco1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit male infertility, oligozoospermia, asthenozoospermia, and defects in sperm flagellum formation.

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All GO Annotations

7
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

715
Tissues

6
cDNA Data

11
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cabcoco1

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All Sequences

34
RefSeq

4
UniProt

2
CCDS

CCDS23905.1

Ensembl

ENSMUSG00000019945 (Evidence)
NCBI Gene

73287

			Length	Strain/Species	Flank
genomic	ENSMUSG00000019945	Ensembl Gene Model \| MGI Sequence Detail	110944	C57BL/6J	± kb
transcript	ENSMUST00000020103	Ensembl \| MGI Sequence Detail	1262	Not Applicable
polypeptide	ENSMUSP00000020103	Ensembl \| MGI Sequence Detail	308	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000059911 ciliary-associated calcium-binding coiled-coil protein 1

(term hierarchy)
InterPro Domains

IPR032727 Flagellar C1a complex subunit C1a-32

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All nucleic 11

cDNA 11

Microarray probesets 3

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MGI:5908145

Summaries

All 34

Developmental Gene Expression 1

Gene Ontology 2

Phenotypes 14
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cabcoco1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr98021	Chr10:68377672-68377738 (-)	21 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24