Ccdc103 MGI Mouse Gene Detail - MGI:1920543 - coiled-coil domain containing 103

Symbol

Ccdc103
Name

coiled-coil domain containing 103
Synonyms

1700039D13Rik

Feature Type

protein coding gene
IDs

MGI:1920543
NCBI Gene: 73293
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr11:102772050-102776042 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 66.48 cM, cytoband D

SNPs within 2kb

210 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920543	protein coding gene	Chr11:102772030-102776042 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019247	protein coding gene	Chr11:105911791-105915791 (+)
A/J	MGP_AJ_G0019215	protein coding gene	Chr11:101425318-101429328 (+)
AKR/J	MGP_AKRJ_G0019184	protein coding gene	Chr11:104557683-104561695 (+)
BALB/cJ	MGP_BALBcJ_G0019189	protein coding gene	Chr11:101901471-101905483 (+)
C3H/HeJ	MGP_C3HHeJ_G0018998	protein coding gene	Chr11:104779259-104783259 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019638	protein coding gene	Chr11:109190205-109194217 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017264	protein coding gene	Chr11:98848252-98852300 (+)
CAST/EiJ	MGP_CASTEiJ_G0018552	protein coding gene	Chr11:105785277-105789256 (+)
CBA/J	MGP_CBAJ_G0018967	protein coding gene	Chr11:113713182-113717192 (+)
DBA/2J	MGP_DBA2J_G0019079	protein coding gene	Chr11:100939146-100943146 (+)
FVB/NJ	MGP_FVBNJ_G0019069	protein coding gene	Chr11:100481737-100485749 (+)
LP/J	MGP_LPJ_G0019148	protein coding gene	Chr11:106428759-106432759 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019100	protein coding gene	Chr11:113163807-113167819 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019676	protein coding gene	Chr11:104939437-104943449 (+)
PWK/PhJ	MGP_PWKPhJ_G0018315	protein coding gene	Chr11:102010488-102014432 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018107	protein coding gene	Chr11:104704334-104708344 (+)
WSB/EiJ	MGP_WSBEiJ_G0018601	protein coding gene	Chr11:104932811-104936828 (+)

Human Ortholog

DNAAF19, dynein axonemal assembly factor 19

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DNAAF19, dynein axonemal assembly factor 19
Synonyms

CCDC103, CILD17, PR46b, SMH
Links

HGNC:32700

NCBI Gene ID: 388389

neXtProt AC: NX_Q8IW40

UniProt: Q8IW40
Chr Location

17q21.31; chr17:44899142-44905390 (+) GRCh38

MGI Vertebrate Homology

Ccdc103 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DNAAF19
Gene Tree

Ccdc103

Diseases

1 with human DNAAF19 associations

				Human Disease	Mouse Models
				primary ciliary dyskinesia 17 IDs primary ciliary dyskinesia 17 DOID:0110621 ICD10CM:Q34.8 OMIM:614679

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

4
Targeted

1
Genomic Mutations

1 involving Ccdc103
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

18
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

13

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dnaaf19

ZFIN dnaaf19

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All Sequences

36
RefSeq

4
UniProt

2
CCDS

CCDS25506.1

Ensembl

ENSMUSG00000020930 (Evidence)
NCBI Gene

73293

			Length	Strain/Species	Flank
genomic	73293	NCBI Gene Model \| MGI Sequence Detail	3993	C57BL/6J	± kb
transcript	NM_001364757	RefSeq \| MGI Sequence Detail	1870	C57BL/6
polypeptide	Q9D9P2	UniProt \| EBI \| MGI Sequence Detail	237	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000032256 coiled-coil domain-containing protein 103

(term hierarchy)
InterPro Domains

IPR042422 Coiled-coil domain-containing protein 103

IPR031733 Dynein attachment factor, N-terminal

IPR025986 RNA-polymerase II-associated protein 3-like, C-terminal domain
GlyGen

Q9D9P2 1 site, 1 N-linked glycan (1 site)

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All nucleic 13

cDNA 13

Microarray probesets 2

Summaries

All 30

Gene Ontology 5

Phenotypes 10
Earliest

J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ccdc103:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105289	Chr11:102772041-102772072 (+)	7 bp
Tssr105290	Chr11:102772090-102772104 (+)	47 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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