About   Help   FAQ
Itpripl1 Gene Detail
Summary
  • Symbol
    Itpripl1
  • Name
    inositol 1,4,5-triphosphate receptor interacting protein-like 1
  • Synonyms
    1700041B20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920588
    NCBI Gene: 73338
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:126980692-126985362 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 61.79 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    61 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920588
 protein coding gene Chr2:126980689-126985377 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026450
 protein coding gene Chr2:130395784-130400452 (-)
A/J MGP_AJ_G0026414
 protein coding gene Chr2:125119339-125124011 (-)
AKR/J MGP_AKRJ_G0026389
 protein coding gene Chr2:128688289-128692976 (-)
BALB/cJ MGP_BALBcJ_G0026426
 protein coding gene Chr2:125393096-125397756 (-)
C3H/HeJ MGP_C3HHeJ_G0026169
 protein coding gene Chr2:129200406-129205054 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026871
 protein coding gene Chr2:134504288-134508966 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024248
 protein coding gene Chr2:119817411-119822061 (-)
CAST/EiJ MGP_CASTEiJ_G0025630
 protein coding gene Chr2:129413262-129417959 (-)
CBA/J MGP_CBAJ_G0026149
 protein coding gene Chr2:139471958-139476640 (-)
DBA/2J MGP_DBA2J_G0026283
 protein coding gene Chr2:124516095-124520756 (-)
FVB/NJ MGP_FVBNJ_G0026247
 protein coding gene Chr2:123178151-123182822 (-)
LP/J MGP_LPJ_G0026388
 protein coding gene Chr2:130648854-130653536 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026267
 protein coding gene Chr2:143521232-143525911 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026926
 protein coding gene Chr2:128716198-128720889 (-)
PWK/PhJ MGP_PWKPhJ_G0025366
 protein coding gene Chr2:124064272-124068924 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025168
 protein coding gene Chr2:127780188-127784846 (-)
WSB/EiJ MGP_WSBEiJ_G0025704
 protein coding gene Chr2:129606025-129610703 (-)



Homology
more
  • Human Ortholog
    ITPRIPL1, ITPRIP like 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ITPRIPL1, ITPRIP like 1
  • Synonyms
    D1B, KIAA1754L
  • Links
    NCBI Gene ID: 150771
    neXtProt AC: NX_Q6GPH6
    UniProt: Q6GPH6

  • Chr Location
    2q11.2; chr2:96325317-96330517 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show impaired sperm motility, an increase in T cell infiltration within the testis and moderate shrinkage in certain tissue regions of the testis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    1
  • GO References
    1
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000074825 Ensembl Gene Model | MGI Sequence Detail 4671 C57BL/6J ±  kb
    transcript ENSMUST00000110386 Ensembl | MGI Sequence Detail 1898 Not Applicable  
    polypeptide ENSMUSP00000106016 Ensembl | MGI Sequence Detail 547 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000009162 inositol 1,4,5-trisphosphate receptor-interacting protein-like 1
      (term hierarchy)
    • InterPro Domains
      IPR026250 Inositol 1,4,5-trisphosphate receptor-interacting protein-like
      IPR024810 MAB21L/Cyclic GMP-AMP synthase-like receptor
      IPR046906 Mab-21-like, HhH/H2TH-like domain
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 2
      cDNA 14

      Microarray probesets 2
    References
    more
    • Summaries
      All 28
      Gene Ontology 1
      Phenotypes 9
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:348064 Deng S, et al., ITPRIPL1 binds CD3epsilon to impede T cell activation and enable tumor immune evasion. Cell. 2024 Apr 25;187(9):2305-2323.e33
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    07/02/2024
    MGI 6.13     		The Jackson Laboratory